KEGG   ENZYME: 3.4.22.71Help
Entry
EC 3.4.22.71                Enzyme                                 

Name
sortase B;
SrtB
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme catalyses a cell wall sorting reaction in which a surface protein with a sorting signal containing a NPXTN motif is cleaved between the Thr and Asn residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.
Comment
In peptidase family C60.
History
EC 3.4.22.71 created 2009
Orthology
K08600  sortase B
Genes
BHA: BH3294
BAN: BA_4783(srtB)
BAR: GBAA_4783
BAT: BAS4438
BAH: BAMEG_4815(srtB)
BAI: BAA_4796(srtB)
BAX: H9401_4565
BANT: A16_47740
BANR: A16R_48420
BANS: BAPAT_4589
BANV: DJ46_3452(srtB)
BCE: BC4543
BCA: BCE_4667
BCR: BCAH187_A4670(srtB)
BCB: BCB4264_A4652(srtB)
BCU: BCAH820_4657(srtB)
BCG: BCG9842_B0585(srtB)
BCQ: BCQ_4349
BCX: BCA_4649(srtB)
BNC: BCN_4444
BCF: bcf_22740
BCER: BCK_12530
BTL: BALH_4127
BTB: BMB171_C4188(srtB)
BTT: HD73_4837
BTHI: BTK_23840
BTC: CT43_CH4563(srtB)
BTM: MC28_3823
BTI: BTG_26160
BTW: BF38_296(srtB)
BWW: bwei_0353(srtB)
BMYO: BG05_1500(srtB)
BWD: CT694_24275(srtB)
BCL: ABC3419
BPU: BPUM_3523
BPUM: BW16_18665
BPUS: UP12_18080
BACW: QR42_17645
BKO: CKF48_02500(srtB)
BALT: CFN77_18595(srtB)
LSP: Bsph_1270
LYB: C3943_04645(srtB) C3943_23795(srtB)
LYZ: DCE79_03350(srtB)
SAU: SA0982(srtB)
SAV: SAV1135
SAW: SAHV_1126
SAM: MW1017(srtB)
SAS: SAS1069
SAR: SAR1108(srtB)
SAC: SACOL1145(srtB)
SAA: SAUSA300_1034(srtB)
SAE: NWMN_1046(srtB)
SAD: SAAV_1101(srtB)
SUE: SAOV_1131(srtB)
SUJ: SAA6159_00989(srtB)
SUK: SAA6008_01089(srtB)
SUC: ECTR2_989(srtB)
SUQ: HMPREF0772_12098(srtB)
SUZ: MS7_1091(srtB)
SUX: SAEMRSA15_09640(srtB)
SUW: SATW20_11290(srtB)
SUG: SAPIG1131(srtB)
SUF: SARLGA251_10470(srtB)
SAUA: SAAG_02243
SAUE: RSAU_001019(srtB)
SAUS: SA40_1005(srtB)
SAUU: SA957_1020(srtB)
SAUG: SA268_1023(srtB)
SAUZ: SAZ172_1134(srtB)
SAUF: X998_1132(srtB)
SAB: SAB0999(srtB)
SUY: SA2981_1091(srtB)
SAUB: C248_1161(srtB)
SAUC: CA347_1049(srtB)
SAUR: SABB_02601
SAUI: AZ30_05425
SAUD: CH52_00215
SAMS: NI36_05465
SLN: SLUG_00990(srtB)
SSCU: CEP64_00985(srtB)
LMO: lmo2181
LMOC: LMOSLCC5850_2249(srtB)
LMOE: BN418_2631
LMOB: BN419_2635
LMOD: LMON_2257
LMOW: AX10_05200
LMOM: IJ09_14005
LMP: MUO_11200
LMOL: LMOL312_2200(srtB)
LMOZ: LM1816_08063(srtB)
LMOX: AX24_08815
LMH: LMHCC_0362(srtB)
LMQ: LMM7_2283(srtB)
LML: lmo4a_2242(srtB)
LMS: LMLG_0835
LMW: LMOSLCC2755_2249(srtB)
LMX: LMOSLCC2372_2249(srtB)
LMZ: LMOSLCC2482_2247(srtB)
LMON: LMOSLCC2376_2138(srtB)
LMOS: LMOSLCC7179_2159(srtB)
LMOO: LMOSLCC2378_2212(srtB)
LMOY: LMOSLCC2479_2246(srtB)
LMOT: LMOSLCC2540_2280(srtB)
LMOA: LMOATCC19117_2206(srtB)
LMOK: CQ02_11325
LIN: lin2285
LWE: lwe2198
LSG: lse_2161
LIV: LIV_2168
BTHS: CNY62_10220(srtB)
GEQ: CG018_00440(srtB)
PPM: PPSC2_25225(srtB)
PPO: PPM_5011(srtB)
PPOY: RE92_12035
PLW: D5F53_30420(srtB)
SPOS: DV702_13410(srtB)
SPY: SPy_0129
SPZ: M5005_Spy0110(eftLSL.B)
SPYM: M1GAS476_0146(eftLSL.B)
SPYA: A20_0157(srtB)
SPS: SPs0103
SPK: MGAS9429_Spy0114(eftLSL-B)
SPF: SpyM50107(srtB)
SPB: M28_Spy0110(eftLSL.B)
STG: MGAS15252_0147(srtB)
STX: MGAS1882_0147(srtB)
STZ: SPYALAB49_000150(srtB)
SPYH: L897_00810
SNT: SPT_1060(srtB) SPT_1061
SPNN: T308_04935
SNP: SPAP_1191(srtG2) SPAP_1192(srtG1)
SSA: SSA_0022(srtB)
SGO: SGO_2104(srtB)
SDS: SDEG_1778(eftLSL-B)
SDA: GGS_1595 GGS_1598(eftLSL-B)
SOR: SOR_1066(srtG2) SOR_1067(srtG1)
SCP: HMPREF0833_11498(srtB)
SCF: Spaf_0023(srtB)
STF: Ssal_02063(srtB)
STJ: SALIVA_0123(srtB)
SANS: DK43_03820
EDU: LIU_10275
CML: BN424_3051(srtB)
CPE: CPE0513
CPF: CPF_0492
CPR: CPR_0479
CPAS: Clopa_0028
CBV: U729_544(srtB) U729_752(srtB)
CCEL: CCDG5_1783
RUM: CK1_26390
RUS: RBI_I01301(srtB) RBI_I01670 RBI_II00594(srtB2)
FPR: FP2_31430
RIX: RO1_43060
BLAU: DQQ01_00575(srtB) DQQ01_00895(srtB) DQQ01_03525(srtB) DQQ01_05635(srtB) DQQ01_07460(srtB)
CPY: Cphy_0567
HSD: SD1D_1085
LUA: D4A81_00790(srtB) D4A81_05610(srtB) D4A81_05775(srtB)
ERT: EUR_14280
ERA: ERE_28470
LBW: C3V36_03145(srtB)
AWO: Awo_c20050(srtB)
OVA: OBV_10200
CMIU: B1H56_05920(srtB) B1H56_09840(srtB) B1H56_10750(srtB) B1H56_12645(srtB)
MDV: C5Q96_04910(srtB)
AMIJ: EQM06_07460(srtB)
BPRM: CL3_30560
BPRS: CK3_05330
CBAR: PATL70BA_2784(srtB)
APR: Apre_1386
PMIC: NW74_06215
APV: Apar_0032
OLS: Olsu_0035
 » show all
Taxonomy
Reference
1  [PMID:14725770]
  Authors
Zong Y, Mazmanian SK, Schneewind O, Narayana SV
  Title
The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.
  Journal
Structure 12:105-12 (2004)
DOI:10.1016/j.str.2003.11.021
  Sequence
Reference
2  [PMID:15028680]
  Authors
Bierne H, Garandeau C, Pucciarelli MG, Sabet C, Newton S, Garcia-del Portillo F, Cossart P, Charbit A
  Title
Sortase B, a new class of sortase in Listeria monocytogenes.
  Journal
J Bacteriol 186:1972-82 (2004)
DOI:10.1128/JB.186.7.1972-1982.2004
Reference
3  [PMID:15102780]
  Authors
Comfort D, Clubb RT
  Title
A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria.
  Journal
Infect Immun 72:2710-22 (2004)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.71
IUBMB Enzyme Nomenclature: 3.4.22.71
ExPASy - ENZYME nomenclature database: 3.4.22.71
BRENDA, the Enzyme Database: 3.4.22.71

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