KEGG   ENZYME: 3.4.21.94Help
Entry
EC 3.4.21.94                Enzyme                                 

Name
proprotein convertase 2;
neuroendocrine convertase 2;
PC2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg! bonds
Comment
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)
History
EC 3.4.21.94 created 1996
Orthology
K01360  proprotein convertase subtilisin/kexin type 2
Genes
HSA: 5126(PCSK2)
PTR: 458106(PCSK2)
PPS: 100995237(PCSK2)
GGO: 101144581(PCSK2)
PON: 100171744(PCSK2)
NLE: 100606456(PCSK2)
MCC: 695730(PCSK2)
MCF: 102139968(PCSK2)
CSAB: 103214696(PCSK2)
RRO: 104676602(PCSK2)
RBB: 108544396(PCSK2)
CJC: 100410189(PCSK2)
SBQ: 101032326(PCSK2)
MMU: 18549(Pcsk2)
RNO: 25121(Pcsk2)
CGE: 100771130(Pcsk2)
NGI: 103747731(Pcsk2)
HGL: 101710029(Pcsk2)
CCAN: 109679472(Pcsk2)
OCU: 100358339(PCSK2)
TUP: 102496906(PCSK2)
CFA: 485757(PCSK2)
AML: 100484456(PCSK2)
UMR: 103680513(PCSK2)
ORO: 101380258(PCSK2)
FCA: 101098130(PCSK2)
PTG: 102951344(PCSK2) 107181016
BTA: 281968(PCSK2)
BOM: 102280836(PCSK2)
BIU: 109568044(PCSK2)
PHD: 102340546
CHX: 102179575 106503927(PCSK2)
OAS: 443027(PCSK2)
SSC: 445533(PCSK2)
CFR: 102508845(PCSK2) 102511136
CDK: 105094118(PCSK2)
BACU: 103012983(PCSK2)
LVE: 103076654(PCSK2)
OOR: 101276250(PCSK2)
ECB: 100050755(PCSK2)
EPZ: 103555212 103561885(PCSK2)
EAI: 106823791(PCSK2) 106841498
MYB: 102239561(PCSK2)
MYD: 102759435(PCSK2)
HAI: 109372764(PCSK2)
RSS: 109460857(PCSK2)
PALE: 102879445(PCSK2)
LAV: 100659343(PCSK2)
TMU: 101361430
MDO: 100033262(PCSK2)
SHR: 100925659(PCSK2)
OAA: 100085012(PCSK2)
GGA: 395136(PCSK2)
MGP: 100548840(PCSK2)
CJO: 107310688(PCSK2)
APLA: 101791329(PCSK2)
ACYG: 106048665(PCSK2)
TGU: 100223337(PCSK2)
GFR: 102034686(PCSK2)
FAB: 101808403(PCSK2)
PHI: 102111890(PCSK2)
PMAJ: 107202341(PCSK2)
CCAE: 111926118(PCSK2)
CCW: 104696571(PCSK2)
FPG: 101924281(PCSK2)
FCH: 102046561(PCSK2)
CLV: 102088621(PCSK2)
EGZ: 104122531(PCSK2)
AAM: 106496400(PCSK2)
ASN: 102373017(PCSK2)
AMJ: 102576051(PCSK2)
PSS: 102463058(PCSK2)
CMY: 102939591(PCSK2)
CPIC: 101951129(PCSK2)
ACS: 100564235(pcsk2)
PVT: 110088789(PCSK2)
PBI: 103053916(PCSK2)
GJA: 107116988(PCSK2)
XLA: 373675(pcsk2.L) 444586(pcsk2.S)
XTR: 100036632(pcsk2)
NPR: 108793310(PCSK2)
DRE: 100004460(pcsk2)
SRX: 107719546(pcsk2) 107727889
CCAR: 109050932 109065357(pcsk2)
IPU: 108262286(pcsk2)
AMEX: 103033370(pcsk2)
TRU: 101068590(pcsk2)
LCO: 104930725(pcsk2)
NCC: 104955826(pcsk2)
MZE: 101470601(pcsk2)
OLA: 100049241(pcsk2)
XMA: 102231965(pcsk2)
PRET: 103476807(pcsk2)
NFU: 107376020(pcsk2)
KMR: 108245432(pcsk2)
CSEM: 103387697(pcsk2)
LCF: 108897258(pcsk2)
SDU: 111235221(pcsk2)
HCQ: 109512729(pcsk2)
BPEC: 110157135(pcsk2)
MALB: 109960189(pcsk2)
SASA: 106576998(pcsk2) 106607177(NEC2)
OTW: 112253023(pcsk2) 112254478
ELS: 105010665(pcsk2)
SFM: 108927161(pcsk2) 108933539
LCM: 102352855(PCSK2)
CMK: 103177907(pcsk2)
CIN: 100181292(cipc2)
SPU: 579017(PCSK2)
APLC: 110979638
SKO: 100377458(PCSK2)
DME: Dmel_CG6438(amon)
DSI: Dsimw501_GD18123(Dsim_GD18123)
AAG: 5564601
AME: 408835
BIM: 100742794
BTER: 100643887
SOC: 105203804
AEC: 105147744
ACEP: 105620261
PBAR: 105426716
HST: 105182032
DQU: 106746237
CFO: 105257823
LHU: 105674509
PGC: 109855266
PCF: 106786031
NVI: 100116354
MDL: 103573332
TCA: 661336
DPA: 109535104
BMOR: 101740216
PRAP: 110994302
HAW: 110377468
PXY: 105390833
API: 100167562
ZNE: 110830089
FCD: 110843872
TUT: 107370069
CEL: CELE_C51E3.7(egl-3)
CBR: CBG09536(Cbr-egl-3)
BMY: Bm1_52415
CRG: 105340113
MYI: 110462057
LAK: 106180256
SHX: MS3_05446
EGL: EGR_08746
AQU: 105316000
LIH: L63ED372_02112(prcA)
 » show all
Taxonomy
Reference
1  [PMID:2169760]
  Authors
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.
  Title
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
  Journal
DNA Cell Biol 9:415-24 (1990)
DOI:10.1089/dna.1990.9.415
  Sequence
[mmu:18549]
Reference
2  [PMID:2154467]
  Authors
Smeekens SP, Steiner DF.
  Title
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
  Journal
J Biol Chem 265:2997-3000 (1990)
  Sequence
[hsa:5126]
Reference
3  [PMID:8159732]
  Authors
Rouille Y, Westermark G, Martin SK, Steiner DF.
  Title
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.
  Journal
Proc Natl Acad Sci U S A 91:3242-6 (1994)
DOI:10.1073/pnas.91.8.3242
Reference
4  [PMID:7845206]
  Authors
Seidah NG, Chretien M.
  Title
Pro-protein convertases of subtilisin/kexin family.
  Journal
Methods Enzymol 244:175-88 (1994)
DOI:10.1016/0076-6879(94)44015-8
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.94
IUBMB Enzyme Nomenclature: 3.4.21.94
ExPASy - ENZYME nomenclature database: 3.4.21.94
BRENDA, the Enzyme Database: 3.4.21.94
CAS: 388092-42-0

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