KEGG   ENZYME: 3.4.21.35Help
Entry
EC 3.4.21.35                Enzyme                                 

Name
tissue kallikrein;
glandular kallikrein;
pancreatic kallikrein;
submandibular kallikrein;
submaxillary kallikrein;
kidney kallikrein;
urinary kallikrein;
kallikrein;
salivary kallikrein;
kininogenin;
kininogenase;
callicrein;
glumorin;
padreatin;
padutin;
kallidinogenase;
bradykininogenase;
depot-padutin;
urokallikrein;
dilminal D;
onokrein P
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of Arg! bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met! or Leu!. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg! bonds [5]
Comment
Formed from tissue prokallikrein by activation with trypsin. In peptidase family S1 (trypsin family). A large number of tissue kallikrein-related sequences have been reported for rats [16] and mice [7], though fewer seem to exist in other mammals. The few that have been isolated and tested on substrates include mouse gamma-renin (EC 3.4.21.54), submandibular proteinase A [2,15], epidermal growth-factor-binding protein, nerve growth factor gamma-subunit, rat tonin [3,4,9], submaxillary proteinases A and B [10], T-kininogenase [18], kallikreins k7 and k8 [17] and human prostate-specific antigen (gamma-seminoprotein, [6])
History
EC 3.4.21.35 created 1965 as EC 3.4.4.21, transferred 1972 to EC 3.4.21.8, part transferred 1981 to EC 3.4.21.35
Orthology
K01325  tissue kallikrein
Genes
HSA: 3816(KLK1) 3817(KLK2)
PTR: 107969791(KLK1) 748637(KLK2)
PPS: 100967412(KLK2) 100995152(KLK1)
GGO: 101144843(KLK1)
PON: 100431610(KLK1) 100432729(KLK2)
MCC: 106994826(KLK1) 719436(KLK2)
MCF: 102135781(KLK1) 102139474(KLK2)
CSAB: 103235100(KLK1) 103235106(KLK2)
RRO: 104667242(KLK1)
RBB: 108532416(KLK1)
CJC: 100402463(KLK1)
SBQ: 101045013(KLK1) 101045648
MMU: 13646(Klk1b22) 13648(Klk1b9) 16612(Klk1) 16613(Klk1b11) 16616(Klk1b21) 16617(Klk1b24) 16618(Klk1b26) 16622(Klk1b5) 16623(Klk1b1) 16624(Klk1b8) 18050(Klk1b3)
RNO: 100361452(Klk1c4) 100911689 103690048 108348116 24523(Klk1) 24594(Klk1b3) 24841(Klk1c2) 292855(Klk1c12) 292858(Klk1c10) 292866(Klk1c8) 292868(Klk1c9) 292872(Klk1c3) 408242(Klk1c6)
CGE: 100754155(Klk1)
NGI: 103743763(Klk1) 103743764
HGL: 101705888 101719001(Klk1)
OCU: 100101620
TUP: 102489025(KLK1)
CFA: 403942(KLK1) 403967(KLK2)
AML: 100476932(KLK1)
FCA: 101090062(KLK1) 101097936
PTG: 102963319(KLK1) 102963589
AJU: 106989422(KLK1) 106989675
BTA: 493738(KLK1)
BOM: 102283027(KLK1)
BIU: 109571921(KLK1)
PHD: 102344140(KLK1)
CHX: 102177186(KLK1)
OAS: 100048991(KLK1)
SSC: 431673(KLK1)
CFR: 102515972(KLK1)
CDK: 105100157
BACU: 103007165(KLK1)
LVE: 103081797(KLK1)
OOR: 101283477(KLK1)
ECB: 100034023(KLK1E2) 100147008(KLK1)
EAI: 106845317 106845494(KLK1)
MYB: 102251175(KLK1)
MYD: 102765308(KLK1)
HAI: 109390988(KLK1)
PALE: 102893946(KLK1) 102898477
TMU: 101344800
AHA: AHA_3330
 » show all
Taxonomy
Reference
1  [PMID:7043199]
  Authors
Fiedler F, Fink E, Tschesche H, Fritz H.
  Title
Porcine glandular kallikreins.
  Journal
Methods Enzymol 80 Pt C:493-532 (1981)
  Sequence
[ssc:431673]
Reference
2  [PMID:6295764]
  Authors
Anundi H, Ronne H, Peterson PA, Rask L.
  Title
Partial amino-acid sequence of the epidermal growth-factor-binding protein.
  Journal
Eur J Biochem 129:365-71 (1982)
DOI:10.1111/j.1432-1033.1982.tb07059.x
Reference
3  [PMID:6295383]
  Authors
Pesquero JL, Boschcov P, Oliveira MC, Paiva AC.
  Title
Effect of substrate size on tonin activity.
  Journal
Biochem Biophys Res Commun 108:1441-6 (1982)
DOI:10.1016/S0006-291X(82)80068-5
Reference
4  [PMID:6097352]
  Authors
Gutkowska J, Corvol P, Figueiredo AF, Inagami T, Bouhnik J, Genest J
  Title
Kinetic studies of rat renin and tonin on purified rat angiotensinogen.
  Journal
Can J Biochem Cell Biol 62:137-42 (1984)
Reference
5  [PMID:3844939]
  Authors
Kato H, Enjyoji K, Miyata T, Hayashi I, Oh-ishi S, Iwanaga S.
  Title
Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: direct evidence for liberation of bradykinin by rat glandular kallikreins.
  Journal
Biochem Biophys Res Commun 127:289-95 (1985)
DOI:10.1016/S0006-291X(85)80157-1
Reference
6  [PMID:3691800]
  Authors
Akiyama K, Nakamura T, Iwanaga S, Hara M.
  Title
The chymotrypsin-like activity of human prostate-specific antigen, gamma-seminoprotein.
  Journal
FEBS Lett 225:168-72 (1987)
DOI:10.1016/0014-5793(87)81151-1
Reference
7  [PMID:3036794]
  Authors
Evans BA, Drinkwater CC, Richards RI.
  Title
Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus.
  Journal
J Biol Chem 262:8027-34 (1987)
  Sequence
[mmu:16623]
Reference
8  [PMID:3643848]
  Authors
Fiedler F.
  Title
Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin.
  Journal
Eur J Biochem 163:303-12 (1987)
DOI:10.1111/j.1432-1033.1987.tb10801.x
Reference
9  [PMID:2821276]
  Authors
Fujinaga M, James MN.
  Title
Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution.
  Journal
J Mol Biol 195:373-96 (1987)
DOI:10.1016/0022-2836(87)90658-9
  Sequence
[rno:24841]
Reference
10 [PMID:3482210]
  Authors
Kato H, Nakanishi E, Enjyoji K, Hayashi I, Oh-ishi S, Iwanaga S
  Title
Characterization of serine proteinases isolated from rat submaxillary gland: with special reference to the degradation of rat kininogens by these enzymes.
  Journal
J Biochem 102:1389-404 (1987)
Reference
11 [PMID:3237072]
  Authors
Bailey GS.
  Title
Rat pancreas kallikrein.
  Journal
Methods Enzymol 163:115-28 (1988)
Reference
12 [PMID:2611215]
  Authors
Blaber M, Isackson PJ, Marsters JC Jr, Burnier JP, Bradshaw RA.
  Title
Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland.
  Journal
Biochemistry 28:7813-9 (1989)
Reference
13 [PMID:3070295]
  Authors
Chao J, Chao L.
  Title
Rat urinary kallikrein.
  Journal
Methods Enzymol 163:128-43 (1988)
Reference
14 [PMID:2975076]
  Authors
Zakrevskaia SF.
  Title
[Effectiveness of outpatient dental care for the schoolchildren of Arkhangelsk]
  Journal
Stomatologiia (Mosk) 67:62-3 (1988)
Reference
15 [PMID:2523317]
  Authors
Bertrand R, Derancourt J, Kassab R.
  Title
Selective cleavage at lysine of the 50 kDa-20 kDa connector loop segment of skeletal myosin S-1 by endoproteinase Arg-C.
  Journal
FEBS Lett 246:171-6 (1989)
DOI:10.1016/0014-5793(89)80277-7
Reference
16 [PMID:2708383]
  Authors
Wines DR, Brady JM, Pritchett DB, Roberts JL, MacDonald RJ.
  Title
Organization and expression of the rat kallikrein gene family.
  Journal
J Biol Chem 264:7653-62 (1989)
  Sequence
[rno:24594 24841]
Reference
17 [PMID:2194829]
  Authors
Elmoujahed A, Gutman N, Brillard M, Gauthier F.
  Title
Substrate specificity of two kallikrein family gene products isolated from the rat submaxillary gland.
  Journal
FEBS Lett 265:137-40 (1990)
DOI:10.1016/0014-5793(90)80903-V
Reference
18 [PMID:2303430]
  Authors
Xiong W, Chen LM, Chao J.
  Title
Purification and characterization of a kallikrein-like T-kininogenase.
  Journal
J Biol Chem 265:2822-7 (1990)
  Sequence
[rno:292858]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.35
IUBMB Enzyme Nomenclature: 3.4.21.35
ExPASy - ENZYME nomenclature database: 3.4.21.35
BRENDA, the Enzyme Database: 3.4.21.35
CAS: 389069-73-2

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