KEGG   ENZYME: 3.4.21.72Help
Entry
EC 3.4.21.72                Enzyme                                 

Name
IgA-specific serine endopeptidase;
IgA protease;
IgA proteinase;
IgA-specific proteinase;
immunoglobulin A protease;
immunoglobulin A proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of immunoglobulin A molecules at certain Pro! bonds in the hinge region. No small molecule substrates are known
Comment
Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase)
History
EC 3.4.21.72 created 1992
Orthology
K01347  IgA-specific serine endopeptidase
Genes
HIN: HI0990(iga1)
HIT: NTHI0354(hap) NTHI1164(iga1)
HIP: CGSHiEE_07015(recF)
HIF: HIBPF_12570
HIL: HICON_04100
HIU: HIB_03070 HIB_11300(iga)
HIE: R2846_0355(hap1) R2846_1321(iga)
HIZ: R2866_0337(hap1) R2866_1393(iga)
HIK: HifGL_000025(hap) HifGL_000617(iga)
HIA: H733_0142 H733_1448
MHX: MHH_c09480(hap1) MHH_c11330(iga1) MHH_c11860(iga2) MHH_c14860
BTO: WQG_4340
BTRE: F542_17690
BTRH: F543_19470
BTRA: F544_4640
NME: NMB0700(iga) NMB1985(hap) NMB1998
NMW: NMAA_0168(app) NMAA_0537(iga)
NMC: NMC0651(iga) NMC1959(iga2)
NMN: NMCC_0223(app) NMCC_0659(iga)
NMT: NMV_1699(iga) NMV_2184(app)
NMI: NMO_0169 NMO_0193(iga2) NMO_0592(iga1)
NLA: NLA_19200(iga2)
LLM: llmg_0877
 » show all
Taxonomy
Reference
1  [PMID:6416146]
  Authors
Plaut AG.
  Title
The IgA1 proteases of pathogenic bacteria.
  Journal
Annu Rev Microbiol 37:603-22 (1983)
DOI:10.1146/annurev.mi.37.100183.003131
Reference
2  [PMID:2105953]
  Authors
Bachovchin WW, Plaut AG, Flentke GR, Lynch M, Kettner CA.
  Title
Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids.
  Journal
J Biol Chem 265:3738-43 (1990)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.72
IUBMB Enzyme Nomenclature: 3.4.21.72
ExPASy - ENZYME nomenclature database: 3.4.21.72
BRENDA, the Enzyme Database: 3.4.21.72
CAS: 55127-02-1

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