KEGG   ENZYME: 3.4.22.41Help
Entry
EC 3.4.22.41                Enzyme                                 

Name
cathepsin F
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L
Comment
Cathepsin F is a lysosomal cysteine endopeptidase of family C1 (papain family), most active at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3
History
EC 3.4.22.41 created 2000
Orthology
K01373  cathepsin F
Genes
HSA: 8722(CTSF)
PTR: 746579(CTSF)
PPS: 100975299(CTSF)
GGO: 101129359(CTSF)
PON: 100439389(CTSF)
NLE: 100597028(CTSF)
MCC: 713743(CTSF)
MCF: 102124998(CTSF)
CSAB: 103222435(CTSF)
RRO: 104664768(CTSF)
RBB: 108518671(CTSF)
CJC: 100398631(CTSF)
SBQ: 101029299(CTSF)
MMU: 56464(Ctsf)
RNO: 361704(Ctsf)
CGE: 100756958(Ctsf)
NGI: 103725560(Ctsf)
HGL: 101719972(Ctsf)
CCAN: 109687122(Ctsf)
OCU: 100101596(CTSF)
TUP: 102480161(CTSF)
CFA: 476010(CTSF)
AML: 100483888(CTSF)
UMR: 103679601(CTSF)
ORO: 101365457(CTSF)
FCA: 101099835(CTSF)
PTG: 102948473(CTSF)
AJU: 106971117(CTSF)
BTA: 509715(CTSF)
BOM: 102282298(CTSF)
BIU: 109554136(CTSF)
PHD: 102336699(CTSF)
CHX: 102178045(CTSF)
OAS: 780471(CTSF)
SSC: 100520004(CTSF)
CFR: 102505263(CTSF)
CDK: 105104453(CTSF)
BACU: 103010911(CTSF)
LVE: 103073241(CTSF)
OOR: 101278493(CTSF)
ECB: 100058569(CTSF)
EPZ: 103559688(CTSF)
EAI: 106833524(CTSF)
MYB: 102241833(CTSF)
MYD: 102766674(CTSF)
HAI: 109384299(CTSF)
PALE: 102897590(CTSF)
LAV: 100676928(CTSF)
TMU: 101350738
MDO: 100029564(CTSF)
SHR: 100927375(CTSF)
ASN: 102372605
AMJ: 102558774(CTSF)
PSS: 102454736
CMY: 102938008
CPIC: 101935122(CTSF)
ACS: 103283025
PVT: 110088139(CTSF)
GJA: 107107966(CTSF)
XLA: 108713957(ctsf.L)
XTR: 100127591(ctsf)
NPR: 108801968
DRE: 565588(ctsf)
IPU: 108268834(ctsw)
AMEX: 103042155
TRU: 101075977(ctsw)
LCO: 104939385(ctsf)
NCC: 104942321(ctsw)
MZE: 101469506
OLA: 101161416
XMA: 102233955
PRET: 103471043
NFU: 107381272
KMR: 108237985
CSEM: 103391298
LCF: 108878763
SDU: 111226593
HCQ: 109515785
BPEC: 110153922
MALB: 109957609
SASA: 100195177(ctsw) 106612102(CATF)
ELS: 105026738
SFM: 108925299
LCM: 102345521 102362412(CTSW)
CIN: 100175491
SPU: 586859
APLC: 110988372
SKO: 100368277
DME: Dmel_CG12163(CG12163)
DSI: Dsimw501_GD19635(Dsim_GD19635)
MDE: 101890771
AME: 408851
BIM: 100745708
BTER: 100652275
SOC: 105202727
AEC: 105144905
ACEP: 105620305
PBAR: 105426056
HST: 105186896
DQU: 106751610
CFO: 105253881
LHU: 105672877
PGC: 109858737
PCF: 106794009
NVI: 100123649
MDL: 103573287
TCA: 662417
DPA: 109546888
NVL: 108567845
BMOR: 101741510
API: 100158959(Ctsf)
DNX: 107162259
CLEC: 106666171
ZNE: 110831681
FCD: 110859207
CEL: CELE_F41E6.6(tag-196)
CBR: CBG01480(Cbr-tag-196)
SHX: MS3_01705
EPA: 110235917
AQU: 100631657
LJA: Lj0g3v0259509.1(Lj0g3v0259509.1) Lj0g3v0259509.2(Lj0g3v0259509.2) Lj0g3v0314599.1(Lj0g3v0314599.1) Lj1g3v2140860.1(Lj1g3v2140860.1) Lj3g3v0129310.1(Lj3g3v0129310.1) Lj3g3v0129320.1(Lj3g3v0129320.1) Lj3g3v3375960.1(Lj3g3v3375960.1) Lj3g3v3375970.1(Lj3g3v3375970.1) Lj5g3v1794680.1(Lj5g3v1794680.1)
DOSA: Os02t0469600-01(Os02g0469600) Os04t0311400-01(Os04g0311400) Os07t0480900-01(Os07g0480900)
ATS: 109734944(LOC109734944) 109740709(LOC109740709) 109764551(LOC109764551)
MIS: MICPUN_98307(CP)
DFA: DFA_10113
SMIN: v1.2.007447.t1(symbB.v1.2.007447.t1)
 » show all
Taxonomy
Reference
1  [PMID:10318784]
  Authors
Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C.
  Title
Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain.
  Journal
J Biol Chem 274:13800-9 (1999)
DOI:10.1074/jbc.274.20.13800
  Sequence
[hsa:8722] [mmu:56464]
Reference
2  [PMID:10198209]
  Authors
Nagler DK, Sulea T, Menard R.
  Title
Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen.
  Journal
Biochem Biophys Res Commun 257:313-8 (1999)
DOI:10.1006/bbrc.1999.0461
  Sequence
[hsa:8722]
Reference
3  [PMID:10362521]
  Authors
Wex T, Levy B, Wex H, Bromme D.
  Title
Human cathepsins F and W: A new subgroup of cathepsins.
  Journal
Biochem Biophys Res Commun 259:401-7 (1999)
DOI:10.1006/bbrc.1999.0700
  Sequence
[hsa:8722]
Reference
4  [PMID:9822672]
  Authors
Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D.
  Title
Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization.
  Journal
J Biol Chem 273:32000-8 (1998)
DOI:10.1074/jbc.273.48.32000
  Sequence
[hsa:8722]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.41
IUBMB Enzyme Nomenclature: 3.4.22.41
ExPASy - ENZYME nomenclature database: 3.4.22.41
BRENDA, the Enzyme Database: 3.4.22.41
CAS: 65997-74-2

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