KEGG   ENZYME: 3.4.21.79Help
Entry
EC 3.4.21.79                Enzyme                                 

Name
granzyme B;
CTLA1;
CCPII;
cytotoxic cell proteinase-1;
granzyme G;
granzyme H;
CCP1 proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: -Asp! >> -Asn! > -Met!, -Ser!
Comment
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family)
History
EC 3.4.21.79 created 1993
Orthology
K01353  granzyme B
Genes
HSA: 3002(GZMB)
PTR: 452825(GZMB)
PPS: 100987153(GZMB)
GGO: 101133374(GZMB)
PON: 100432682
NLE: 100604300(GZMH)
MCC: 716518(GZMB)
MCF: 102130260(GZMB)
CSAB: 103228744(GZMB)
RRO: 104662660(GZMB)
RBB: 108515190(GZMB)
CJC: 100389206(GZMB)
SBQ: 101039443(GZMB)
MMU: 14939(Gzmb)
RNO: 100361468(Gzmbl2) 171528(Gzmb)
HGL: 101702156(Gzmb)
CFA: 490630
AML: 100464420
UMR: 103679303
FCA: 100127106(GZMB)
PTG: 102957957(GZMB) 102967670
SSC: 100233184(GZMB) 100739080
CFR: 102518030 102518273(GZMB)
CDK: 105094200(GZMB) 105106640
BACU: 103000247 103010961(GZMB)
LVE: 103087729(GZMB) 103088275
OOR: 101287187
MDO: 100015759(GZMB)
OAA: 791103(GZMB)
AMJ: 102574848(GZMB)
XLA: 108704981
NPR: 108788431
DRE: 100000986(gzm3) 100001138(gzm3.3)
IPU: 100304651(Gzmf) 108267046
TRU: 101070721
HCQ: 109523326
BPEC: 110156126
OTW: 112251797
ELS: 105011524 105029813(cma1)
LCM: 102345749
 » show all
Taxonomy
Reference
1  [PMID:2953813]
  Authors
Schmid J, Weissmann C.
  Title
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.
  Journal
J Immunol 139:250-6 (1987)
  Sequence
[hsa:3002]
Reference
2  [PMID:1998680]
  Authors
Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC.
  Title
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
  Journal
Biochemistry 30:2217-27 (1991)
Reference
3  [PMID:1985927]
  Authors
Poe M, Blake JT, Boulton DA, Gammon M, Sigal NH, Wu JK, Zweerink HJ.
  Title
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.
  Journal
J Biol Chem 266:98-103 (1991)
  Sequence
[hsa:3002]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.79
IUBMB Enzyme Nomenclature: 3.4.21.79
ExPASy - ENZYME nomenclature database: 3.4.21.79
BRENDA, the Enzyme Database: 3.4.21.79
CAS: 143180-74-9

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