KEGG   ENZYME: 3.4.22.38Help
Entry
EC 3.4.22.38                Enzyme                                 

Name
cathepsin K;
cathepsin O and cathepsin X (both misleading, having been used for other enzymes);
cathepsin O2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg
Comment
Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family)
History
EC 3.4.22.38 created 1997
Orthology
K01371  cathepsin K
Genes
HSA: 1513(CTSK)
PTR: 457278(CTSK)
PPS: 100974656(CTSK)
GGO: 101145486(CTSK) 109025895
PON: 100432447(CTSK)
NLE: 100580351(CTSK)
MCC: 574112(CTSK)
MCF: 102120416(CTSK)
CSAB: 103247207(CTSK)
RRO: 104681068(CTSK)
RBB: 108533261(CTSK)
CJC: 100410169(CTSK)
SBQ: 101045222(CTSK)
MMU: 13038(Ctsk)
RNO: 29175(Ctsk)
CGE: 100765407(Ctsk)
NGI: 103729102(Ctsk)
HGL: 101716993(Ctsk)
CCAN: 109681204(Ctsk)
OCU: 100009334(CTSK)
TUP: 102469152(CTSK)
CFA: 608843(CTSK)
AML: 100483004(CTSK)
UMR: 103667534(CTSK)
ORO: 101371209(CTSK)
FCA: 101093379(CTSK)
PTG: 102968588(CTSK)
AJU: 106979872(CTSK)
BTA: 513038(CTSK)
BOM: 102287709(CTSK)
BIU: 109555331(CTSK)
PHD: 102332396(CTSK)
CHX: 102183473(CTSK)
OAS: 101108972(CTSK)
SSC: 397569(CTSK)
CFR: 102511322(CTSK)
CDK: 105103193(CTSK)
BACU: 103008252(CTSK)
LVE: 103075087(CTSK)
OOR: 101270188(CTSK)
ECB: 100054991(CTSK)
EPZ: 103547638(CTSK)
EAI: 106846533(CTSK)
MYB: 102259503(CTSK)
MYD: 102771486(CTSK)
HAI: 109372279(CTSK)
RSS: 109451622(CTSK)
PALE: 102885198(CTSK)
LAV: 100673950(CTSK)
TMU: 101349596
MDO: 100017449(CTSK)
SHR: 100917440(CTSK)
OAA: 100088286(CTSK)
GGA: 395818(CTSK)
MGP: 104914440(CTSK)
APLA: 101794155(CTSK)
ACYG: 106049270(CTSK)
GFR: 102031691(CTSK)
PHI: 102102166(CTSK)
PMAJ: 107214633(CTSK)
CCAE: 111939475(CTSK)
FPG: 101919682(CTSK)
FCH: 102049655(CTSK)
CLV: 102096035(CTSK)
EGZ: 104132598
AAM: 106495413(CTSK)
ASN: 112547876(CTSK)
AMJ: 109281035(CTSK)
ACS: 100561728(ctsk)
PVT: 110079243 110081453(CTSK)
PBI: 103053602(CTSK)
GJA: 107120548(CTSK)
XTR: 100490139 100492634 448216(ctsk) 779889(ctsk)
DRE: 550475(ctsk)
IPU: 100528180(catk) 108274827(ctssa)
AMEX: 103044235
TRU: 101066261(ctsk)
LCO: 104923938(ctsk)
XMA: 102230067
PRET: 103477640
NFU: 107379225
KMR: 108243181
CSEM: 103388696
BPEC: 110170731
SASA: 100195370(catk) 106580864
ELS: 105009269
LCM: 102352136(CTSK)
DME: Dmel_CG4847(CG4847)
ACEP: 105627376
DQU: 106741339
PCF: 106790486
BMY: Bm1_13265
LAK: 106167228
EGL: EGR_02195
CIT: 102620117
ATR: 18442240
DFA: DFA_03112
 » show all
Taxonomy
Reference
1  [PMID:7818555]
  Authors
Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T.
  Title
Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.
  Journal
Biochem Biophys Res Commun 206:89-96 (1995)
DOI:10.1006/bbrc.1995.1013
  Sequence
[hsa:1513]
Reference
2  [PMID:8647860]
  Authors
Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA.
  Title
Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.
  Journal
J Biol Chem 271:12517-24 (1996)
DOI:10.1074/jbc.271.21.12517
Reference
3  [PMID:8670136]
  Authors
Bromme D, Klaus JL, Okamoto K, Rasnick D, Palmer JT.
  Title
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.
  Journal
Biochem J 315 ( Pt 1):85-9 (1996)
Reference
4  [PMID:9033588]
  Authors
Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS.
  Title
Crystal structure of human osteoclast cathepsin K complex with E-64.
  Journal
Nat Struct Biol 4:109-11 (1997)
Reference
5  [PMID:9033587]
  Authors
McGrath ME, Klaus JL, Barnes MG, Bromme D.
  Title
Crystal structure of human cathepsin K complexed with a potent inhibitor.
  Journal
Nat Struct Biol 4:105-9 (1997)
  Sequence
[hsa:1513]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.38
IUBMB Enzyme Nomenclature: 3.4.22.38
ExPASy - ENZYME nomenclature database: 3.4.22.38
BRENDA, the Enzyme Database: 3.4.22.38
CAS: 94716-09-3

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