KEGG   ENZYME: 3.4.21.41Help
Entry
EC 3.4.21.41                Enzyme                                 

Name
complement subcomponent C_overbar_1r_;
activated complement C1r;
C_overbar_1r_ esterase;
activated complement C1r
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Lys(or Arg)!Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42)
Comment
Activated from proenzyme C_overbar_1r_ in plasma during activation of the complement system by the "classical" route. In peptidase family S1 (trypsin family)
History
EC 3.4.21.41 created 1981
Orthology
K01330  complement component 1, r subcomponent
Genes
HSA: 715(C1R)
PTR: 466939(C1R)
PPS: 100991297(C1R)
GGO: 101148245(C1R)
PON: 100173855(C1R)
NLE: 100591142(C1R)
MCC: 722133(C1R)
MCF: 101866354(C1R) 102135038
CSAB: 103218858(C1R) 103218859
RRO: 104681686
RBB: 108542014(C1R)
CJC: 100386784(C1R)
SBQ: 101033061(C1R)
MMU: 50909(C1ra) 667277(C1rb)
RNO: 312705(C1r)
CGE: 100768476(C1r)
NGI: 103727485(C1r)
HGL: 101717538(C1r)
CCAN: 109682779(C1r)
OCU: 100342793(C1R)
TUP: 102496021(C1R)
CFA: 477707(C1R)
AML: 100472269(C1R)
UMR: 103656175(C1R)
ORO: 101377329(C1R)
FCA: 101088940 111561323(C1R)
PTG: 102972961(C1R)
AJU: 106965334(C1R)
BTA: 511581(C1R)
PHD: 102326964(C1R)
CHX: 102188569 102188835(C1R)
SSC: 445464(C1R)
CFR: 102514169(C1R)
CDK: 105098187(C1R)
BACU: 103014234(C1R)
LVE: 103085319(C1R)
OOR: 101269650(C1R)
ECB: 100060297(C1R)
EPZ: 103545781 103563701(C1R)
EAI: 106847307(C1R)
MYB: 102255103(C1R)
MYD: 102754399(C1R)
HAI: 109373632(C1R)
RSS: 109459717(C1R)
PALE: 102897527(C1R)
LAV: 100658090(C1R)
TMU: 101359146
MDO: 100016799(C1R)
SHR: 100925028(C1R)
OAA: 100090998(C1R)
GGA: 418295(C1R)
MGP: 100549554(C1R)
CJO: 107318585(C1R)
APLA: 101791982(C1R)
ACYG: 106047869(C1R)
TGU: 100224962(C1R)
GFR: 102043291(C1R)
FAB: 101809091(C1R)
PHI: 102111934(C1R)
PMAJ: 107207095(C1R)
CCAE: 111938131(C1R)
CCW: 104687137(C1R)
FPG: 101920055(C1R)
FCH: 102054607(C1R)
CLV: 102093497(C1R)
EGZ: 104126607(C1R)
AAM: 106497213(C1R)
ASN: 102373027(C1R)
AMJ: 102572656(C1R)
PSS: 102453764(C1R)
CMY: 102947496(C1R)
ACS: 100558220(c1r)
PVT: 110084645(C1R)
PBI: 103064088(C1R)
GJA: 107106283 107111991(C1R)
XLA: 735208
XTR: 100485749 613057(c1r)
NPR: 108784393(C1R)
SRX: 107724791
SANH: 107671893
SGH: 107552796
IPU: 108263468(C1R) 108268478
LCO: 104932556
NCC: 104941465
MZE: 101486209
OLA: 101173495
XMA: 102236483(c1r)
NFU: 107379532
KMR: 108235398
LCF: 108880662
SDU: 111230024
HCQ: 109515279
BPEC: 110163188
MALB: 109966183
ELS: 105019078
SFM: 108924259
LCM: 102354841(C1R)
CMK: 103172446
 » show all
Taxonomy
Reference
1  [PMID:6281620]
  Authors
Sim RB.
  Title
The human complement system serine proteases C1r and C1s and their proenzymes.
  Journal
Methods Enzymol 80 Pt C:26-42 (1981)
Reference
2  [PMID:3021205]
  Authors
Leytus SP, Kurachi K, Sakariassen KS, Davie EW.
  Title
Nucleotide sequence of the cDNA coding for human complement C1r.
  Journal
Biochemistry 25:4855-63 (1986)
  Sequence
[hsa:715]
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.41
IUBMB Enzyme Nomenclature: 3.4.21.41
ExPASy - ENZYME nomenclature database: 3.4.21.41
BRENDA, the Enzyme Database: 3.4.21.41
CAS: 80295-69-8

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