KEGG   ENZYME: 3.4.21.39Help
Entry
EC 3.4.21.39                Enzyme                                 

Name
chymase;
mast cell protease I;
skeletal muscle protease;
skin chymotryptic proteinase;
mast cell serine proteinase, chymase;
skeletal muscle (SK) protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Phe! > Tyr! > Trp! > Leu!
Comment
In mast cell granules. In peptidase family S1 (trypsin family)
History
EC 3.4.21.39 created 1981
Orthology
K01329  chymase
Genes
HSA: 1215(CMA1)
PTR: 745533(CMA1)
PPS: 100986161(CMA1)
GGO: 101131787(CMA1)
PON: 100432060(CMA1)
NLE: 100590719(CMA1)
MCC: 716395(CMA1)
MCF: 102128612(CMA1)
CSAB: 103228741(CMA1)
RRO: 104662665(CMA1)
RBB: 108529495(CMA1)
CJC: 100388845(CMA1)
SBQ: 101040749(CMA1)
MMU: 17227(Mcpt4) 17228(Cma1)
RNO: 100360872(Mcpt1l1) 25627(Cma1)
HGL: 101714023 101714600(Cma1)
OCU: 100008644(CMA1) 100352190
TUP: 102470931 102491108(CMA1)
CFA: 490628(CMA1)
AML: 100468421 100470691(CMA1)
PTG: 102957375 102967390(CMA1)
AJU: 106987850 106987876(CMA1)
PHD: 102321330
SSC: 100156469
CDK: 105102447(CMA1)
BACU: 103010490(CMA1)
LVE: 103078045(CMA1)
OOR: 101287693
ECB: 100050866
EPZ: 103561055(CMA1)
EAI: 106848563
MYB: 102252573(CMA1) 102252869
MYD: 102760823(CMA1) 102774377
PALE: 102891376(CMA1)
LAV: 100676374
TMU: 101353027
MDO: 100025555(CMA1)
SRX: 107728555
SGH: 107599477
MZE: 101464713
 » show all
Taxonomy
Reference
1  [PMID:7043202]
  Authors
Woodbury RG, Everitt MT, Neurath H.
  Title
Mast cell proteases.
  Journal
Methods Enzymol 80 Pt C:588-609 (1981)
Reference
2  [PMID:3893542]
  Authors
Powers JC, Tanaka T, Harper JW, Minematsu Y, Barker L, Lincoln D, Crumley KV, Fraki JE, Schechter NM, Lazarus GG, et al.
  Title
Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors.
  Journal
Biochemistry 24:2048-58 (1985)
Reference
3  [PMID:2425663]
  Authors
Johnson LA, Moon KE, Eisenberg M.
  Title
Purification to homogeneity of the human skin chymotryptic proteinase "chymase".
  Journal
Anal Biochem 155:358-64 (1986)
DOI:10.1016/0003-2697(86)90446-X
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.39
IUBMB Enzyme Nomenclature: 3.4.21.39
ExPASy - ENZYME nomenclature database: 3.4.21.39
BRENDA, the Enzyme Database: 3.4.21.39
CAS: 97501-92-3

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