KEGG   ENZYME: 3.4.21.61Help
Entry
EC 3.4.21.61                Enzyme                                 

Name
kexin;
yeast KEX2 protease;
proteinase yscF;
prohormone-processing endoprotease;
paired-basic endopeptidase;
yeast cysteine proteinase F (misleading);
paired-basic endopeptidase;
andrenorphin-Gly-generating enzyme;
endoproteinase Kex2p;
gene KEX2 dibasic proteinase;
Kex 2p proteinase;
Kex2 endopeptidase;
Kex2 endoprotease;
Kex2 endoproteinase;
Kex2 protease;
proteinase Kex2p;
Kex2-like precursor protein processing endoprotease;
prohormone-processing KEX2 proteinase;
prohormone-processing proteinase;
proprotein convertase;
protease KEX2;
Kex2 proteinase;
Kex2-like endoproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of -Lys-Arg! and -Arg-Arg! bonds to process yeast alpha-factor pheromone and killer toxin precursors
Comment
A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals.
History
EC 3.4.21.61 created 1989 as EC 3.4.22.23, transferred 1992 to EC 3.4.21.61
Orthology
K01341  kexin
Genes
SCE: YNL238W(KEX2)
AGO: AGOS_ABL203W
ERC: Ecym_6486
KLA: KLLA0_D19811g
KMX: KLMA_50628(KEX1)
LTH: KLTH0H00418g
VPO: Kpol_1015p8
ZRO: ZYRO0F15598g
CGR: CAGL0J07546g
NCS: NCAS_0A00880(NCAS0A00880)
NDI: NDAI_0F03890(NDAI0F03890)
TPF: TPHA_0P01790(TPHA0P01790)
TBL: TBLA_0B00130(TBLA0B00130)
TDL: TDEL_0E00410(TDEL0E00410)
KAF: KAFR_0A08040(KAFR0A08040)
CAL: CAALFM_C108990CA(KEX2)
CAUR: QG37_03795
SLB: AWJ20_2368(KEX2)
NCR: NCU03219
NTE: NEUTE1DRAFT133220(NEUTE1DRAFT_133220)
MGR: MGG_15291
SSCK: SPSK_03955
MAW: MAC_02797
MAJ: MAA_05263
CMT: CCM_04990
BFU: BCIN_05g03290(Bckex2)
MBE: MBM_03947
ANI: AN3583.2
ANG: ANI_1_1140014(An01g08530)
PTE: PTT_12023
ZTR: MYCGRDRAFT_10819(MgSPR2)
SPO: SPAC22E12.09c(krp1)
CNE: CNH01120
CNB: CNBL1060
ABP: AGABI1DRAFT52884(AGABI1DRAFT_52884)
ABV: AGABI2DRAFT199236(AGABI2DRAFT_199236)
MGL: MGL_3817
 » show all
Taxonomy
Reference
1  [PMID:6430565]
  Authors
Julius D, Brake A, Blair L, Kunisawa R, Thorner J.
  Title
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor.
  Journal
Cell 37:1075-89 (1984)
DOI:10.1016/0092-8674(84)90442-2
Reference
2  [PMID:3894003]
  Authors
Achstetter T, Wolf DH.
  Title
Hormone processing and membrane-bound proteinases in yeast.
  Journal
EMBO J 4:173-7 (1985)
Reference
3  [PMID:2845974]
  Authors
Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H.
  Title
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases.
  Journal
Biochem Biophys Res Commun 156:246-54 (1988)
DOI:10.1016/S0006-291X(88)80832-5
  Sequence
[sce:YNL238W]
Reference
4  [PMID:2646633]
  Authors
Fuller RS, Brake A, Thorner J.
  Title
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
  Journal
Proc Natl Acad Sci U S A 86:1434-8 (1989)
DOI:10.1073/pnas.86.5.1434
  Sequence
[sce:YNL238W]
Reference
5  [PMID:2647083]
  Authors
Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H
  Title
Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae.
  Journal
Biochem Biophys Res Commun 159:305-11 (1989)
DOI:10.1016/0006-291X(89)92438-8
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.61
IUBMB Enzyme Nomenclature: 3.4.21.61
ExPASy - ENZYME nomenclature database: 3.4.21.61
BRENDA, the Enzyme Database: 3.4.21.61
CAS: 99676-46-7

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