KEGG   ENZYME: 3.4.22.15Help
Entry
EC 3.4.22.15                Enzyme                                 

Name
cathepsin L;
Aldrichina grahami cysteine proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
Comment
A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64
History
EC 3.4.22.15 created 1978 (EC 3.4.99.19 created 1972, incorporated 1981)
Orthology
K01365  cathepsin L
Genes
HSA: 1514(CTSL)
PTR: 473484 737449(CTSL)
PPS: 100987260(CTSL)
GGO: 101143280 101143887 101145975(CTSL) 109025034
PON: 100450374(CTSL)
NLE: 100585562 100604414(CTSL)
MCC: 694569(CTSL)
MCF: 102116556(CTSL)
CSAB: 103219700(CTSL) 103247618
RRO: 104659397 104673720(CTSL)
RBB: 108521156(CTSL) 108543421
SBQ: 101030077(CTSL) 101051131
MMU: 13039(Ctsl)
RNO: 25697(Ctsl)
HGL: 101717733
CFA: 102156614
AML: 100484313(CTSV)
BTA: 281108(CTSV) 515200(CTSL)
BOM: 102269419 102285097(CTSV)
BIU: 109563231(CTSL)
CHX: 102185465(CTSL) 102190225(CTSV)
OAS: 101113725(CTSL) 780510(CTSV)
SSC: 100515919(CTSL) 396926(CTSV)
CFR: 102513187(CTSL) 102515353(CTSV)
CDK: 105084679(CTSV) 105084695(CTSL)
BACU: 103003105(CTSL) 103009986
LVE: 103085310(CTSL) 103089492
OOR: 101285992(CTSL) 101289364
ECB: 100061234 100061532(CTSL)
EPZ: 103550840(CTSL) 103563220
EAI: 106828084 106844429(CTSV)
MDO: 100013197
GGA: 420160 427466(CTSV)
MGP: 100546685(CTSL) 100551338
CJO: 107306273(CTSL) 107325555
APLA: 101790109 101803168(CTSL)
ACYG: 106044971 106045392(CTSL)
TGU: 100226165 100232421(CTSL)
GFR: 102031629(CTSL)
FAB: 101814636(CTSL)
PHI: 102099328(CTSL)
PMAJ: 107198348(CTSL)
CCW: 104692009(CTSL)
FPG: 101912292 101914468(CTSL)
FCH: 102046755 102053586(CTSL)
CLV: 102090299(CTSL) 102096675
EGZ: 104124387 104125939(CTSV)
ASN: 102370520 102383850(CTSL)
AMJ: 102560893 102572965(CTSL)
PSS: 102444883(CTSL) 102463027
CPIC: 101930955 101944587(CTSL)
ACS: 100561941(ctsl) 100563896
XLA: 108711337 444163(ctsl.L) 447313(ctsv.L)
XTR: 448179(ctsv)
DRE: 30443(ctslb) 321453(ctsla) 436641(ctsl.1)
LCF: 108875054 108878360(ctsl)
DME: Dmel_CG11459(CG11459) Dmel_CG6692(Cp1)
DSI: Dsimw501_GD10987(Dsim_GD10987) Dsimw501_GD10995(Dsim_GD10995) Dsimw501_GD19566(Dsim_GD19566) Dsimw501_GD19835(Dsim_GD19835) Dsimw501_GD22268(Dsim_GD22268)
AME: 552756
BIM: 100749528
BTER: 100645780
SOC: 105208238
AEC: 105153750
ACEP: 105622747
PBAR: 105424815
HST: 105191348
BMOR: 693031(Bcp)
PMAC: 106716166
PRAP: 110999694
PXY: 105382819
API: 100166071(Ctsl) 100167920
DNX: 107173596
ZNE: 110836278
CEL: CELE_T03E6.7(cpl-1)
CBR: CBG22599(Cbr-cpl-1)
BMY: Bm1_20385
TSP: Tsp_11596
TCC: 18596710
VRA: 106770536
VAR: 108337678
LJA: Lj0g3v0162449.1(Lj0g3v0162449.1) Lj6g3v1995750.1(Lj6g3v1995750.1) Lj6g3v1995800.1(Lj6g3v1995800.1)
AIP: 110270412
LANG: 109360679
PMUM: 103324881
PAVI: 110756418
ZJU: 107410781
CPEP: 111788438
JRE: 108990419
CANN: 107871500
NTO: 108943964
OEU: 111370082
DCR: 108225102
SOE: 110776408
DOSA: Os04t0650000-01(Os04g0650000)
OBR: 102709319
ATS: 109743204(LOC109743204) 109748138(LOC109748138) 109762805(LOC109762805) 109762807(LOC109762807)
SITA: 101762122
MUS: 103975024
DCT: 110094569
CRE: CHLREDRAFT_155869(CEP2)
MNG: MNEG_0471
APRO: F751_4068
SMIN: v1.2.002365.t1(symbB.v1.2.002365.t1) v1.2.008591.t1(symbB.v1.2.008591.t1) v1.2.014138.t1(symbB.v1.2.014138.t1) v1.2.015456.t1(symbB.v1.2.015456.t1) v1.2.018196.t1(symbB.v1.2.018196.t1) v1.2.027498.t1(symbB.v1.2.027498.t1)
 » show all
Taxonomy
Reference
1  [PMID:7043200]
  Authors
Barrett AJ, Kirschke H.
  Title
Cathepsin B, Cathepsin H, and cathepsin L.
  Journal
Methods Enzymol 80 Pt C:535-61 (1981)
Reference
2
  Authors
Barrett, A.J., Buttle, D.J. and Mason, R.W.
  Title
Lysosomal cysteine proteinases.
  Journal
ISI Atlas of Science Biochemistry 1:256-260 (1988)
Reference
3  [PMID:2835398]
  Authors
Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP.
  Title
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.
  Journal
J Clin Invest 81:1621-9 (1988)
DOI:10.1172/JCI113497
  Sequence
[hsa:1514] [mmu:13039]
Reference
4  [PMID:3342870]
  Authors
Kirschke H, Wikstrom P, Shaw E.
  Title
Active center differences between cathepsins L and B: the S1 binding region.
  Journal
FEBS Lett 228:128-30 (1988)
DOI:10.1016/0014-5793(88)80600-8
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.15
IUBMB Enzyme Nomenclature: 3.4.22.15
ExPASy - ENZYME nomenclature database: 3.4.22.15
BRENDA, the Enzyme Database: 3.4.22.15
CAS: 60616-82-2

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