KEGG   ENZYME: 3.4.21.77
Entry
EC 3.4.21.77                Enzyme                                 
Name
semenogelase;
prostate-specific antigen;
alpha-seminoprotein;
seminin;
P-30 antigen;
antigen (human clone HPSA-1 prostate-specific protein moiety reduced);
gamma-seminoglycoprotein (human protein moiety reduced);
gamma-SM;
antigen PSA (human prostate-specific);
human glandular kallikrein;
antigen PSA (human clone 5P1 protein moiety reduced)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: -Tyr!
Comment
A peptidase of family S1 (trypsin family) from seminal plasma. Slowly inhibited by alpha1-antichymotrypsin
History
EC 3.4.21.77 created 1993
Orthology
K01351  semenogelase
Genes
HSA: 354(KLK3)
PTR: 493182(KLK3)
PPS: 100996069(KLK3)
GGO: 101143851(KLK3)
PON: 100432364(KLK3)
PPYG: 129020783(KLK3)
NLE: 100585512
HMH: 116478137(KLK3)
SSYN: 129460307
MCC: 719444(KLK3)
MCF: 102138599(KLK3)
MTHB: 126943121
MNI: 105497141
CSAB: 103235103(KLK3)
CATY: 105595343(KLK3)
PANU: 100127349(KLK3)
TGE: 112613502
MLEU: 105528939(KLK3)
RRO: 104667244
RBB: 108532415(KLK3)
TFN: 117091652
PTEH: 111519951(KLK3)
CANG: 105514724
 » show all
Reference
1  [PMID:2467258]
  Authors
Digby M, Zhang XY, Richards RI.
  Title
Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1.
  Journal
Nucleic Acids Res 17:2137 (1989)
DOI:10.1093/nar/17.5.2137
  Sequence
[hsa:354]
Reference
2  [PMID:1702714]
  Authors
Christensson A, Laurell CB, Lilja H.
  Title
Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors.
  Journal
Eur J Biochem 194:755-63 (1990)
DOI:10.1111/j.1432-1033.1990.tb19466.x
  Sequence
[hsa:354]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.77
IUBMB Enzyme Nomenclature: 3.4.21.77
ExPASy - ENZYME nomenclature database: 3.4.21.77
BRENDA, the Enzyme Database: 3.4.21.77
CAS: 110157-83-0 95829-41-7

  All links  
Gene (24)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (23)   
Protein sequence (30)   
   UniProt (3)   
   SWISS-PROT (3)   
   RefSeq(pep) (4)   
   PDBSTR (20)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
3D Structure (4)   
   PDB (4)   
Protein domain (6)   
   InterPro (6)   
All databases (69)   

Download RDF
DBGET integrated database retrieval system