| Entry |
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| Name |
tissue kallikrein;
glandular kallikrein;
pancreatic kallikrein;
submandibular kallikrein;
submaxillary kallikrein;
kidney kallikrein;
urinary kallikrein;
kallikrein;
salivary kallikrein;
kininogenin;
kininogenase;
callicrein;
glumorin;
padreatin;
padutin;
kallidinogenase;
bradykininogenase;
depot-padutin;
urokallikrein;
dilminal D;
onokrein P
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Preferential cleavage of Arg! bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met! or Leu!. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg! bonds [5]
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| Comment |
Formed from tissue prokallikrein by activation with trypsin. In peptidase family S1 (trypsin family). A large number of tissue kallikrein-related sequences have been reported for rats [16] and mice [7], though fewer seem to exist in other mammals. The few that have been isolated and tested on substrates include mouse gamma-renin (EC 3.4.21.54), submandibular proteinase A [2,15], epidermal growth-factor-binding protein, nerve growth factor gamma-subunit, rat tonin [3,4,9], submaxillary proteinases A and B [10], T-kininogenase [18], kallikreins k7 and k8 [17] and human prostate-specific antigen (gamma-seminoprotein, [6])
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| History |
EC 3.4.21.35 created 1965 as EC 3.4.4.21, transferred 1972 to EC 3.4.21.8, part transferred 1981 to EC 3.4.21.35
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Fiedler F, Fink E, Tschesche H, Fritz H. |
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| Title |
Porcine glandular kallikreins. |
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| Journal |
Methods Enzymol 80 Pt C:493-532 (1981) |
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| Sequence |
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| Reference |
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| Authors |
Anundi H, Ronne H, Peterson PA, Rask L. |
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| Title |
Partial amino-acid sequence of the epidermal growth-factor-binding protein. |
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| Journal |
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| Reference |
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| Authors |
Pesquero JL, Boschcov P, Oliveira MC, Paiva AC. |
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| Title |
Effect of substrate size on tonin activity. |
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| Journal |
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| Reference |
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| Authors |
Gutkowska J, Corvol P, Figueiredo AF, Inagami T, Bouhnik J, Genest J |
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| Title |
Kinetic studies of rat renin and tonin on purified rat angiotensinogen. |
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| Journal |
Can J Biochem Cell Biol 62:137-42 (1984) |
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| Reference |
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| Authors |
Kato H, Enjyoji K, Miyata T, Hayashi I, Oh-ishi S, Iwanaga S. |
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| Title |
Demonstration of arginyl-bradykinin moiety in rat HMW kininogen: direct evidence for liberation of bradykinin by rat glandular kallikreins. |
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| Journal |
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| Reference |
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| Authors |
Akiyama K, Nakamura T, Iwanaga S, Hara M. |
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| Title |
The chymotrypsin-like activity of human prostate-specific antigen, gamma-seminoprotein. |
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| Journal |
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| Reference |
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| Authors |
Evans BA, Drinkwater CC, Richards RI. |
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| Title |
Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus. |
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| Journal |
J Biol Chem 262:8027-34 (1987) |
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| Sequence |
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| Reference |
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| Authors |
Fiedler F. |
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| Title |
Effects of secondary interactions on the kinetics of peptide and peptide ester hydrolysis by tissue kallikrein and trypsin. |
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| Journal |
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| Reference |
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| Authors |
Fujinaga M, James MN. |
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| Title |
Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Kato H, Nakanishi E, Enjyoji K, Hayashi I, Oh-ishi S, Iwanaga S |
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| Title |
Characterization of serine proteinases isolated from rat submaxillary gland: with special reference to the degradation of rat kininogens by these enzymes. |
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| Journal |
J Biochem 102:1389-404 (1987) |
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| Reference |
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| Authors |
Bailey GS. |
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| Title |
Rat pancreas kallikrein. |
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| Journal |
Methods Enzymol 163:115-28 (1988) |
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| Reference |
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| Authors |
Blaber M, Isackson PJ, Marsters JC Jr, Burnier JP, Bradshaw RA. |
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| Title |
Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland. |
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| Journal |
Biochemistry 28:7813-9 (1989) |
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| Reference |
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| Authors |
Chao J, Chao L. |
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| Title |
Rat urinary kallikrein. |
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| Journal |
Methods Enzymol 163:128-43 (1988) |
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| Reference |
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| Authors |
Zakrevskaia SF. |
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| Title |
[Effectiveness of outpatient dental care for the schoolchildren of Arkhangelsk] |
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| Journal |
Stomatologiia (Mosk) 67:62-3 (1988) |
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| Reference |
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| Authors |
Bertrand R, Derancourt J, Kassab R. |
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| Title |
Selective cleavage at lysine of the 50 kDa-20 kDa connector loop segment of skeletal myosin S-1 by endoproteinase Arg-C. |
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| Journal |
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| Reference |
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| Authors |
Wines DR, Brady JM, Pritchett DB, Roberts JL, MacDonald RJ. |
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| Title |
Organization and expression of the rat kallikrein gene family. |
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| Journal |
J Biol Chem 264:7653-62 (1989) |
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| Sequence |
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| Reference |
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| Authors |
Elmoujahed A, Gutman N, Brillard M, Gauthier F. |
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| Title |
Substrate specificity of two kallikrein family gene products isolated from the rat submaxillary gland. |
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| Journal |
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| Reference |
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| Authors |
Xiong W, Chen LM, Chao J. |
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| Title |
Purification and characterization of a kallikrein-like T-kininogenase. |
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| Journal |
J Biol Chem 265:2822-7 (1990) |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.35 |
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