Entry |
|
Name |
complement factor D;
C3 proactivator convertase;
properdin factor D esterase;
factor D;
factor D (complement)
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
 |
Reaction(IUBMB) |
Selective cleavage of Arg!Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor
|
Comment |
A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C_overbar_1s_. In peptidase family S1 (trypsin family)
|
History |
EC 3.4.21.46 created 1981
|
Orthology |
|
Genes |
» show all
 |
Reference |
|
Authors |
Reid KB, Johnson DM, Gagnon J, Phohaska R. |
Title |
Preparation of human factor D of the alternative pathway of complement. |
Journal |
Methods Enzymol 80 Pt C:134-43 (1981) |
Reference |
|
Authors |
Muller-Eberhard HJ. |
Title |
Molecular organization and function of the complement system. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.21.46 |
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