KEGG   ENZYME: 3.4.22.64Help
Entry
EC 3.4.22.64                Enzyme                                 

Name
caspase-11;
CASP-11
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp!
Comment
This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide [1]. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions [1,2]. Belongs in peptidase family C14.
History
EC 3.4.22.64 created 2007
Orthology
K04394  caspase 4
Genes
HSA: 837(CASP4)
PTR: 451518(CASP4)
PPS: 100991353(CASP4)
GGO: 101139012(CASP4) 101139367
PON: 100436933
NLE: 100587427(CASP4)
MCC: 704864(CASP4)
MCF: 102116921(CASP4)
CSAB: 103248367(CASP4)
RRO: 104665269
RBB: 108513171
CJC: 100385257(CASP4)
SBQ: 101048389
MMU: 12363(Casp4)
RNO: 114555(Casp4)
NGI: 103743234(Casp4)
HGL: 101700797(Casp4)
CCAN: 109694936
OCU: 100358658 100359184(CASP4)
TUP: 102468460 102489894(CASP4)
CFA: 403724(CASP4)
AML: 100464921(CASP4)
UMR: 103662442
ORO: 101382016
FCA: 493961(CASP4)
PTG: 102967742
AJU: 106976501
BTA: 338039(CASP4)
BOM: 102272500(CASP1)
BIU: 109569831
PHD: 102340851
CHX: 102191717(CASP1)
OAS: 101117272
SSC: 100522887
CDK: 105100419
BACU: 103012084
LVE: 103078575
OOR: 101290090
ECB: 100069303(CASP4) 100069322
MYD: 102769995
LAV: 100661933
MDO: 100032600
 » show all
Taxonomy
Reference
1  [PMID:10791975]
  Authors
Kang SJ, Wang S, Hara H, Peterson EP, Namura S, Amin-Hanjani S, Huang Z, Srinivasan A, Tomaselli KJ, Thornberry NA, Moskowitz MA, Yuan J.
  Title
Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.
  Journal
J Cell Biol 149:613-22 (2000)
Reference
2  [PMID:11684090]
  Authors
Hur J, Kim SY, Kim H, Cha S, Lee MS, Suk K.
  Title
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway.
  Journal
FEBS Lett 507:157-62 (2001)
DOI:10.1016/S0014-5793(01)02975-1
  Sequence
[rno:114555]
Reference
3  [PMID:9491891]
  Authors
Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J.
  Title
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.
  Journal
Cell 92:501-9 (1998)
DOI:10.1016/S0092-8674(00)80943-5
  Sequence
[mmu:12363]
Reference
4  [PMID:16670335]
  Authors
Endo M, Mori M, Akira S, Gotoh T.
  Title
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.
  Journal
J Immunol 176:6245-53 (2006)
DOI:10.4049/jimmunol.176.10.6245
  Sequence
[mmu:12363]
Reference
5  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.64
IUBMB Enzyme Nomenclature: 3.4.22.64
ExPASy - ENZYME nomenclature database: 3.4.22.64
BRENDA, the Enzyme Database: 3.4.22.64

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