KEGG   ENZYME: 3.4.21.6Help
Entry
EC 3.4.21.6                 Enzyme                                 

Name
coagulation factor Xa;
thrombokinase;
prothrombase;
prothrombinase;
activated blood-coagulation factor X;
autoprothrombin C;
thromboplastin;
plasma thromboplastin;
factor Xa;
activated Stuart-Prower factor;
activated factor X
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin
Comment
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
History
EC 3.4.21.6 created 1972, modified 2011
Orthology
K01314  coagulation factor X
Genes
HSA: 2159(F10)
PTR: 107968009(F10)
PPS: 100987663(F10)
GGO: 101135856(F10)
PON: 100453258(F10)
NLE: 100607918(F10)
MCC: 714132(F10)
MCF: 102123736(F10)
CSAB: 103214832(F10)
RRO: 104659907(F10)
RBB: 108521808(F10)
CJC: 100408094(F10)
SBQ: 101048748(F10)
MMU: 14058(F10)
RNO: 29243(F10)
CGE: 100758763(F10)
NGI: 103746284(F10)
HGL: 101706544(F10)
CCAN: 109686463(F10) 109686926
OCU: 100008647(F10)
TUP: 102482452(F10)
CFA: 476993
AML: 100471482(F10)
UMR: 103657616(F10)
ORO: 101366626(F10)
FCA: 101098029(F10)
PTG: 102964764(F10)
AJU: 106986723
BTA: 280787(F10)
BOM: 102273533(F10)
BIU: 109567024(F10)
PHD: 102319830(F10)
CHX: 102174670(F10)
OAS: 101118624(F10)
SSC: 733662(F10)
CFR: 102523467(F10)
CDK: 105091338(F10)
BACU: 103006373
LVE: 103076225(F10)
OOR: 101275181(F10)
ECB: 100067094(F10)
EPZ: 103549669(F10)
EAI: 106839879(F10)
HAI: 109383929(F10)
RSS: 109455202(F10)
PALE: 102897100(F10)
LAV: 100656027(F10)
TMU: 101347861
MDO: 100022394(F10)
SHR: 100916022(F10)
OAA: 790961(F10)
GGA: 395876(F10)
MGP: 100549606(F10)
CJO: 107307824(F10)
APLA: 101795784(F10)
ACYG: 106046423(F10)
TGU: 100218905 100221743(F10)
GFR: 102045057(F10) 106631792
FAB: 101818023(F10) 101819399
PMAJ: 107211181(F10)
CCAE: 111944764
CCW: 104686115(F10)
FPG: 101922977(F10)
FCH: 102052312(F10)
CLV: 102094780(F10) 110360871
EGZ: 104132462(F10)
ASN: 102370854(F10)
AMJ: 102559264(F10)
PSS: 102463618(F10)
CMY: 102933056(F10)
CPIC: 101933935 101936955(F10)
ACS: 100555331(f10)
PVT: 110074104(F10) 110075865
XLA: 398778(f10.L)
XTR: 108644439 548445(f10)
NPR: 108791698(F10)
DRE: 282670(f10)
IPU: 108258588(F10) 108277713
TRU: 101066031 445942(f10)
LCO: 104936794(f10)
NCC: 104953487
OLA: 101163720
KMR: 108228942
CSEM: 103389832
SDU: 111235522
SASA: 100380442(fa9) 106575752
SFM: 108922151
LCM: 102348987(PROC) 102352858
 » show all
Taxonomy
Reference
1  [PMID:1012041]
  Authors
Fujikawa K, Davie EW.
  Title
Bovine factor X (Stuart factor).
  Journal
Methods Enzymol 45:89-95 (1976)
DOI:10.1016/S0076-6879(76)45013-9
Reference
2  [PMID:1012042]
  Authors
Jesty J, Nemerson Y.
  Title
The activation of bovine coagulation factor X.
  Journal
Methods Enzymol 45:95-107 (1976)
DOI:10.1016/S0076-6879(76)45014-0
Reference
3  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
Reference
4  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu Rev Biochem 49:765-811 (1980)
DOI:10.1146/annurev.bi.49.070180.004001
Reference
5  [PMID:6871167]
  Authors
McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B.
  Title
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.
  Journal
Biochemistry 22:2875-84 (1983)
  Sequence
[hsa:2159]
Reference
6  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.6
IUBMB Enzyme Nomenclature: 3.4.21.6
ExPASy - ENZYME nomenclature database: 3.4.21.6
BRENDA, the Enzyme Database: 3.4.21.6
CAS: 9002-05-5

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