EC                Enzyme                                 

apoptotic protease Mch-2;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp!
Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC and caspase-7 (EC [2]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [2]. Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC and leads to the release of cytochrome c from the mitochondria. The release of cytochrome c is an essential component of the intrinsic apoptosis pathway [1]. The enzyme can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragmentation in the final phases of apoptosis [2,4,5,6]. Belongs in peptidase family C14.
EC created 2007
K04396  caspase 6
HSA: 839(CASP6)
PTR: 736606(CASP6)
PPS: 100973393(CASP6)
GGO: 101149243(CASP6)
PON: 100450330(CASP6)
NLE: 100591774(CASP6)
MCC: 698788(CASP6)
MCF: 101867077(CASP6)
CSAB: 103236104(CASP6)
RRO: 104671841(CASP6)
RBB: 108541015(CASP6)
CJC: 100394331(CASP6)
SBQ: 101046319(CASP6)
MMU: 12368(Casp6)
MCAL: 110291226(Casp6)
MPAH: 110320419(Casp6)
RNO: 83584(Casp6)
MUN: 110553242(Casp6)
CGE: 100766458(Casp6)
NGI: 103742454(Casp6)
HGL: 101707090(Casp6)
CCAN: 109694926(Casp6)
OCU: 100341546(CASP6)
TUP: 102481080(CASP6)
CFA: 487899(CASP6)
VVP: 112934219(CASP6)
AML: 100476854
UMR: 103661832(CASP6)
UAH: 113255556(CASP6)
ORO: 101375690(CASP6)
ELK: 111157298
FCA: 768261(PLA2G12A)
PTG: 102964120
PPAD: 109248009(PLA2G12A)
AJU: 106983648(PLA2G12A)
BTA: 538409(CASP6)
BOM: 102288095(CASP6)
BIU: 109560257(CASP6)
BBUB: 102389192(CASP6)
CHX: 102184605(CASP6)
OAS: 101119820 114108735(CASP6)
SSC: 100517293(CASP6)
CFR: 102521752(CASP6)
CDK: 105089897(CASP6)
BACU: 103001713(CASP6)
LVE: 103075936(CASP6)
OOR: 101275780 101285172(CASP6)
DLE: 111171500(CASP6)
PCAD: 102979663(CASP6) 102980899
ECB: 100072861(CASP6)
EPZ: 103562386(CASP6)
EAI: 106829803(CASP6)
MYB: 102253010(CASP6)
MYD: 102755758(CASP6)
MNA: 107534379(CASP6)
HAI: 109379418(CASP6)
DRO: 112296279(CASP6)
PALE: 102890010(CASP6)
RAY: 107508826(CASP6)
MJV: 108397533(CASP6)
LAV: 100668723(CASP6)
TMU: 101347761
MDO: 100009858(CASP6) 100019753
PCW: 110218614(CASP6)
OAA: 100074650(CASP6)
GGA: 395477(CASP6)
MGP: 100544078(CASP6)
CJO: 107313602(CASP6)
NMEL: 110398619(CASP6)
APLA: 101794069(CASP6)
ACYG: 106038643(CASP6)
TGU: 100232257(CASP6)
LSR: 110467998(CASP6)
SCAN: 103826003(CASP6)
GFR: 102034936(CASP6)
FAB: 101808850(CASP6)
PHI: 102111062(CASP6)
PMAJ: 107203274(CASP6)
CCAE: 111927775(CASP6)
CCW: 104697124(CASP6)
ETL: 114068460(CASP6)
FPG: 101917586(CASP6)
FCH: 102049956(CASP6)
CLV: 102092805(CASP6)
EGZ: 104135531(CASP6)
NNI: 104021161(CASP6)
ACUN: 113479592(CASP6)
PADL: 103919543(CASP6)
AAM: 106492034(CASP6)
ASN: 102387853(CASP6)
AMJ: 102572507(CASP6)
PSS: 102455131(CASP6)
CMY: 102945769(PLA2G12A)
CPIC: 101932940(CASP6)
ACS: 100564002(casp6)
PVT: 110087283(CASP6)
PBI: 103055774(CASP6)
PMUR: 107283297(CASP6)
TSR: 106537547(CASP6)
PMUA: 114603827(CASP6)
GJA: 107123241(CASP6)
XLA: 397818(casp6.L)
XTR: 496478(casp6)
NPR: 108798289(CASP6)
DRE: 552927(casp6a) 791531(casp6b.1)
EEE: 113570456(casp6) 113589890
TRU: 101075398(casp6)
LCO: 104927260(casp6)
NCC: 104941008(casp6)
OLA: 101157998 101164455(casp6)
XMA: 102225519(casp6)
XCO: 114145166(casp6)
PRET: 103472834(casp6)
CVG: 107094625(casp6)
NFU: 107375324(casp6)
KMR: 108230993
ALIM: 106517068(casp6)
AOCE: 111578659(casp6)
CSEM: 103383854(casp6)
POV: 109638322(casp6)
LCF: 108888249(casp6)
SDU: 111236608(casp6)
SLAL: 111671191(casp6)
HCQ: 109511079(casp6)
BPEC: 110165342(casp6)
MALB: 109955561(casp6)
SALP: 112074566(casp6)
ELS: 105020987(casp6)
SFM: 108936646(casp6) 108936647
PKI: 111852138(casp6)
LCM: 102356934(CASP6)
CMK: 103189377(casp6)
RTP: 109921991
BFO: 118417983
APLC: 110990159
SKO: 100368637
TCA: 100142180
DGT: 114529399
 » show all
1  [PMID:12232792]
Cowling V, Downward J.
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain.
Cell Death Differ 9:1046-56 (2002)
2  [PMID:11104820]
Chang HY, Yang X.
Proteases for cell suicide: functions and regulation of caspases.
Microbiol Mol Biol Rev 64:821-46 (2000)
3  [PMID:12049625]
Kang BH, Ko E, Kwon OK, Choi KY.
The structure of procaspase 6 is similar to that of active mature caspase 6.
Biochem J 364:629-34 (2002)
4  [PMID:16518869]
Lee SC, Chan J, Clement MV, Pervaiz S.
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
Proteomics 6:2386-94 (2006)
5  [PMID:12089322]
MacLachlan TK, El-Deiry WS.
Apoptotic threshold is lowered by p53 transactivation of caspase-6.
Proc Natl Acad Sci U S A 99:9492-7 (2002)
6  [PMID:8710882]
Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC.
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
Proc Natl Acad Sci U S A 93:8395-400 (1996)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 182372-15-2

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