| Entry |
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| Name |
pancreatic endopeptidase E;
cholesterol-binding proteinase;
proteinase E;
cholesterol-binding serine proteinase;
pancreatic protease E;
pancreatic proteinase E;
cholesterol-binding pancreatic proteinase;
CBPP;
pancreas E proteinase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
 |
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| Reaction(IUBMB) |
Preferential cleavage: Ala!. Does not hydrolyse elastin
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| Comment |
A peptidase of family S1 (trypsin family) from pancreatic juice. Unlike elastases, has an acidic pI. Binds cholesterol
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| History |
EC 3.4.21.70 created 1992
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| Orthology |
| K01345 | pancreatic endopeptidase E |
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| Genes |
» show all
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| Reference |
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| Authors |
Mallory PA, Travis J. |
|---|
| Title |
Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase. |
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| Journal |
Biochemistry 14:722-30 (1975) |
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| Reference |
|
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| Authors |
Shen WF, Fletcher TS, Largman C. |
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| Title |
Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.70 |
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