KEGG   ENZYME: 3.4.21.45Help
Entry
EC 3.4.21.45                Enzyme                                 

Name
complement factor I;
complement component C3b inactivator;
C3b inactivator;
C3b/C4b inactivator;
C3bINA;
complement C3b/C4b inactivator;
complement C4b inactivator;
conglutinogen-activating factor C;
complement C3b inactivator;
factor I;
complement C4bi
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage
Comment
Cleavage of complement subcomponent C3b requires its binding to cofactor factor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. In peptidase family S1 (trypsin family)
History
EC 3.4.21.45 created 1981
Orthology
K01333  complement factor I
Genes
HSA: 3426(CFI)
PTR: 471271(CFI)
PPS: 100972456(CFI)
GGO: 101152970(CFI)
PON: 100189676(CFI)
NLE: 100590769(CFI)
MCC: 720962(CFI)
MCF: 101866929(CFI)
CSAB: 103236106(CFI)
RRO: 104682415(CFI)
RBB: 108541018(CFI)
CJC: 100391781(CFI) 100394341
SBQ: 101045793(CFI)
MMU: 12630(Cfi)
RNO: 79126(Cfi)
CGE: 100767614(Cfi)
NGI: 103742424(Cfi)
HGL: 101705881(Cfi)
CCAN: 109678683(Cfi)
OCU: 100338923(CFI)
TUP: 102481776(CFI)
CFA: 478515(CFI)
AML: 100475600(CFI)
UMR: 103661739(CFI)
ORO: 101376260(CFI)
FCA: 101086649(CFI)
PTG: 102962910(CFI)
AJU: 106983652(CFI)
BTA: 513197(CFI)
BOM: 102287323(CFI)
BIU: 109560254(CFI)
PHD: 102328471(CFI)
CHX: 102183858(CFI)
OAS: 101119307(CFI)
SSC: 100516921(CFI)
CFR: 102523268(CFI)
CDK: 105089900(CFI)
BACU: 103002616(CFI)
LVE: 103075383(CFI)
OOR: 101289802(CFI)
ECB: 100072852(CFI)
EPZ: 103544447 103567319(CFI)
EAI: 106829798(CFI)
MYB: 102252498(CFI)
MYD: 102756039(CFI)
HAI: 109379435(CFI)
RSS: 109452735(CFI)
PALE: 102890675(CFI)
LAV: 100669003(CFI)
TMU: 101355196
MDO: 100010034(CFI)
SHR: 100930026(CFI)
OAA: 100074735(CFI)
GGA: 428773(CFI)
MGP: 100543148(CFI)
CJO: 107313597(CFI)
APLA: 101794428(CFI)
ACYG: 106038641(CFI)
TGU: 100220637(CFI)
GFR: 102034612(CFI)
FAB: 101809393(CFI)
PHI: 102111430(CFI)
PMAJ: 107203568(CFI)
CCAE: 111927779(CFI)
CCW: 104697127(CFI)
FPG: 101911338(CFI)
FCH: 102045934(CFI)
CLV: 102092444(CFI)
EGZ: 104135533(CFI)
AAM: 106492118(CFI)
ASN: 102384439(CFI)
AMJ: 102572976(CFI)
PSS: 102454452(CFI)
CMY: 102932412(CFI)
CPIC: 101933482(CFI)
ACS: 100555342(cfi) 100563609
PVT: 110087284(CFI)
GJA: 107118175 107123133(CFI)
XLA: 379108(cfi.S) 399318(cfi.L)
XTR: 613100(cfi)
NPR: 108798100(CFI)
DRE: 557557(cfi)
SANH: 107673159 107702173(cfi)
IPU: 100306949(cfi)
AMEX: 103047746
TRU: 101075279(cfi)
LCO: 104938260(cfi)
MZE: 101470311(cfi)
OLA: 101171529(cfi)
XMA: 102223757(cfi)
PRET: 103480967
NFU: 107396474(cfi)
KMR: 108249806(cfi)
CSEM: 103389508(cfi)
HCQ: 109508328(cfi)
BPEC: 110163439
MALB: 109972927(cfi)
SASA: 106592446(cfi)
ELS: 105009079
SFM: 108936640(cfi)
LCM: 102357588(CFI)
CMK: 103189378(cfi)
 » show all
Taxonomy
Reference
1  [PMID:7391570]
  Authors
Nagasawa S, Ichihara C, Stroud RM.
  Title
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator.
  Journal
J Immunol 125:578-82 (1980)
Reference
2  [PMID:6210825]
  Authors
Crossley LG.
  Title
C3b inactivator and beta 1H.
  Journal
Methods Enzymol 80 Pt C:112-24 (1981)
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.45
IUBMB Enzyme Nomenclature: 3.4.21.45
ExPASy - ENZYME nomenclature database: 3.4.21.45
BRENDA, the Enzyme Database: 3.4.21.45
CAS: 80295-66-5

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