| Entry |
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| Name |
renin;
angiotensin-forming enzyme;
angiotensinogenase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
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| Reaction(IUBMB) |
Cleavage of Leu! bond in angiotensinogen to generate angiotensin I
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| Comment |
Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).
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| History |
EC 3.4.23.15 created 1961 as EC 3.4.4.15, transferred 1972 to EC 3.4.99.19, transferred 1981 to EC 3.4.23.15
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| Orthology |
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| Genes |
| MMU: | 19701(Ren1) 19702(Ren2) |
| MDO: | 100016857 100017009 100017048 100017089 100017171 100618729 |
| GAS: | 123243981 123244828 123245961 123245962 123247900 123247901 |
| SANH: | 107683898 107702841(ren) |
| CCAR: | 109054870 109067585 109070272 |
| CAUA: | 113070732 113107375 |
| SASA: | 106566646 106571888 |
| SALP: | 111966170 111972574 |
| CCLU: | 121537548 121546534 |
| AANG: | 118207472 118210736(ren) |
| PSPA: | 121299963 121304643 |
| ARUT: | 117397667 117433153 117964495 117968795 |
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| Reference |
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| Authors |
Inagami T, Murakami K. |
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| Title |
Pure Renin. Isolation from hog kidney and characterization. |
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| Journal |
J Biol Chem 252:2978-83 (1977) |
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| Reference |
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| Authors |
Slater EE. |
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| Title |
Renin. |
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| Journal |
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| Reference |
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| Authors |
Inagami T |
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| Title |
Structure and function of renin. |
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| Journal |
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| Reference |
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| Authors |
Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN. |
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| Title |
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.23.15 |
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