KEGG   ENZYME: 3.4.21.37Help
Entry
EC 3.4.21.37                Enzyme                                 

Name
leukocyte elastase;
lysosomal elastase;
neutrophil elastase;
polymorphonuclear leukocyte elastase;
elastase;
elaszym;
serine elastase;
lysosomal elastase;
granulocyte elastase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including elastin. Preferential cleavage Val! > Ala!
Comment
Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11
History
EC 3.4.21.37 created 1981 (EC 3.4.4.7 created 1961, transferred 1972 to EC 3.4.21.11 created 1972, part incorporated 1984)
Orthology
K01327  leukocyte elastase
Genes
HSA: 1991(ELANE)
PPS: 100969272(ELANE) 100970329
GGO: 101136126(ELANE)
PON: 100452808(ELANE)
NLE: 100595921(ELANE)
MCC: 106992354(ELANE)
MCF: 102135637(ELANE)
CSAB: 103233572(ELANE)
RRO: 104671432(ELANE)
RBB: 108537896(ELANE)
CJC: 100389262(ELANE)
SBQ: 101030517(ELANE)
MMU: 50701(Elane)
RNO: 299606(Elane)
CGE: 100752732(Elane)
NGI: 103737354
HGL: 101705441 101715199(Elane)
CCAN: 109693670
TUP: 102488298(ELANE)
CFA: 442980(ELANE)
AML: 105234312
UMR: 103681765(ELANE)
ORO: 101375336
FCA: 100301482
PTG: 102951727(ELANE)
BTA: 100126050(ELANE)
BOM: 102274925(ELANE)
PHD: 102322848(ELANE)
CHX: 102173292(ELANE)
OAS: 101110841(ELANE)
SSC: 100522182(ELANE)
CFR: 102507529(ELANE)
CDK: 105106576(ELANE)
BACU: 103003856(ELANE)
LVE: 103074519(ELANE)
OOR: 101272927(ELANE)
ECB: 111774155(ELANE)
EPZ: 103544822(ELANE)
EAI: 106834239(ELANE)
MYB: 106723590(ELANE)
MYD: 102756029(ELANE)
HAI: 109390590(ELANE)
RSS: 109437057(ELANE)
PALE: 102888696(ELANE)
LAV: 100672001(ELANE)
TMU: 101350466
MDO: 100030465(ELANE)
SHR: 100932763(ELANE)
OAA: 791113
XTR: 448597(prtn3)
 » show all
Taxonomy
Reference
1  [PMID:7043201]
  Authors
Barrett AJ.
  Title
Leukocyte elastase.
  Journal
Methods Enzymol 80 Pt C:581-8 (1981)
Reference
2  [PMID:6380580]
  Authors
Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.
  Title
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
  Journal
Biochemistry 23:2995-3002 (1984)
Reference
3  [PMID:3646070]
  Authors
Stein RL, Strimpler AM, Hori H, Powers JC.
  Title
Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.
  Journal
Biochemistry 26:1301-5 (1987)
Reference
4  [PMID:2655701]
  Authors
Bode W, Meyer E Jr, Powers JC.
  Title
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
  Journal
Biochemistry 28:1951-63 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.37
IUBMB Enzyme Nomenclature: 3.4.21.37
ExPASy - ENZYME nomenclature database: 3.4.21.37
BRENDA, the Enzyme Database: 3.4.21.37
CAS: 9004-06-2

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