KEGG   ENZYME: 3.4.21.78Help
Entry
EC 3.4.21.78                Enzyme                                 

Name
granzyme A;
CTLA3;
HuTPS;
T-cell associated protease 1;
cytotoxic T lymphocyte serine protease;
TSP-1;
T-cell derived serine proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg!, -Lys! >> -Phe! in small molecule substrates
Comment
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe!-
History
EC 3.4.21.78 created 1993
Orthology
K01352  granzyme A
Genes
HSA: 3001(GZMA)
PTR: 461873(GZMA)
PPS: 100984053(GZMA)
GGO: 101143719(GZMA)
PON: 100445064(GZMA)
NLE: 100604986(GZMA)
MCC: 705712(GZMA)
MCF: 102143423(GZMA)
CSAB: 103221481(GZMA)
RRO: 104680493(GZMA)
RBB: 108530978(GZMA)
CJC: 100408119(GZMA)
SBQ: 101036387(GZMA)
MMU: 14938(Gzma)
RNO: 266708(Gzma)
NGI: 103739933(Gzma) 103739934
HGL: 101726631(Gzma)
TUP: 102467739(GZMA)
CFA: 487207(GZMA)
AML: 100476014(GZMA)
UMR: 103663680(GZMA)
ORO: 101372849(GZMA)
FCA: 100113480(GZMA)
PTG: 102949286(GZMA)
AJU: 106987310(GZMA)
BTA: 407178(gzmA) 539093(GZMA)
BIU: 109574751 109575058(GZMA)
CHX: 102168390(GZMA) 102184761
SSC: 100233183(GZMA) 100526762(GZMA)
ECB: 100062497(GZMA)
EPZ: 103559058(GZMA)
EAI: 106843354(GZMA)
MYB: 102250453(GZMA)
MYD: 102761771(GZMA)
HAI: 109382131(GZMA)
RSS: 109453288(GZMA)
MDO: 100031794(GZMA)
SHR: 100932934(GZMA)
GGA: 395108(GZMA)
MGP: 100549545
CJO: 107306002
ACYG: 106035576
TGU: 100225754(GZMA)
GFR: 102045402(GZMA) 106631840
FAB: 101821368(GZMA)
PHI: 102106832(GZMA)
PMAJ: 107198458(GZMA)
CCAE: 111941375
FPG: 101912239(GZMA) 101915064
FCH: 102052542(GZMA) 102053870
EGZ: 104134695
ASN: 102381782
AMJ: 102558867(GZMA)
PSS: 102462891(GZMA)
CMY: 102931660(GZMA)
CPIC: 101935187(GZMA)
ACS: 100557669
PBI: 103049382
XLA: 108718387(gzmak.L) 379554(gzma.S) 398620(gzmak.S) 494696(gzma.L)
XTR: 100135014(gzma) 100497188(gzmak)
TRU: 101067058
LCO: 104934136
NCC: 104947021
OLA: 101173066
NFU: 107377780
CSEM: 103397912
LCF: 108881328
SDU: 111236503
BPEC: 110165459
MALB: 109956500
SASA: 100196008(graa) 106570903(GRAA)
OTW: 112263954
 » show all
Taxonomy
Reference
1  [PMID:3545816]
  Authors
Simon MM, Hoschutzky H, Fruth U, Simon HG, Kramer MD.
  Title
Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.
  Journal
EMBO J 5:3267-74 (1986)
Reference
2  [PMID:3257574]
  Authors
Gershenfeld HK, Hershberger RJ, Shows TB, Weissman IL.
  Title
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.
  Journal
Proc Natl Acad Sci U S A 85:1184-8 (1988)
DOI:10.1073/pnas.85.4.1184
  Sequence
[hsa:3001]
Reference
3  [PMID:1998680]
  Authors
Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC.
  Title
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
  Journal
Biochemistry 30:2217-27 (1991)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.78
IUBMB Enzyme Nomenclature: 3.4.21.78
ExPASy - ENZYME nomenclature database: 3.4.21.78
BRENDA, the Enzyme Database: 3.4.21.78
CAS: 143180-73-8

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