KEGG   ENZYME: 3.4.21.47Help
Entry
EC 3.4.21.47                Enzyme                                 

Name
alternative-complement-pathway C3/C5 convertase;
complement component C3/C5 convertase (alternative);
proenzyme factor B;
properdin factor B;
C3 proactivator;
glycine-rich beta-glycoprotein;
heat-labile factor;
C3 convertase;
C3b,Bb,CVF,Bb,C5 convertase;
(C3b)n,Bb;
complement C 3(C 5) convertase (amplification);
alternative complement pathway C3(C5) convertase;
C5 convertase;
CVF,Bb;
(CVF)-dependent glycine-rich-beta-glucoprotein;
cobra venom factor-dependent C3 convertase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Arg!Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg! bond in complement component C5 alpha-chain to yield C5a and C5b
Comment
A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. Bb is formed by cleavage of proenzyme factor B by factor D. Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. C3b,Bb is stabilized in plasma by factor P. Complement factor B is in peptidase family S1 (trypsin family)
History
EC 3.4.21.47 created 1981
Orthology
K01335  component factor B
Genes
HSA: 629(CFB)
PTR: 494140(CFB)
PPS: 100990821(CFB)
GGO: 101141641(CFB)
PON: 103890868(CFB)
NLE: 100595765(CFB)
MCC: 716809(CFB)
MCF: 102133787(CFB)
CSAB: 108449896(CFB)
RRO: 104678121(CFB)
RBB: 108520262(CFB)
CJC: 100409227(CFB)
SBQ: 101036079(CFB)
MMU: 14962(Cfb)
RNO: 294257(Cfb)
CGE: 100758781(Cfb)
NGI: 108490121(Cfb)
HGL: 101725137(Cfb)
CCAN: 109689576(Cfb)
OCU: 100355944(CFB)
TUP: 102480574(CFB)
CFA: 100688056(CFB)
AML: 100474759(CFB)
UMR: 103682288(CFB)
ORO: 101378817(CFB)
FCA: 101093018(CFB)
PTG: 102969938(CFB)
AJU: 106983483(CFB)
BTA: 514076(CFB)
BOM: 102267775(CFB)
BIU: 109576933(CFB)
PHD: 102338658(CFB)
CHX: 102175816(CFB)
OAS: 101115072(CFB)
SSC: 100124383(CFB)
CFR: 102519366(CFB)
CDK: 105087438(CFB)
BACU: 103017988(CFB)
LVE: 103071310(CFB)
OOR: 101281312(CFB)
ECB: 100051124(CFB)
EPZ: 103563301(CFB)
EAI: 106831003(CFB)
MYB: 102262757(CFB)
MYD: 102766003(CFB)
HAI: 109373064(CFB)
RSS: 109436752(CFB)
PALE: 102877940(CFB)
LAV: 100668025(CFB)
TMU: 101350698
MDO: 107648882(CFB)
PHI: 106628820(CFB)
AMJ: 102574048(CFB) 109280870
CPIC: 101943785(CFB) 101945361
ACS: 100555786 100555981(cfb)
PVT: 110088690(CFB)
GJA: 107105481(CFB)
XLA: 108698939 373577(cfb.S) 397725(cfb.L)
XTR: 100491419(cfb)
NPR: 108786506
DRE: 30604(cfb) 792472(cfbl)
IPU: 100862742
LCO: 104929932
NCC: 104964654
MZE: 101486732
OLA: 100049430(bf/c2)
PRET: 103475468
KMR: 108237014
CSEM: 103395154
LCF: 108893578
SDU: 111234364
HCQ: 109517895
BPEC: 110158573
MALB: 109959265
SFM: 108934440(cfb) 108938433
LCM: 102360252 102360987(CFB)
CIN: 497244(bf-3)
SPU: 373308(bf)
APLC: 110989117
SKO: 100373330
 » show all
Taxonomy
Reference
1  [PMID:7043188]
  Authors
Kerr MA.
  Title
Human factor B.
  Journal
Methods Enzymol 80 Pt C:102-12 (1981)
Reference
2  [PMID:6323161]
  Authors
Morley BJ, Campbell RD.
  Title
Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen.
  Journal
EMBO J 3:153-7 (1984)
  Sequence
[hsa:629]
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.47
IUBMB Enzyme Nomenclature: 3.4.21.47
ExPASy - ENZYME nomenclature database: 3.4.21.47
BRENDA, the Enzyme Database: 3.4.21.47
CAS: 80295-67-6

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