KEGG   ENZYME: 3.4.22.43Help
Entry
EC 3.4.22.43                Enzyme                                 

Name
cathepsin V;
Cathepsin L2;
cathepsin U
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)
Comment
Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2
History
EC 3.4.22.43 created 2000
Orthology
K01375  cathepsin V
Genes
HSA: 1515(CTSV)
PTR: 107976728(CTSV)
PPS: 100974568(CTSV)
GGO: 101143768(CTSV)
PON: 100439744(CTSV)
NLE: 100586899(CTSV)
MCC: 710850(CTSV)
MCF: 102134104(CTSV)
CSAB: 103219808(CTSV)
RRO: 104659881(CTSV)
RBB: 108529277(CTSV)
CJC: 100411470(CTSV)
SBQ: 101031643(CTSV)
 » show all
Taxonomy
Reference
1  [PMID:10029531]
  Authors
Bromme D, Li Z, Barnes M, Mehler E.
  Title
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.
  Journal
Biochemistry 38:2377-85 (1999)
DOI:10.1021/bi982175f
  Sequence
[hsa:1515]
Reference
2  [PMID:9727401]
  Authors
Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K.
  Title
Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.
  Journal
Invest Ophthalmol Vis Sci 39:1789-96 (1998)
  Sequence
[hsa:1515]
Reference
3  [PMID:9563472]
  Authors
Santamaria I, Velasco G, Cazorla M, Fueyo A, Campo E, Lopez-Otin C.
  Title
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.
  Journal
Cancer Res 58:1624-30 (1998)
  Sequence
[hsa:1515]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.43
IUBMB Enzyme Nomenclature: 3.4.22.43
ExPASy - ENZYME nomenclature database: 3.4.22.43
BRENDA, the Enzyme Database: 3.4.22.43
CAS: 223670-00-6

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