KEGG   ENZYME: 3.4.22.53Help
Entry
EC 3.4.22.53                Enzyme                                 

Name
calpain-2;
calcium-activated neutral protease II;
m-calpain;
milli-calpain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase specificity
Comment
Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1.
History
EC 3.4.22.53 created 1981 as EC 3.4.22.17, transferred 2003 to EC 3.4.22.53
Orthology
K03853  calpain-2
Genes
HSA: 824(CAPN2)
PTR: 457765(CAPN2)
PPS: 100988890(CAPN2)
GGO: 101149206(CAPN2)
PON: 100445754(CAPN2)
NLE: 100589114(CAPN2)
MCC: 703047(CAPN2)
MCF: 102122692(CAPN2)
CSAB: 103230023(CAPN2)
RRO: 104677285(CAPN2)
RBB: 108528248(CAPN2)
CJC: 100405215(CAPN2)
SBQ: 101035587(CAPN2)
MMU: 12334(Capn2)
RNO: 29154(Capn2)
CGE: 100771239(Capn2)
NGI: 103726266(Capn2)
HGL: 101720177(Capn2)
CCAN: 109677038(Capn2)
OCU: 100009092(CAPN2)
TUP: 102481316(CAPN2)
CFA: 480118(CAPN2)
AML: 100476150(CAPN2)
UMR: 103669131(CAPN2)
ORO: 101364547(CAPN2)
FCA: 101083231(CAPN2)
BTA: 281662(CAPN2)
BOM: 102276298(CAPN2)
BIU: 109570370(CAPN2)
PHD: 102319895(CAPN2)
CHX: 102181227(CAPN2)
OAS: 100127211(CAPN2)
SSC: 397393(CAPN2)
CFR: 102512386(CAPN2)
CDK: 105099835(CAPN2)
LVE: 103080579(CAPN2)
OOR: 101270285(CAPN2)
ECB: 100055184(CAPN2)
EPZ: 103563904(CAPN2)
EAI: 106829535(CAPN2)
MYB: 102240228(CAPN2)
MYD: 102769788(CAPN2)
HAI: 109381194(CAPN2)
RSS: 109437082
PALE: 102897695(CAPN2)
LAV: 100663804(CAPN2)
TMU: 101341399
MDO: 100018672(CAPN2)
SHR: 100922649
OAA: 100081577(CAPN2)
GGA: 395963(CAPN2)
MGP: 100546180(CAPN2)
CJO: 107311033(CAPN2)
APLA: 101799042(CAPN2)
ACYG: 106031621(CAPN2)
TGU: 100225408 100229579(CAPN2)
GFR: 102045030(CAPN2)
FAB: 101809391(CAPN2)
PHI: 102111446(CAPN2)
PMAJ: 107202529(CAPN2)
CCAE: 111926249(CAPN2)
CCW: 104685555(CAPN2)
FPG: 101919959(CAPN2)
FCH: 102048431(CAPN2)
CLV: 102084552
EGZ: 104124542(CAPN2)
AAM: 106482724(CAPN2)
ASN: 102373508(CAPN2)
AMJ: 102560432(CAPN2)
PSS: 102458713(CAPN2)
CMY: 102937008(CAPN2)
CPIC: 101940996(CAPN2)
ACS: 100561808(capn2)
PVT: 110075406(CAPN2)
PBI: 103056946
GJA: 107121636(CAPN2)
XLA: 100127267 108716477 108717697(capn2.2.S) 399075(capn2.2.L)
XTR: 448035(capn2.2)
NPR: 108786661 108787073(CAPN2)
DRE: 445091(zgc:92480) 541374(capn2a) 550505(capn2l) 563053(capn2b)
LCM: 102347065(CAPN2) 102347326
 » show all
Taxonomy
Reference
1  [PMID:10639123]
  Authors
Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W.
  Title
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
  Journal
Proc Natl Acad Sci U S A 97:588-92 (2000)
DOI:10.1073/pnas.97.2.588
  Sequence
[hsa:824]
Reference
2  [PMID:12014988]
  Authors
Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS.
  Title
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
  Journal
Biochem J 367:263-9 (2002)
DOI:10.1042/BJ20020485
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.53
IUBMB Enzyme Nomenclature: 3.4.22.53
ExPASy - ENZYME nomenclature database: 3.4.22.53
BRENDA, the Enzyme Database: 3.4.22.53
CAS: 702693-80-9

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