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Entry
EC 3.4.21.21                Enzyme                                 

Name
coagulation factor VIIa;
blood-coagulation factor VIIa;
activated blood coagulation factor VII
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Ile bond in factor X to form factor Xa
Comment
Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family)
History
EC 3.4.21.21 created 1978
Orthology
K01320  coagulation factor VII
Genes
HSA: 2155(F7)
PTR: 744785(F7)
PPS: 100987335(F7)
GGO: 101136216(F7)
PON: 100452636(F7)
NLE: 100607316(F7)
MCC: 721933(F7)
MCF: 102121077(F7)
CSAB: 103214833(F7)
RRO: 104659908(F7)
RBB: 108521813(F7)
CJC: 100410381(F7)
SBQ: 101043113(F7)
MMU: 14068(F7)
RNO: 260320(F7)
CGE: 100759052(F7)
NGI: 103746283(F7)
HGL: 101706917(F7)
CCAN: 109686462(F7)
OCU: 100009399(F7)
TUP: 102482034(F7)
CFA: 607661(F7)
AML: 100471728(F7)
UMR: 103657528(F7)
ORO: 101366144(F7)
FCA: 101090581(F7)
PTG: 102950134(F7)
AJU: 106986724(F7)
BTA: 617960(F7)
BOM: 102272114(F7)
BIU: 109567023(F7)
CHX: 102174404(F7)
OAS: 101118369(F7)
SSC: 733661(F7)
CFR: 102519118(F7)
CDK: 105091336(F7)
LVE: 103076497(F7)
OOR: 101277688(F7)
ECB: 100067072(F7)
EPZ: 103549658(F7)
EAI: 106839877(F7)
MYB: 102260786(F7)
MYD: 102765822(F7)
HAI: 109383930(F7)
RSS: 109455203(F7)
PALE: 102884062(F7)
LAV: 100655748(F7)
TMU: 101347612
MDO: 100022420(F7)
SHR: 100921248(F7)
GGA: 395086(F7)
MGP: 100548839(F7)
APLA: 101796107(F7)
ACYG: 106046420
TGU: 100223776(F7)
GFR: 102035674(F7)
FAB: 101814835(F7)
PMAJ: 107211187(F7)
CCAE: 111922719
CCW: 104686114(F7)
FPG: 101911545(F7)
FCH: 102049587(F7)
CLV: 102092108(F7)
EGZ: 104132450(F7)
AAM: 106493960(F7)
ASN: 102375756(F7)
AMJ: 102560637(F7)
PSS: 102463876(F7)
CMY: 102939588(F7)
CPIC: 101936681(F7)
ACS: 107982633
PBI: 103068222
GJA: 107110910
XLA: 444394(f7.S)
XTR: 780280(f7)
NPR: 108791687(F7)
DRE: 100038778(zgc:163025) 114423(f7)
XMA: 102225133
LCF: 108877177
BPEC: 110166513
ELS: 105019751
LCM: 102350380(F7)
CMK: 103183473
 » show all
Taxonomy
Reference
1  [PMID:4510277]
  Authors
Nemerson Y, Esnouf MP.
  Title
Activation of a proteolytic system by a membrane lipoprotein: mechanism of action of tissue factor.
  Journal
Proc Natl Acad Sci U S A 70:310-4 (1973)
DOI:10.1073/pnas.70.2.310
Reference
2  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
Reference
3  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu Rev Biochem 49:765-811 (1980)
DOI:10.1146/annurev.bi.49.070180.004001
Reference
4
  Authors
Broze, G.J., Jr. and Majerus, P.W.
  Title
Human factor VII.
  Journal
Methods Enzymol 80:228-237 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.21
IUBMB Enzyme Nomenclature: 3.4.21.21
ExPASy - ENZYME nomenclature database: 3.4.21.21
BRENDA, the Enzyme Database: 3.4.21.21
CAS: 65312-43-8

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