KEGG ENZYME: 3.4.21.46

ENZYME: 3.4.21.46

Entry

EC 3.4.21.46 Enzyme

Name

complement factor D;
C3 proactivator convertase;
properdin factor D esterase;
factor D;
factor D (complement)

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Selective cleavage of Arg!Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor

Comment

A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C_overbar_1s_. In peptidase family S1 (trypsin family)

History

EC 3.4.21.46 created 1981

Orthology

K01334

complement factor D

Genes

HSA:

1675(CFD)

PPS:	100968920(CFD)

GGO:	101136498(CFD)

PON:	100936423(CFD)

NLE:	100599422(CFD)

MCC:	721138(CFD)

MCF:	102136571(CFD)

CSAB:

103233571(CFD)

RRO:	104671463(CFD)

RBB:	108537874(CFD)

CJC:	100389630(CFD)

SBQ:	101030841(CFD)

MMU:	11537(Cfd)

MCAL:

110303909(Cfd)

MPAH:

110326960(Cfd)

RNO:	54249(Cfd)

MUN:	110551364(Cfd)

CGE:	100763302(Cfd)

NGI:	103737401(Cfd)

HGL:	106007830(Cfd)

CCAN:

109693669(Cfd)

TUP:	106734227(CFD)

CFA:	485095(CFD)

VVP:	112935509(CFD)

AML:	100483447(CFD)

UAH:	113242706(CFD)

ORO:	101380360(CFD)

FCA:	101093500(CFD)

PPAD:

109257710(CFD)

AJU:

113596379

BTA:	505647(CFD)

BOM:	102275200(CFD)

BBUB:

102411586(CFD)

CHX:	102173560(CFD)

OAS:	101115705(CFD)

SSC:	396877(CFD)

CFR:	102507253(CFD)

CDK:	105106574(CFD)

LVE:	103086658(CFD)

OOR:	101272668(CFD)

DLE:	111170499(CFD)

PCAD:

102995550(CFD)

ECB:	111774154(CFD)

EAI:	106834238(CFD)

MYD:	102756294(CFD)

MNA:	107538545(CFD)

HAI:	109390585(CFD)

DRO:

112312287

PALE:

102897797(CFD)

RAY:	107500957(CFD)

MJV:	108395527(CFD)

LAV:	100672291(CFD)

TMU:

101356637

SHR:

100928352

PCW:	110196242(CFD)

OAA:	791100(CFD)

GGA:	100857593(CFD)

MGP:	100541228(CFD)

CJO:	107325464(CFD)

NMEL:

110388819(CFD)

APLA:

TGU:

LSR:

SCAN:

GFR:	102036496(CFD)

FAB:	101807799(CFD)

PHI:	102114080(CFD)

PMAJ:

107215597

CCAE:

111940403

CCW:	104697052(CFD)

ETL:	114066373(CFD)

FPG:	101921526(CFD)

FCH:	102048162(CFD)

CLV:	106145861(CFD)

NNI:	104016308(CFD)

AAM:	106484250(CFD)

ASN:

102381206

AMJ:	102567707(CFD)

PSS:

112545587

CMY:	102931053(CFD)

CPIC:

101935732(CFD)

PVT:	110072602(CFD)

PBI:

103066225

PMUR:

107282291(CFD)

TSR:

106542872

PMUA:

114588305(CFD)

GJA:	107120759(CFD)

XLA:	494791(cfd.L)

XTR:	394945(cfd)

NPR:

108798700

DRE:	553553(cfd)

SRX:

107733667

SANH:

107666376 107695014

SGH:	107556907 107581203

CCAR:

IPU:

PHYP:

AMEX:

EEE:

TRU:

TNG:	GSTEN00012908G001

LCO:

NCC:

MZE:

ONL:

OLA:	100049308(olklklp)

XMA:

XCO:

PRET:

CVG:

NFU:

KMR:

ALIM:

AOCE:

CSEM:

POV:

LCF:

SDU:

SLAL:

HCQ:

BPEC:

MALB:

SASA:

OTW:

SALP:

ELS:

SFM:

PKI:

Reference

1 [PMID:6918766]

Authors

Reid KB, Johnson DM, Gagnon J, Phohaska R.

Title

Preparation of human factor D of the alternative pathway of complement.

Journal

Methods Enzymol 80 Pt C:134-43 (1981)

Reference

2 [PMID:3052276]

Authors

Muller-Eberhard HJ.

Title

Molecular organization and function of the complement system.

Journal

Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.46

IUBMB Enzyme Nomenclature:

3.4.21.46

ExPASy - ENZYME nomenclature database:

3.4.21.46

BRENDA, the Enzyme Database:

3.4.21.46

CAS:	37213-56-2

All links

Gene (165)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (131)   
   KEGG MGENES (2)   
   RefGene (31)   
Protein sequence (111)   
   UniProt (8)   
   SWISS-PROT (5)   
   RefSeq(pep) (10)   
   PDBSTR (87)   
   PMD (1)   
DNA sequence (14)   
   RefSeq(nuc) (11)   
   GenBank (2)   
   EMBL (1)   
3D Structure (36)   
   PDB (36)   
All databases (326)   

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