KEGG   ENZYME: 3.4.21.93Help
Entry
EC 3.4.21.93                Enzyme                                 

Name
proprotein convertase 1;
prohormone convertase 3;
neuroendocrine convertase 1;
PC1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg! bonds
Comment
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family)
History
EC 3.4.21.93 created 1996
Orthology
K01359  proprotein convertase subtilisin/kexin type 1
Genes
HSA: 5122(PCSK1)
PTR: 461740(PCSK1)
PPS: 100988619(PCSK1)
GGO: 101129039(PCSK1)
PON: 100173253(PCSK1)
NLE: 100606392(PCSK1)
MCC: 699742(PCSK1)
MCF: 102142243(PCSK1)
CSAB: 103224951(PCSK1)
RRO: 104654548(PCSK1)
RBB: 108520341(PCSK1)
CJC: 100403507(PCSK1)
SBQ: 101042932(PCSK1)
MMU: 18548(Pcsk1)
RNO: 100911216 25204(Pcsk1)
CGE: 100757402(Pcsk1)
NGI: 103729900(Pcsk1)
HGL: 101704290(Pcsk1)
CCAN: 109684716(Pcsk1)
OCU: 100345424(PCSK1)
TUP: 102471290(PCSK1)
CFA: 479149(PCSK1)
AML: 100484463(PCSK1)
UMR: 103672232(PCSK1)
ORO: 101371118(PCSK1)
FCA: 101082627(PCSK1)
PTG: 102971097(PCSK1)
AJU: 106969006(PCSK1)
BTA: 281967(PCSK1)
BOM: 102266289(PCSK1)
BIU: 109562342(PCSK1)
PHD: 102340197(PCSK1)
CHX: 102184429(PCSK1)
OAS: 443029(PCSK1)
SSC: 397103(PCSK1)
CFR: 102510598(PCSK1)
CDK: 105100892(PCSK1)
BACU: 103011823(PCSK1)
LVE: 103072078(PCSK1)
OOR: 101287435(PCSK1)
ECB: 100064886(PCSK1)
EPZ: 103560422(PCSK1)
EAI: 106847921(PCSK1)
MYB: 102259719(PCSK1)
MYD: 102763458(PCSK1)
HAI: 109390165(PCSK1)
RSS: 109445495(PCSK1)
PALE: 102890971(PCSK1)
LAV: 100677414(PCSK1)
TMU: 101353481
MDO: 100010673(PCSK1)
SHR: 100925062(PCSK1)
OAA: 100081484(PCSK1)
GGA: 769230(PCSK1)
MGP: 100547608(PCSK1)
CJO: 107306483(PCSK1)
APLA: 101796157(PCSK1)
ACYG: 106048829(PCSK1)
TGU: 100226064(PCSK1)
GFR: 102042035(PCSK1)
FAB: 101816616(PCSK1)
PHI: 102111185(PCSK1)
PMAJ: 107198324(PCSK1)
CCW: 104689825(PCSK1)
FPG: 101913861(PCSK1)
FCH: 102048239(PCSK1)
CLV: 102092106(PCSK1)
EGZ: 104122051(PCSK1)
AAM: 106485770 106488897(PCSK1)
ASN: 102377633(PCSK1)
AMJ: 102564458(PCSK1)
PSS: 102461055(PCSK1)
CMY: 102934087(PCSK1)
CPIC: 101938233(PCSK1)
ACS: 100565158(pcsk1)
PVT: 110078772(PCSK1)
PBI: 103055161(PCSK1)
GJA: 107119975(PCSK1)
XLA: 108707229(pcsk1.S)
XTR: 100496933(pcsk1)
NPR: 108790052(PCSK1)
DRE: 100005716(pcsk1)
SGH: 107584544(pcsk1) 107600928
IPU: 108279303(pcsk1)
AMEX: 103035459(pcsk1)
TRU: 101067633(pcsk1) 101070282
LCO: 104928927(pcsk1)
NCC: 104957061(pcsk1)
MZE: 101467660(pcsk1) 105941351
OLA: 101161187 101174018(pcsk1)
XMA: 102231210(pcsk1) 106699876
PRET: 103464990(pcsk1)
NFU: 107385468(pcsk1)
CSEM: 103386425(pcsk1)
LCF: 108899706(pcsk1)
HCQ: 109522656(pcsk1)
BPEC: 110166707(pcsk1)
ELS: 105008684 105016778(pcsk1)
SFM: 108928574(pcsk1) 108937256
LCM: 102356617(PCSK1) 102361804
CMK: 103173148 103178388(pcsk1)
SKO: 100372676
AME: 410438(GB11271)
BIM: 100740253
BTER: 100648653
SOC: 105194699
AEC: 105151284
ACEP: 105618631
PBAR: 105422178
HST: 105186252
CFO: 105256335
LHU: 105675912
PGC: 109854544
NVI: 100115928
TCA: 661661
DPA: 109543176
BMOR: 101741624
PMAC: 106711372
PRAP: 111003596
DNX: 107168153
ZNE: 110838089
FCD: 110863089
TUT: 107362087
BMY: Bm1_29445
CRG: 105344671
MYI: 110462830
ADF: 107358341
HMG: 100205483
 » show all
Taxonomy
Reference
1  [PMID:2169760]
  Authors
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.
  Title
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
  Journal
DNA Cell Biol 9:415-24 (1990)
DOI:10.1089/dna.1990.9.415
  Sequence
[mmu:18548]
Reference
2  [PMID:1988934]
  Authors
Smeekens SP, Avruch AS, LaMendola J, Chan SJ, Steiner DF.
  Title
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
  Journal
Proc Natl Acad Sci U S A 88:340-4 (1991)
DOI:10.1073/pnas.88.2.340
  Sequence
Reference
3  [PMID:1429684]
  Authors
Steiner DF, Smeekens SP, Ohagi S, Chan SJ.
  Title
The new enzymology of precursor processing endoproteases.
  Journal
J Biol Chem 267:23435-8 (1992)
Reference
4  [PMID:7845206]
  Authors
Seidah NG, Chretien M.
  Title
Pro-protein convertases of subtilisin/kexin family.
  Journal
Methods Enzymol 244:175-88 (1994)
DOI:10.1016/0076-6879(94)44015-8
Reference
5  [PMID:7741698]
  Authors
Jean F, Basak A, DiMaio J, Seidah NG, Lazure C.
  Title
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor.
  Journal
Biochem J 307 ( Pt 3):689-95 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.93
IUBMB Enzyme Nomenclature: 3.4.21.93
ExPASy - ENZYME nomenclature database: 3.4.21.93
BRENDA, the Enzyme Database: 3.4.21.93
CAS: 99676-46-7

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