| Entry |
|
|---|
| Name |
renin;
angiotensin-forming enzyme;
angiotensinogenase
|
|---|
| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
|
|---|
| Reaction(IUBMB) |
Cleavage of Leu! bond in angiotensinogen to generate angiotensin I
|
|---|
| Comment |
Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).
|
|---|
| History |
EC 3.4.23.15 created 1961 as EC 3.4.4.15, transferred 1972 to EC 3.4.99.19, transferred 1981 to EC 3.4.23.15
|
|---|
| Orthology |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
Inagami T, Murakami K. |
|---|
| Title |
Pure Renin. Isolation from hog kidney and characterization. |
|---|
| Journal |
J Biol Chem 252:2978-83 (1977) |
|---|
| Reference |
|
|---|
| Authors |
Slater EE. |
|---|
| Title |
Renin. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Inagami T |
|---|
| Title |
Structure and function of renin. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN. |
|---|
| Title |
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.23.15 |
|
|---|
