KEGG   ENZYME: 3.4.22.70Help
Entry
EC 3.4.22.70                Enzyme                                 

Name
sortase A;
SrtA;
SrtA protein;
SrtA sortase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.
Comment
In peptidase family C60.
History
EC 3.4.22.70 created 2009
Orthology
K07284  sortase A
Genes
SON: SO_2196(srtA)
SFR: Sfri_1626
SAZ: Sama_2002
SBL: Sbal_1844
SBM: Shew185_1830
SBN: Sbal195_1878
SBP: Sbal223_2447
SBT: Sbal678_1917
SBS: Sbal117_1962
SBB: Sbal175_2509
SLO: Shew_1794
SSE: Ssed_2491
SPL: Spea_2515
SHL: Shal_1737
SWD: Swoo_2125
SWP: swp_3091
SVO: SVI_1841
CPS: CPS_3380
PHA: PSHAa0631
PAT: Patl_3923
PSEO: OM33_05920
PSPO: PSPO_a0600(srtA)
PTU: PTUN_a3420(srtA)
MAQ: Maqu_3683
MHC: MARHY3592
MAD: HP15_3445
AMAC: MASE_13650
GNI: GNIT_0711(srtA)
GPS: C427_0550 C427_0551(srtA)
SDE: Sde_0123
SAGA: M5M_19010
TIG: THII_2405
HCH: HCH_00090
ADI: B5T_00100
AXE: P40_00505
KKO: Kkor_2416
KGE: TQ33_0146
TBN: TBH_C1252
DSF: UWK_00696
PLA: Plav_2294
RLE: RL3445
RLG: Rleg_2999
OAN: Oant_4847
OAH: DR92_3728
BJA: bll0976
BRA: BRADO6888
BBT: BBta_0663
BRS: S23_68310
AOL: S58_05880
BRAD: BF49_7211
MEX: Mext_1399
MDI: METDI2057
MCH: Mchl_1674
MPO: Mpop_1394
MET: M446_5133
MOR: MOC_5872
META: Y590_06480
RBM: TEF_17890
MAGQ: MGMAQ_3206
BSU: BSU09200(yhcS) BSU36340(ywpE)
BSH: BSU6051_09200(yhcS) BSU6051_36340(ywpE)
BSUT: BSUB_01015(yhcS) BSUB_03868(ywpE)
BSUL: BSUA_01015(yhcS) BSUA_03868(ywpE)
BSO: BSNT_07352(yhcS) BSNT_10283(ywpE)
BSQ: B657_09200(srtA) B657_36340(ywpE)
BSX: C663_0943(yhcS)
BLI: BL00120(ywpE) BL03172(yhcS)
BLD: BLi00602 BLi00983(yhcS)
BAY: RBAM_009460(yhcS)
BAQ: BACAU_0749(srtA) BACAU_0906(yhcS)
BYA: BANAU_0694(srtA) BANAU_0851(yhcS)
BAML: BAM5036_0848(srtA)
BAMA: RBAU_0909(srtA)
BAMN: BASU_0885(srtA)
BAMB: BAPNAU_0705(srtA) BAPNAU_2856(yhcS)
BAMY: V529_07160(srtA) V529_08810
BAO: BAMF_0725(ywpE) BAMF_1016(yhcS)
BAZ: BAMTA208_03430(ywpE) BAMTA208_04290(yhcS)
BQL: LL3_00779(ywpE) LL3_01001(yhcS)
BQY: MUS_0770(ywpE) MUS_0957(yhcS)
BAMC: U471_09280
BWW: bwei_0069 bwei_3288(srtA3) bwei_4908(srtA2) bwei_5790(srtA)
BCL: ABC3565
BMQ: BMQ_3150
BMD: BMD_3175
BMEG: BG04_81
BACP: SB24_05150
BACO: OXB_1111
OIH: OB0332
GKA: GK2003
AFL: Aflv_2645
AAMY: GFC30_434
AXL: AXY_19090
LSP: Bsph_0953(srtA)
SAU: SA2316(srtA)
SAV: SAV2528(srtA)
SAW: SAHV_2512(srtA)
SAM: MW2448(srtA)
SAS: SAS2414
SAR: SAR2608(srtA)
SAC: SACOL2539(srtA)
SAX: USA300HOU_2517(srtA)
SAA: SAUSA300_2467(srtA)
SAE: NWMN_2426(srtA)
SAD: SAAV_2593(srtA)
SUJ: SAA6159_02424(srtA)
SUK: SAA6008_02566(srtA)
SUZ: MS7_2534(srtA)
SUX: SAEMRSA15_24270(srtA)
SUW: SATW20_26490(srtA)
SUG: SAPIG2578
SUF: SARLGA251_23030(srtA)
SAUA: SAAG_00349
SAUE: RSAU_002369(srtA)
SAUS: SA40_2281(srtA)
SAUU: SA957_2365(srtA)
SAUG: SA268_2442(srtA)
SAUZ: SAZ172_2626(srtA)
SAUT: SAI1T1_2018830(srtA)
SAUJ: SAI2T2_1018840(srtA)
SAUK: SAI3T3_1018830(srtA)
SAUQ: SAI4T8_1018840(srtA)
SAUV: SAI7S6_1018830(srtA)
SAUW: SAI5S5_1018770(srtA)
SAUX: SAI6T6_1018770(srtA)
SAUY: SAI8T7_1018810(srtA)
SAUF: X998_2511
SAB: SAB2402c(srtA)
SUY: SA2981_2464(srtA)
SAUB: C248_2585(srtA)
SAUC: CA347_2602
SAUR: SABB_01155(srtA)
SAUI: AZ30_13250
SAUD: CH52_06360
SAMS: NI36_12630
SER: SERP2089(srtA)
SEPP: SEB_02082
SEPS: DP17_1025
SHA: SH0543(srtA)
SHH: ShL2_00438(srtA)
SSP: SSP0371
SCA: SCA_2003(srtA)
SLN: SLUG_04700(srtA)
SDT: SPSE_0356(srtA)
SPAS: STP1_1019
SXO: SXYL_00402(srtA)
SHU: SHYC_02315(srtA)
SSCH: LH95_02050
SSCZ: RN70_02360
SAGQ: EP23_07820
LMO: lmo0929
LMOC: LMOSLCC5850_0931(srtA)
LMOE: BN418_1128
LMOB: BN419_1131
LMOD: LMON_0935
LMOW: AX10_13205
LMOM: IJ09_05655
LMC: Lm4b_00948(srtA)
LMOG: BN389_09590(ywpE)
LMP: MUO_04920
LMOL: LMOL312_0930(srtA)
LMOX: AX24_02020
LMQ: LMM7_0965(srtA)
LML: lmo4a_0944(srtA)
LMS: LMLG_1417
LMW: LMOSLCC2755_0929(srtA)
LMX: LMOSLCC2372_0942(srtA)
LMZ: LMOSLCC2482_0974(srtA)
LMON: LMOSLCC2376_0899(srtA)
LMOS: LMOSLCC7179_0909(srtA)
LMOO: LMOSLCC2378_0946(srtA)
LMOY: LMOSLCC2479_0941(srtA)
LMOT: LMOSLCC2540_0928(srtA)
LMOA: LMOATCC19117_0951(srtA)
LMOK: CQ02_04860
LIN: lin0929
LWE: lwe0907(srtA)
LSG: lse_0827(srtA)
ESI: Exig_0466
EAN: Eab7_0442(srtA)
PPM: PPSC2_02235(srtA)
PPO: PPM_0402(srtA)
PPOL: X809_01815
PPQ: PPSQR21_004070(srtA)
PPOY: RE92_09695
PSAB: PSAB_02980
PSWU: SY83_05140
AAC: Aaci_0149
AAD: TC41_0190(srtA)
BTS: Btus_1032
JEO: JMA_37570
KUR: ASO14_346
LLA: L125196(ylcC) L169709(yhhA)
LLK: LLKF_0779(srtC) LLKF_1140(srtA) LLKF_1396(srtB)
LLT: CVCAS_0722(srtC) CVCAS_1086(srtA)
LLS: lilo_0690(yhhA) lilo_1016(ylcC)
LLX: NCDO2118_0775(srtC) NCDO2118_1116(srtA) NCDO2118_1359(srtB)
LLM: llmg_1449(srtA) llmg_1801(srtC)
LLI: uc509_1118(srtA)
LLJ: LG36_0744(srtC) LG36_1265(srtA)
LGR: LCGT_1291
LGV: LCGL_1312
LPK: LACPI_0534(srtA1) LACPI_0535(srtC) LACPI_1344(srtA2)
SPYA: A20_0163(srtC) A20_0913
SPS: SPs1010
SPF: SpyM50915(srtA)
STG: MGAS15252_0143(srtC) MGAS15252_0875(srtA)
STX: MGAS1882_0143(srtC) MGAS1882_0870(srtA)
SPYH: L897_04370
SPD: SPD_1076(srtA)
SPR: spr1098(srtA)
SPW: SPCG_1083
SJJ: SPJ_1133
SNV: SPNINV200_10160(srtA)
SPX: SPG_1110
SND: MYY_1021
SPNN: T308_04685
SNE: SPN23F11150(srtA)
SPV: SPH_1333
SPP: SPP_1256
SNI: INV104_10460(srtA)
SNP: SPAP_1244
SNX: SPNOXC10890(srtA)
SNU: SPNA45_00970(srtA)
SPNE: SPN034156_01770(srtA)
SPNU: SPN034183_10890(srtA)
SPNM: SPN994038_10780(srtA)
SPNO: SPN994039_10790(srtA)
SAG: SAG0647 SAG0648 SAG0961(srtA)
SGC: A964_0939(srtA) A964_1320
SAGP: V193_04450
SAGC: DN94_04450
SAGN: W903_1028
SMU: SMU_1113(srtA)
SMC: SmuNN2025_0928(srtA)
SMJ: SMULJ23_0926(srtA)
SMUA: SMUFR_0971(srtA)
STC: str1277
STL: stu1277
STE: STER_1255
STN: STND_1228
STW: Y1U_C1195
STHE: T303_07335
SSA: SSA_1219(srtA) SSA_1631(srtC)
SSB: SSUBM407_0856(srtA)
SSI: SSU0428 SSU0453(srtE) SSU0925(srtA)
SSS: SSUSC84_0968(srtA)
SSQ: SSUD9_0495(srtC1) SSUD9_0525 SSUD9_1248(srtA)
SSUT: TL13_0526(strA) TL13_0872(srtA)
SGO: SGO_1230(srtA)
SEZ: Sez_0813(srtC.1) Sez_1020(srtA) Sez_1820(srtC.2) Sez_1826(srtC.3) Sez_1827(srtC.4)
SEZO: SeseC_01090(srtA) SeseC_01347(srtA) SeseC_02470(srtA) SeseC_02471(srtC)
SUB: SUB0881(srtA)
SDA: GGS_0156(srtC.4) GGS_0157(srtC.3) GGS_0159(srtC.4) GGS_0160(srtC.3) GGS_0889(srtA)
SGT: SGGB_0178(srtA1) SGGB_1117(srtA2) SGGB_1566(srtC1) SGGB_1666(srtA3) SGGB_2020(srtC2) SGGB_2153(srtA4) SGGB_2209(srtC3)
SMB: smi_1008(srtA)
SOR: SOR_0847(srtA)
STK: STP_0694(srtA)
STB: SGPB_0986(srtA) SGPB_1845(srtC)
SCF: Spaf_0978(srtA)
STF: Ssal_00905(srtA)
SIB: SIR_0082 SIR_0494(srtC) SIR_0811(srtA)
SIU: SII_0084 SII_0825(srtA)
SANG: SAIN_0973(srtA)
SANC: SANR_1049(srtA)
SCG: SCI_0960(srtA)
SCON: SCRE_0888(srtA)
SCOS: SCR2_0888(srtA)
SIK: K710_1067
STRN: SNAG_0872
LPL: lp_0514(srtA)
LPJ: JDM1_0416(srtA)
LPT: zj316_0658(srtA)
LPS: LPST_C0418(srtA)
LJO: LJ_1476
LJF: FI9785_791(srtA)
LJH: LJP_0753
LAC: LBA1244(srtA)
LAD: LA14_1249
LAF: SD55_1240(srtA)
LSA: LCA_0066(srtA1) LCA_1591(srtA2)
LSL: LSL_1606
LSI: HN6_01350
LSJ: LSJ_1662c
LDB: Ldb1310(srtA)
LBU: LBUL_1224
LBR: LVIS_0496
LCB: LCABL_05230(srt2) LCABL_06160(srtA) LCABL_23200(srtA) LCABL_25390(srt2)
LGA: LGAS_0825
LRE: Lreu_0236
LRF: LAR_0227
LRT: LRI_1722
LHE: lhv_1331
LHL: LBHH_0828
LHV: lhe_1261
LHH: LBH_1093
LHD: HUO_05455
LFE: LAF_0205
LFF: LBFF_0225
LRH: LGG_00441(srtC1) LGG_02143(srtA) LGG_02369(srtC2)
LRL: LC705_02150(srtA) LC705_02366(srtC2) LC705_p00020(srtA2)
LCR: LCRIS_01262(srtA)
LAM: LA2_07055
LBH: Lbuc_1581
LBN: LBUCD034_1639(srtA)
LRM: LRC_00630 LRC_16570(srtA)
LSN: LSA_05550
LAE: LBAT_1597
PPE: PEPE_1566
PPEN: T256_07730
EFL: EF62_0133(srtA) EF62_1545(srtC)
EFN: DENG_01230(srtA) DENG_02942(srtA)
MPS: MPTP_0053
MPX: MPD5_0048
OOE: OEOE_1443
LME: LEUM_0714
LMM: MI1_03260
WKO: WKK_02830
WCE: WS08_0848
WCT: WS74_0914
CRN: CAR_c15170(ywpE)
CML: BN424_1760 BN424_2317(srtA) BN424_2789(srtA) BN424_3144(srtB) BN424_577(srtA)
CARC: NY10_835
CAC: CA_C0204(srta)
CAE: SMB_G0209(srta)
CAY: CEA_G0209(srta)
CTC: CTC_01198
CBO: CBO2133
CBA: CLB_2071
CBH: CLC_2076
CBY: CLM_2344
CBL: CLK_1590
CBB: CLD_2505
CBI: CLJ_B2340
CBF: CLI_2179
CBM: CBF_2163
CBV: U729_908
CSD: Clst_1279
CCEL: CCDG5_1265
RUS: RBI_I01263(yhcS) RBI_II00161(srtA)
FPR: FP2_31410
RIM: ROI_29700
BPRL: CL2_26920
STH: STH2376
SLP: Slip_1253
DHD: Dhaf_4302
OVA: OBV_14280
SAY: TPY_1935 TPY_1993(srtA)
ERH: ERH_0013
EBM: SG0102_01150(srtC2) SG0102_04670(srtC)
CGL: NCgl2838(Cgl2939)
CEF: CE2738
CDP: CD241_0188(srtB) CD241_0190(srtC) CD241_1907(srtA) CD241_2114(srtE) CD241_2115(srtD)
CDH: CDB402_0154(srtB) CDB402_0156(srtC) CDB402_0200(srtD) CDB402_0201(srtE)
CDT: CDHC01_0190(srtB) CDHC01_0192(srtC) CDHC01_1909(srtA) CDHC01_2114(srtE) CDHC01_2115(srtD)
CDE: CDHC02_0191(srtB) CDHC02_0193(srtC) CDHC02_0238(srtD) CDHC02_0239(srtE) CDHC02_1898(srtA)
CDR: CDHC03_0157(srtC) CDHC03_0159(srtB) CDHC03_1886(srtA) CDHC03_2107(srtE) CDHC03_2108(srtH)
CDA: CDHC04_0146(srtB) CDHC04_0148(srtC) CDHC04_1885(srtA1) CDHC04_1925(srtA2) CDHC04_2135(srtE) CDHC04_2136(srtD)
CDZ: CD31A_0226(srtB) CD31A_0229(srtC) CD31A_0277(srtH) CD31A_0278(srtI)
CDB: CDBH8_0186(srtB) CDBH8_0188(srtC) CDBH8_1978(srtA)
CDS: CDC7B_0184(srtB) CDC7B_0186(srtC) CDC7B_0230(srtH) CDC7B_0231(srtI)
CDD: CDCE8392_0189(srtB) CDCE8392_0192(srtC) CDCE8392_1894(srtA)
CDW: CDPW8_0231(srtC1) CDPW8_1977(srtA3)
CDV: CDVA01_0139(srtB) CDVA01_0141(srtC) CDVA01_1843(srtA) CDVA01_2031(srtE) CDVA01_2032(srtD)
CJK: jk1700(srtA)
CUR: cu1897(srtB) cu1899(srtC)
CUA: CU7111_1828(srtB) CU7111_1830(srtC)
CAR: cauri_0189(srtD) cauri_0190(srtE)
CPU: cpfrc_01873(srtA) cpfrc_01875(srtB) cpfrc_01905(srtC)
CPL: Cp3995_1923(srtB) Cp3995_1926(srtA) Cp3995_1954(srtA)
CPG: Cp316_1929(srtB) Cp316_1957(srtA)
CPP: CpP54B96_1902(srtB) CpP54B96_1906(srtA) CpP54B96_1933(srtA)
CPK: Cp1002_1870(srtB) Cp1002_1874(srtA) Cp1002_1901(srtA)
CPQ: CpC231_1864(srtB) CpC231_1867(srtA) CpC231_1893(srtA)
CPX: CpI19_1881(srtB2) CpI19_1884(srtA2) CpI19_1914(srtA1)
CPZ: CpPAT10_1875(srtB) CpPAT10_1877(srtA) CpPAT10_1906(srtA)
COR: Cp267_1942(srtB) Cp267_1946(srtA) Cp267_1974(srtA)
COP: Cp31_1862(srtB1) Cp31_1864(srtA1) Cp31_1893(srtA2)
COD: Cp106_1830(srtB) Cp106_1857(srtA)
COS: Cp4202_1862(srtB) Cp4202_1866(srtA) Cp4202_1894(srtA)
COI: CpCIP5297_1891(srtB1) CpCIP5297_1928(srtA2) CpCIP5297_2274(srtA)
COE: Cp258_1886(srtB) Cp258_1888(srtA) Cp258_1918(srtA)
COU: Cp162_1847(srtB1) Cp162_1849(srtA1) Cp162_1878(srtA2)
CRD: CRES_0406(srtA) CRES_0409(srtB)
CUL: CULC22_02105(srtC) CULC22_02107(srtB) CULC22_02132(srtA)
CUC: CULC809_01951(srtC) CULC809_01953(srtB) CULC809_01981(srtA)
CUN: Cul210932_2079(srtB1) Cul210932_2083(srtA1) Cul210932_2112(srtA2)
CUS: CulFRC11_1968(srtB) CulFRC11_1970(srtA1) CulFRC11_1999(srtA2)
CUQ: Cul210931_2023(srtB1) Cul210931_2025(srtA1) Cul210931_2053(srtA2)
CUZ: Cul05146_2066(srtB1) Cul05146_2068(srtA1) Cul05146_2097(srtA2)
CKU: UL82_00220(srtE) UL82_08835(srtA) UL82_09760(srtD)
CCJ: UL81_00625(srtA) UL81_08785(srtB)
CEI: CEPID_10435(srtB) CEPID_10450(srtA)
SCO: SCO3850(SCH69.20c)
SALB: XNR_3035
SALS: SLNWT_3587
SLE: sle_35740(sle_35740)
STRD: NI25_19065
SALJ: SMD11_3459(srtA) SMD11_3462(srtA)
TWH: TWT_564
TWS: TW197
LXX: Lxx00190
CMI: CMM_0013
CMS: CMS0014(srtA)
CMC: CMN_00013
ART: Arth_0017
ACH: Achl_0017
BCV: Bcav_0035
JDE: Jden_0283
XCE: Xcel_1522
IDO: I598_2491
CFI: Celf_0026
SERJ: SGUI_2616
PFR: PFREUD_19210(srtA) PFREUD_19740(srt)
KFL: Kfla_2014
PSIM: KR76_19920
TFU: Tfu_2383
NDA: Ndas_0374
NAL: B005_3241
TCU: Tcur_0060
FAL: FRAAL2033
ACE: Acel_0016
GOB: Gobs_0134
MMAR: MODMU_0327
AMD: AMED_7360(srtA)
AMN: RAM_37835
AMM: AMES_7249(srtA)
AMZ: B737_7249(srtA)
AOI: AORI_1802(srtA)
AJA: AJAP_30485(srtA)
AFS: AFR_00310
SNA: Snas_6133
AHE: Arch_0229
BLJ: BLD_1287(srtA1) BLD_1469(srtA4)
BLN: Blon_0162
BLON: BLIJ_0166
BLL: BLJ_0146
BLB: BBMN68_1231(srtA1) BBMN68_1406(srtA4) BBMN68_437
BLV: BalV_1306(srtB) BalV_1440
BBF: BBB_0267(srtA) BBB_0814 BBB_1709(srtA) BBB_1818(srtA)
BAST: BAST_0371
SIJ: SCIP_0159
RXY: Rxyl_2899
APV: Apar_1261
OLS: Olsu_0293
CAU: Caur_0431
CAG: Cagg_3111
HAU: Haur_4642
STI: Sthe_2655
ATM: ANT_23120
NDE: NIDE0940
NJA: NSJP_1967
MTH: MTH_1829
METC: MTCT_1669
METE: tca_01767
METH: MBMB1_1336
MCUB: MCBB_1576
MFV: Mfer_0746
MKA: MK0158(srtA)
 » show all
Taxonomy
Reference
1  [PMID:10535938]
  Authors
Ton-That H, Liu G, Mazmanian SK, Faull KF, Schneewind O
  Title
Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif.
  Journal
Proc Natl Acad Sci U S A 96:12424-9 (1999)
DOI:10.1073/pnas.96.22.12424
Reference
2  [PMID:15117963]
  Authors
Zong Y, Bice TW, Ton-That H, Schneewind O, Narayana SV
  Title
Crystal structures of Staphylococcus aureus sortase A and its substrate complex.
  Journal
J Biol Chem 279:31383-9 (2004)
DOI:10.1074/jbc.M401374200
  Sequence
Reference
3  [PMID:19129180]
  Authors
Race PR, Bentley ML, Melvin JA, Crow A, Hughes RK, Smith WD, Sessions RB, Kehoe MA, McCafferty DG, Banfield MJ
  Title
Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.
  Journal
J Biol Chem 284:6924-33 (2009)
DOI:10.1074/jbc.M805406200
  Sequence
[spy:SPy_1154]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.70
IUBMB Enzyme Nomenclature: 3.4.22.70
ExPASy - ENZYME nomenclature database: 3.4.22.70
BRENDA, the Enzyme Database: 3.4.22.70

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