KEGG   ENZYME: 3.4.22.60Help
Entry
EC 3.4.22.60                Enzyme                                 

Name
caspase-7;
CASP-7;
ICE-like apoptotic protease 3;
ICE-LAP3;
apoptotic protease Mch-3;
Mch3;
CMH-1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp!
Comment
Caspase-7 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-6 (EC 3.4.22.59) [1]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [2]. Although a hydrophobic residue at P5 of caspase-2 (EC 3.4.22.55) and caspase-3 leads to more efficient hydrolysis, the amino-acid residue at this location in caspase-7 has no effect [3]. Caspase-7 is activated by the initiator caspases [caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63)]. Removal of the N-terminal prodomain occurs before cleavage in the linker region between the large and small subunits [4]. Belongs in peptidase family C14.
History
EC 3.4.22.60 created 2007
Orthology
K04397  caspase 7
Genes
HSA: 840(CASP7)
PTR: 450745(CASP7)
PPS: 100985952(CASP7)
GGO: 101147760(CASP7)
PON: 100435918(CASP7)
NLE: 100591910(CASP7)
MCC: 697633(CASP7)
MCF: 102127213(CASP7)
CSAB: 103216537(CASP7)
RRO: 104662231(CASP7)
RBB: 108542466(CASP7)
CJC: 100386577(CASP7)
SBQ: 101036039(CASP7)
MMU: 12369(Casp7)
RNO: 64026(Casp7)
CGE: 100766857(Casp7)
NGI: 103731752(Casp7)
HGL: 101709568(Casp7)
CCAN: 109688558(Casp7)
OCU: 100101591(CASP7)
TUP: 102470949(CASP7)
CFA: 486896(CASP7)
AML: 100471992(CASP7)
UMR: 103657312(CASP7)
ORO: 101363955(CASP7)
FCA: 768262(CASP7)
PTG: 102951959(CASP7)
AJU: 106974123(CASP7)
BTA: 526279(CASP7)
BOM: 102271384(CASP7)
BIU: 109553157(CASP7)
PHD: 102324332(CASP7)
CHX: 100861343(CASP7)
OAS: 101122741(CASP7)
SSC: 100156777(CASP7)
CFR: 102509752(CASP7)
CDK: 105091687(CASP7)
BACU: 103013605(CASP7)
LVE: 103083104(CASP7)
OOR: 101287199(CASP7)
ECB: 100068258(CASP7)
EPZ: 103540204(CASP7)
EAI: 106848104(CASP7)
MYB: 102243767(CASP7)
MYD: 102768516(CASP7)
HAI: 109384919(CASP7)
RSS: 109444081(CASP7)
PALE: 102879606(CASP7)
LAV: 100670890(CASP7)
TMU: 101346298
MDO: 100027500(CASP7)
SHR: 100927801(CASP7)
OAA: 100082745(CASP7)
GGA: 423901(CASP7)
MGP: 100546410(CASP7)
CJO: 107316128(CASP7)
APLA: 101799962(CASP7) 101800944
ACYG: 106031898(CASP7) 106048888
TGU: 100218002(CASP7) 100218205
GFR: 102032484(CASP7)
FAB: 101807080(CASP7)
PHI: 102112480(CASP7)
PMAJ: 107207062(CASP7)
CCAE: 111931322(CASP7)
CCW: 104695187(CASP7)
FPG: 101911113(CASP7)
FCH: 102047023(CASP7)
CLV: 102084230(CASP7)
EGZ: 104123620(CASP7)
AAM: 106483734(CASP7)
ASN: 102375360(CASP7)
AMJ: 102566884(CASP7)
PSS: 102455743 102458724(CASP7)
CMY: 102931635(Caspase-3) 102934687(CASP7)
CPIC: 101936900(CASP7) 101949026
ACS: 100563813(casp7)
PVT: 110071974(CASP7) 110084328
PBI: 103054928(CASP7) 103066503
XLA: 100037079(casp7.S) 108711587 108712725 397819(xcaspase-7)
XTR: 549053(casp7) 733553
NPR: 108792468 108793513(CASP7)
DRE: 553634(casp7) 798445
IPU: 108273727(casp7)
AMEX: 103041716(casp7)
TRU: 101068895(casp7) 101074856
LCO: 104927890(casp7) 104937898
NCC: 104942136(casp7)
OLA: 101156378 101161677(casp7)
XMA: 102230553(casp7)
PRET: 103481281(casp7)
NFU: 107387877(casp7)
KMR: 108242539 108246368(casp7)
CSEM: 103381449(casp7) 103389354
SDU: 111219886(casp7) 111224299
HCQ: 109523912
BPEC: 110154157(casp7) 110161916
MALB: 109951188 109963005(casp7)
SASA: 106568012 106578356(casp7)
ELS: 105015185 105026234(casp7)
SFM: 108923620 108940466(casp7)
LCM: 102357990(CASP7) 102367521
CMK: 103172118(caspase-7) 103172119 103186582(casp7)
CIN: 100178691
DME: Dmel_CG14902(Decay) Dmel_CG7788(Drice)
DSI: Dsimw501_GD20281(Dsim_GD20281) Dsimw501_GD21467(Dsim_GD21467)
MDE: 101889252(caspase-1) 101896713
AGA: AgaP_AGAP000830(CASPS7) AgaP_AGAP004920(CASPS6) AgaP_AGAP004921(CASPS5) AgaP_AGAP004922(CASPS11) AgaP_AGAP011951(CASPS4)
AME: 412235
BMOR: 100134925 100862780(Casp-4) 692604(Caspase1) 692735(ICE)
PMAC: 106718543
PXY: 105385382 105394672(caspase-1)
SHX: MS3_08153
EGL: EGR_05059
EPA: 110236584
HMG: 100210729
AQU: 105314888
CCAV: 112505388
 » show all
Taxonomy
Reference
1  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
Reference
2
  Authors
Nicholson, D. and Thornberry, N.A.
  Title
Caspase-3 and caspase-7.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, 2nd ed., Elsevier, London, 2004, p. 1298-1302.
Reference
3  [PMID:16781734]
  Authors
Fang B, Boross PI, Tozser J, Weber IT.
  Title
Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition.
  Journal
J Mol Biol 360:654-66 (2006)
DOI:10.1016/j.jmb.2006.05.041
Reference
4  [PMID:12824163]
  Authors
Denault JB, Salvesen GS.
  Title
Human caspase-7 activity and regulation by its N-terminal peptide.
  Journal
J Biol Chem 278:34042-50 (2003)
DOI:10.1074/jbc.M305110200
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.60
IUBMB Enzyme Nomenclature: 3.4.22.60
ExPASy - ENZYME nomenclature database: 3.4.22.60
BRENDA, the Enzyme Database: 3.4.22.60
CAS: 189258-14-8

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