KEGG   ENZYME: 3.4.22.42Help
Entry
EC 3.4.22.42                Enzyme                                 

Name
cathepsin O
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec
Comment
Cathepsin O is a lysosomal cysteine peptidase of family C1 (papain family). The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32
History
EC 3.4.22.42 created 2000
Orthology
K01374  cathepsin O
Genes
HSA: 1519(CTSO)
PTR: 461567(CTSO)
PPS: 100983673(CTSO)
GGO: 101142847(CTSO)
PON: 100435624(CTSO)
NLE: 100584986(CTSO)
MCC: 699868(CTSO)
MCF: 102131405(CTSO)
CSAB: 103236433(CTSO)
RRO: 104658107(CTSO)
RBB: 108529021(CTSO)
CJC: 100388522(CTSO)
SBQ: 101030205(CTSO)
MMU: 229445(Ctso)
RNO: 684529(Ctso)
CGE: 100767833(Ctso)
NGI: 103751035(Ctso)
HGL: 101724540(Ctso)
CCAN: 109676099(Ctso)
OCU: 100349340(CTSO)
TUP: 102482353(CTSO)
CFA: 482665(CTSO)
AML: 100482864(CTSO)
UMR: 103658102(CTSO)
ORO: 101379477(CTSO)
FCA: 101090686(CTSO)
PTG: 102965401(CTSO)
AJU: 106982439(CTSO)
BTA: 616804(CTSO)
BOM: 102282130(CTSO)
BIU: 109571466(CTSO)
PHD: 102331870(CTSO)
CHX: 102168847(CTSO)
OAS: 101112852(CTSO)
SSC: 100737564(CTSO)
CFR: 102510489(CTSO)
CDK: 105101185(CTSO)
BACU: 103019962(CTSO)
LVE: 103076119(CTSO)
OOR: 101286592(CTSO)
ECB: 100069500(CTSO)
EPZ: 103566812(CTSO)
EAI: 106833025(CTSO)
MYB: 102249484(CTSO) 102254807
MYD: 102769744(CTSO)
HAI: 109376920(CTSO)
RSS: 109448192(CTSO)
PALE: 102878752(CTSO)
LAV: 100658992(CTSO)
TMU: 101344884
MDO: 100023827(CTSO)
SHR: 100928401(CTSO)
OAA: 100079864(CTSO)
GGA: 422410(CTSO)
MGP: 100547831(CTSO)
CJO: 107313050(CTSO)
APLA: 101789467(CTSO)
ACYG: 106032363(CTSO)
TGU: 100217754(CTSO) 100224161
GFR: 102035724(CTSO)
FAB: 101814200(CTSO)
PHI: 102100585(CTSO)
PMAJ: 107203397(CTSO)
CCAE: 111927852(CTSO)
CCW: 104697316(CTSO)
FPG: 101915196(CTSO)
FCH: 102048194(CTSO)
CLV: 102091575(CTSO)
EGZ: 104124153(CTSO)
AAM: 106492078(CTSO)
ASN: 102388157(CTSO)
AMJ: 102566412(CTSO)
PSS: 102452066(CTSO)
CMY: 102945758(CTSO)
CPIC: 101946599(CTSO)
ACS: 100562623(ctso)
PVT: 110072780(CTSO)
PBI: 103049265(CTSO)
GJA: 107110715
XLA: 108699249(ctso.L)
NPR: 108789642(CTSO)
DRE: 567333(ctso)
SANH: 107669075
IPU: 108269356(ctso)
AMEX: 103044819(ctso)
TRU: 101061735(ctso)
LCO: 104917914(ctso)
NCC: 104944574(ctso)
MZE: 101463838(ctso)
OLA: 101169673(ctso)
XMA: 102235560(ctso)
PRET: 103471833(ctso)
NFU: 107379734(ctso)
KMR: 108236687(ctso)
CSEM: 103390648(ctso)
LCF: 108885181(ctso)
SDU: 111232371(ctso)
HCQ: 109524480(ctso)
MALB: 109964273(ctso)
SASA: 100195562(ctso)
OTW: 112221053(ctso)
ELS: 105027627(ctso)
SFM: 108930809(ctso)
LCM: 102346436(CTSO)
CMK: 103187177(ctso)
SPU: 593754
APLC: 110977016
SKO: 100368679
AAG: 5577378
AME: 551290
BIM: 100746061
BTER: 100650715
SOC: 105195260
AEC: 105146944
ACEP: 105627124
PBAR: 105433323
HST: 105183495
DQU: 106744593
CFO: 105256710
LHU: 105680118
PGC: 109851729
PCF: 106791536
NVI: 100114880
MDL: 103571176
TCA: 659087
DPA: 109532781
NVL: 108567644
PMAC: 106719342
PRAP: 110993111
API: 100572803
DNX: 107166838
CLEC: 106667151
ZNE: 110832262
FCD: 110850889
CRG: 105335927
MYI: 110456678
OBI: 106881063
EPA: 110238472
ADF: 107342207
HMG: 100199722
 » show all
Taxonomy
Reference
1  [PMID:9790772]
  Authors
Santamaria I, Pendas AM, Velasco G, Lopez-Otin C.
  Title
Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO).
  Journal
Genomics 53:231-4 (1998)
DOI:10.1006/geno.1997.5180
  Sequence
[hsa:1519]
Reference
2  [PMID:7929457]
  Authors
Velasco G, Ferrando AA, Puente XS, Sanchez LM, Lopez-Otin C.
  Title
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.
  Journal
J Biol Chem 269:27136-42 (1994)
  Sequence
[hsa:1519]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.42
IUBMB Enzyme Nomenclature: 3.4.22.42
ExPASy - ENZYME nomenclature database: 3.4.22.42
BRENDA, the Enzyme Database: 3.4.22.42
CAS: 162032-86-2

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