fruit bromelain FA2
Acting on peptide bonds (peptidases);
Hydrolysis of proteins with broad specificity for peptide bonds. Bz-Phe-Val-Arg!NHMec is a good synthetic substrate, but there is no action on Z-Arg-Arg-NHMec (c.f. stem bromelain)
From the pineapple plant, Ananas comosus. Scarcely inhibited by chicken cystatin. Another cysteine endopeptidase, with similar action on small molecule substrates, pinguinain, is obtained from the related plant, Bromelia pinguin, but pinguinain differs from fruit bromelain in being inhibited by chicken cystatin .
EC 18.104.22.168 created 1965 as EC 22.214.171.124, transferred 1972 to EC 126.96.36.199, part transferred 1992 to EC 188.8.131.52