KEGG   ENZYME: 3.4.21.46Help
Entry
EC 3.4.21.46                Enzyme                                 

Name
complement factor D;
C3 proactivator convertase;
properdin factor D esterase;
factor D;
factor D (complement)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor
Comment
A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C_overbar_1s_. In peptidase family S1 (trypsin family)
History
EC 3.4.21.46 created 1981
Orthology
K01334  component factor D
Genes
HSA: 1675(CFD)
PPS: 100968920(CFD)
GGO: 101136498(CFD)
PON: 100936423(CFD)
NLE: 100599422(CFD)
MCC: 721138(CFD)
MCF: 102136571(CFD)
CSAB: 103233571(CFD)
RRO: 104671463(CFD)
RBB: 108537874(CFD)
CJC: 100389630(CFD)
SBQ: 101030841(CFD)
MMU: 11537(Cfd)
RNO: 54249(Cfd)
CGE: 100763302(Cfd)
NGI: 103737401(Cfd)
HGL: 106007830(Cfd)
CCAN: 109693669(Cfd)
TUP: 106734227(CFD)
CFA: 485095(CFD)
AML: 100483447(CFD)
ORO: 101380360(CFD)
FCA: 101093500(CFD)
AJU: 113596379
BTA: 505647(CFD)
BOM: 102275200(CFD)
PHD: 102340302(CFD)
CHX: 102173560(CFD)
OAS: 101115705(CFD)
SSC: 396877(CFD)
CFR: 102507253(CFD)
CDK: 105106574(CFD)
LVE: 103086658(CFD)
OOR: 101272668(CFD)
ECB: 111774154(CFD)
EAI: 106834238(CFD)
MYD: 102756294(CFD)
HAI: 109390585(CFD)
RSS: 109437053(CFD)
PALE: 102897797(CFD)
LAV: 100672291(CFD)
TMU: 101356637
SHR: 100928352
OAA: 791100(CFD)
GGA: 100857593(CFD)
MGP: 100541228(CFD)
CJO: 107325464(CFD)
APLA: 113845674
TGU: 100224290 101233638
SCAN: 103822039
GFR: 102036496(CFD)
FAB: 101807799(CFD)
PHI: 102114080(CFD)
PMAJ: 107215597
CCAE: 111940403
CCW: 104697052(CFD)
FPG: 101921526(CFD)
FCH: 102048162(CFD)
CLV: 106145861(CFD)
NNI: 104016308(CFD)
AAM: 106484250(CFD)
ASN: 102381206
AMJ: 102567707(CFD)
PSS: 112545587
CMY: 102931053(CFD)
CPIC: 101935732(CFD)
PVT: 110072602(CFD)
PBI: 103066225
PMUR: 107282291(CFD)
GJA: 107120759(CFD)
XLA: 494791(cfd.L)
XTR: 394945(cfd)
NPR: 108798700
DRE: 553553(cfd)
SRX: 107733667
SANH: 107666376 107695014
SGH: 107556907 107581203
CCAR: 109071492 109071498
IPU: 100862744
PHYP: 113544922
AMEX: 103044529
TRU: 101070023
TNG: GSTEN00012908G001
LCO: 104926791
NCC: 104963116
MZE: 101478226
OLA: 100049308(olklklp)
XMA: 102225583
PRET: 103458165
NFU: 107373416
KMR: 108250570
CSEM: 103383188
LCF: 108889155
SDU: 111225539
HCQ: 109511554
BPEC: 110155605
MALB: 109962455
SASA: 101448046
OTW: 112265777
SALP: 112075441
ELS: 105015868
SFM: 108919827
 » show all
Taxonomy
Reference
1  [PMID:6918766]
  Authors
Reid KB, Johnson DM, Gagnon J, Phohaska R.
  Title
Preparation of human factor D of the alternative pathway of complement.
  Journal
Methods Enzymol 80 Pt C:134-43 (1981)
Reference
2  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.46
IUBMB Enzyme Nomenclature: 3.4.21.46
ExPASy - ENZYME nomenclature database: 3.4.21.46
BRENDA, the Enzyme Database: 3.4.21.46
CAS: 37213-56-2

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Gene (139)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (106)   
   KEGG MGENES (1)   
   RefGene (31)   
Protein sequence (103)   
   UniProt (8)   
   SWISS-PROT (5)   
   RefSeq(pep) (10)   
   PDBSTR (79)   
   PMD (1)   
DNA sequence (14)   
   RefSeq(nuc) (11)   
   GenBank (2)   
   EMBL (1)   
3D Structure (34)   
   PDB (34)   
All databases (290)   

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