KEGG   ENZYME: 3.4.21.70Help
Entry
EC 3.4.21.70                Enzyme                                 

Name
pancreatic endopeptidase E;
cholesterol-binding proteinase;
proteinase E;
cholesterol-binding serine proteinase;
pancreatic protease E;
pancreatic proteinase E;
cholesterol-binding pancreatic proteinase;
CBPP;
pancreas E proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Ala!. Does not hydrolyse elastin
Comment
A peptidase of family S1 (trypsin family) from pancreatic juice. Unlike elastases, has an acidic pI. Binds cholesterol
History
EC 3.4.21.70 created 1992
Orthology
K01345  pancreatic endopeptidase E
Genes
HSA: 10136(CELA3A) 23436(CELA3B)
PTR: 456491 749169(CELA3A)
PPS: 100969372(CELA3A)
GGO: 101137143(CELA3B)
PON: 100439784(CELA3B) 103888935(CELA3A)
NLE: 100596417(CELA3A) 100603679(CELA3B)
MCC: 574236(CELA3B)
MCF: 102144846(CELA3B)
CSAB: 103225426
RRO: 104663219
RBB: 108538450
CJC: 100386418(CELA3B)
SBQ: 101051739(CELA3B)
MMU: 67868(Cela3b)
RNO: 298567(Cela3b)
CGE: 100765144
NGI: 103746435
HGL: 101701010(Cela3b)
CCAN: 109694914 109694922(Cela3b)
OCU: 100338830 100339081 100339326 100339575 100339830 100348247 100348913 100349163 103350299 103350310
TUP: 102489028(CELA3B)
CFA: 478196
AML: 100464577
UMR: 103666796
ORO: 101363663(CELA3B)
FCA: 101094275
PTG: 102948913(CELA3B)
AJU: 106977605
BTA: 281752(CELA3B)
BOM: 102267066
BIU: 109576143
PHD: 102323552
CHX: 102188098
OAS: 101103454
SSC: 110261434
CFR: 102514000(CELA3B)
CDK: 105088866
BACU: 103008517(CELA3B)
LVE: 103088740(CELA3B)
OOR: 101269800
ECB: 100071692
EPZ: 103558480
EAI: 106840005
MYB: 102258274(CELA3B)
MYD: 102758633(CELA3B)
HAI: 109396740(CELA3B)
RSS: 109434431
PALE: 102889614
LAV: 100668364
TMU: 101340821
MDO: 100026235(CELA3B)
SHR: 100925777(CELA3B)
GGA: 100857116(CELA3B)
MGP: 100549082
CJO: 107323307(CELA3B)
APLA: 101793005
ACYG: 106048620
GFR: 102033802
FAB: 101821426
PHI: 102106956(CELA3B)
PMAJ: 107213557(CELA3B)
CCAE: 111938541
FPG: 101919146
FCH: 102046704
CLV: 102093106
PSS: 106732719
CMY: 102939403(CELA3B)
CPIC: 101931240(CELA3B)
ACS: 100556283 103281670
PVT: 110073187 110073188
PBI: 103054366
GJA: 107111587 107111618
XLA: 108695955 443664(cela3a.S) 447029(cela3b.L)
XTR: 100494627 101734670 101734861 496902(ela3b) 496909(cela3a)
NPR: 108803238
IPU: 108275518(Cela3b)
AMEX: 103041381
TRU: 101069690 101071304
TNG: GSTEN00026615G001
LCO: 104919063 104929218 104929223 104931542
NCC: 104941139 104959852
MZE: 101482931
XMA: 102216966 102226343
PRET: 103463870 103479654
NFU: 107383903 107393374
KMR: 108239564 108240172
CSEM: 103396268
LCF: 108878838 108879544 108883404
SDU: 111227518 111231094 111231831
HCQ: 109520820
BPEC: 110154882 110159546
MALB: 109962099
SASA: 100196335(cac3)
OTW: 112248933
ELS: 105011802 105020175
LCM: 102347653
CMK: 103181355
ADF: 107347515
HMG: 100208251
 » show all
Taxonomy
Reference
1  [PMID:234742]
  Authors
Mallory PA, Travis J.
  Title
Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase.
  Journal
Biochemistry 14:722-30 (1975)
Reference
2  [PMID:3477287]
  Authors
Shen WF, Fletcher TS, Largman C.
  Title
Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA.
  Journal
Biochemistry 26:3447-52 (1987)
DOI:10.1021/bi00386a030
  Sequence
[hsa:23436]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.70
IUBMB Enzyme Nomenclature: 3.4.21.70
ExPASy - ENZYME nomenclature database: 3.4.21.70
BRENDA, the Enzyme Database: 3.4.21.70
CAS: 68073-27-8

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Gene (917)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (137)   
   KEGG MGENES (16)   
   RefGene (763)   
Protein sequence (16)   
   UniProt (4)   
   SWISS-PROT (4)   
   RefSeq(pep) (8)   
DNA sequence (11)   
   RefSeq(nuc) (8)   
   GenBank (2)   
   EMBL (1)   
All databases (944)   

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