| Entry |
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| Name |
u-plasminogen activator;
urokinase;
urinary plasminogen activator;
cellular plasminogen activator;
urokinase-type plasminogen activator;
double-chain urokinase-type plasminogen activator;
two-chain urokinase-type plasminogen activator;
urokinase plasminogen activator;
uPA;
u-PA;
abbokinase;
urinary esterase A
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Specific cleavage of Arg!Val bond in plasminogen to form plasmin
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| Comment |
Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26
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| History |
EC 3.4.21.73 created 1972 as EC 3.4.99.26, transferred 1978 as EC 3.4.21.31, part transferred 1992 to EC 3.4.21.73
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| Orthology |
| K01348 | urokinase plasminogen activator |
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| Genes |
» show all
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| Reference |
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| Authors |
Lottenberg R, Christensen U, Jackson CM, Coleman PL. |
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| Title |
Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates. |
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| Journal |
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| Reference |
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| Authors |
Loskutoff DJ, Schleef RR. |
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| Title |
Plasminogen activators and their inhibitors. |
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| Journal |
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| Reference |
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| Authors |
Saksela O, Rifkin DB. |
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| Title |
Cell-associated plasminogen activation: regulation and physiological functions. |
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| Journal |
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| Reference |
4 |
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| Authors |
Collen, D., Lijnen, H. R. and Verstraete, M. |
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| Title |
The fibrinolytic system and its disorders. |
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| Journal |
In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.), Blood: Principles and Practice of Hematology, 2nd ed., J.B.Lippincott Company, Philadelphia, 1990 |
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| Reference |
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| Authors |
Lijnen HR, Van Hoef B, Nelles L, Collen D. |
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| Title |
Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740----Ala) and plasmin-resistant scu-PA (Lys158----Glu). |
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| Journal |
J Biol Chem 265:5232-6 (1990) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.73 |
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