KEGG   ENZYME: 3.4.21.59Help
Entry
EC 3.4.21.59                Enzyme                                 

Name
tryptase;
mast cell tryptase;
mast cell protease II;
skin tryptase;
lung tryptase;
pituitary tryptase;
mast cell neutral proteinase;
mast cell tryptase;
mast cell neutral proteinase;
mast cell serine proteinase II;
mast cell proteinase II;
mast cell serine proteinase tryptase;
rat mast cell protease II;
tryptase M
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Arg!, Lys!, but with more restricted specificity than trypsin
Comment
Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. In peptidase family S1 (trypsin family). Not inhibited by alpha1-proteinase inhibitor or alpha2-macroglobulin
History
EC 3.4.21.59 created 1992
Orthology
K01340  tryptase
Genes
HSA: 23430(TPSD1) 64499(TPSB2) 7177(TPSAB1)
PTR: 100614054 454333(TPSB2) 468084
PPS: 100978423(TPSB2) 100983216 100983474(TPSG1) 100983559
GGO: 101141984 101142734(TPSB2) 101143084
PON: 100294628 100448573(TPSD1)
NLE: 100586612
MCC: 100425930(TPSB2) 699599(tryptase)
MCF: 102139613(TPSB2) 102140229(TPSAB1)
CSAB: 103225829 103225859
RRO: 104681498 104681499
CJC: 100409652
SBQ: 101042059
MMU: 100503895(Tpsab1) 17229(Tpsb2)
RNO: 29268(Tpsb2) 54271(Tpsab1)
CGE: 100762802
NGI: 103752457(Tpsb2)
HGL: 101712997
CCAN: 109690196
TUP: 102471628
CFA: 100049001
AML: 100477216
UMR: 103668756
ORO: 101378934
BTA: 281545(TPSB2) 786948
PHD: 102316497
OAS: 100144429 443433(TPSB2)
SSC: 110255206 397389(MCT7)
BACU: 103014661
ECB: 100033966(RET)
EPZ: 103542236
EAI: 106836196
MYB: 102258623(TPSB2) 102258917(TPSAB1)
RSS: 109460615
PALE: 102890577(TPSB2) 112481574
MDO: 100022090
OAA: 100087741
BBA: Bd1043
BBAC: EP01_15295
 » show all
Taxonomy
Reference
1  [PMID:6358206]
  Authors
Tanaka T, McRae BJ, Cho K, Cook R, Fraki JE, Johnson DA, Powers JC.
  Title
Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.
  Journal
J Biol Chem 258:13552-7 (1983)
Reference
2  [PMID:3890754]
  Authors
Kido H, Fukusen N, Katunuma N.
  Title
Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions.
  Journal
Arch Biochem Biophys 239:436-43 (1985)
DOI:10.1016/0003-9861(85)90709-X
Reference
3  [PMID:3543004]
  Authors
Cromlish JA, Seidah NG, Marcinkiewicz M, Hamelin J, Johnson DA, Chretien M.
  Title
Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.
  Journal
J Biol Chem 262:1363-73 (1987)
  Sequence
[hsa:7177]
Reference
4  [PMID:3140898]
  Authors
Harvima IT, Schechter NM, Harvima RJ, Fraki JE.
  Title
Human skin tryptase: purification, partial characterization and comparison with human lung tryptase.
  Journal
Biochim Biophys Acta 957:71-80 (1988)
DOI:10.1016/0167-4838(88)90158-6
Reference
5  [PMID:2187193]
  Authors
Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH.
  Title
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
  Journal
Proc Natl Acad Sci U S A 87:3811-5 (1990)
DOI:10.1073/pnas.87.10.3811
  Sequence
[hsa:7177 64499]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.59
IUBMB Enzyme Nomenclature: 3.4.21.59
ExPASy - ENZYME nomenclature database: 3.4.21.59
BRENDA, the Enzyme Database: 3.4.21.59
CAS: 97501-93-4

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