KEGG   ENZYME: 3.4.22.52Help
Entry
EC 3.4.22.52                Enzyme                                 

Name
calpain-1;
mu-calpain;
calcium-activated neutral protease I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity
Comment
In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2.
History
EC 3.4.22.52 created 1981 as EC 3.4.22.17, transferred 2003 to EC 3.4.22.52
Orthology
K01367  calpain-1
Genes
HSA: 823(CAPN1)
PTR: 451317(CAPN1)
PPS: 100975624(CAPN1)
GGO: 101139860(CAPN1)
PON: 100174090(CAPN1)
NLE: 100605026(CAPN1)
MCC: 716618(CAPN1)
MCF: 101867512(CAPN1)
CSAB: 103230332(CAPN1)
RRO: 104662820(CAPN1)
RBB: 108543285(CAPN1)
CJC: 100411931(CAPN1)
SBQ: 101034774(CAPN1)
MMU: 12333(Capn1)
RNO: 29153(Capn1)
CGE: 100758636(Capn1)
NGI: 103724977(Capn1)
HGL: 101696511(Capn1)
CCAN: 109687155(Capn1)
OCU: 100009089(CAPN1)
TUP: 102482492(CAPN1)
CFA: 483745(CAPN1)
AML: 100468407(CAPN1)
UMR: 103679450(CAPN1)
ORO: 101386731(CAPN1)
FCA: 101096916(CAPN1)
PTG: 102955453(CAPN1)
AJU: 106971147(CAPN1)
BTA: 281661(CAPN1)
BOM: 102283099(CAPN1)
BIU: 109554508(CAPN1)
PHD: 102340536(CAPN1)
CHX: 100861313(CAPN1)
OAS: 443130(CAPN1)
SSC: 397027(CAPN1)
CFR: 102517688(CAPN1)
CDK: 105102612(CAPN1)
BACU: 103013016(CAPN1)
LVE: 103069107(CAPN1)
OOR: 101287191(CAPN1)
ECB: 100051106(CAPN1)
EPZ: 103559156(CAPN1)
EAI: 106833590(CAPN1)
MYB: 102249013(CAPN1)
MYD: 102770312(CAPN1)
HAI: 109384300(CAPN1)
RSS: 109450398(CAPN1)
PALE: 102891365(CAPN1)
LAV: 100658150(CAPN1)
TMU: 101341766
MDO: 100030405(CAPN1)
SHR: 100927376(CAPN1)
GGA: 396240(CAPN11) 693249(CAPN1)
MGP: 100549763(CAPN11)
CJO: 107307079(CAPN1) 107311285(CAPN11)
APLA: 101793085(calpain) 101794453(CAPN1)
ACYG: 106048204(CAPN11) 106049805(CAPN1)
TGU: 100225591 100232236(CAPN11)
GFR: 102035321(CAPN11) 102043510(CAPN1)
FAB: 101816358(CAPN11) 101818353
PHI: 102099356(CAPN11) 102102785(CAPN1)
PMAJ: 107202038(CAPN11)
CCAE: 111927556(CAPN11) 111943360
CCW: 104684409(CAPN11)
FPG: 101911941(CAPN1) 101913440(CAPN11)
FCH: 102045859(CAPN11) 102058565(CAPN1)
CLV: 102090692
EGZ: 104132723(CAPN11)
AAM: 106485511(CAPN11) 106494368(CAPN1)
ASN: 102368421(CAPN11) 102375021(CAPN1)
AMJ: 102557663(CAPN11) 102561469(CAPN1)
PSS: 102448184(CAPN11) 102458417(CAPN1)
CMY: 102940343(CAPN1)
CPIC: 101935497(CAPN1) 101953330(CAPN11)
PVT: 110070204(CAPN1) 110071084 110074688(CAPN11)
PBI: 103061442 103062813(CAPN1)
GJA: 107111051(CAPN1) 107115263(CAPN11)
XLA: 380177(capn1) 398288 398772 447208
XTR: 541454(capn1) 541455(capn1)
NPR: 108785269(CAPN1) 108802349
DRE: 393417(capn1a) 406768(zgc:55262) 553353(si:ch211-202f3.3) 565106(capn1b) 565825(si:dkeyp-50d11.2)
IPU: 108259403(CANX) 108267277(CAPN1) 108278958
LCO: 104918347(calpain-1) 104932304 104934901(capn11)
LCM: 102347136(CAPN1) 102363773(CAPN11)
CMK: 103177926(capn1)
 » show all
Taxonomy
Reference
1  [PMID:12014988]
  Authors
Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS.
  Title
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
  Journal
Biochem J 367:263-9 (2002)
DOI:10.1042/BJ20020485
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.52
IUBMB Enzyme Nomenclature: 3.4.22.52
ExPASy - ENZYME nomenclature database: 3.4.22.52
BRENDA, the Enzyme Database: 3.4.22.52
CAS: 78990-62-2

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