KEGG   ENZYME: 3.4.23.15
Entry
EC 3.4.23.15                Enzyme                                 
Name
renin;
angiotensin-forming enzyme;
angiotensinogenase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Cleavage of Leu! bond in angiotensinogen to generate angiotensin I
Comment
Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.15 created 1961 as EC 3.4.4.15, transferred 1972 to EC 3.4.99.19, transferred 1981 to EC 3.4.23.15
Orthology
K01380  renin
Genes
HSA5972(REN)
PTR469651(REN)
PPS100984353(REN)
GGO101130437(REN)
PON100435070(REN)
NLE100592810(REN)
MCC574299(REN)
MCF102122446(REN)
CSAB103230256(REN)
CATY105576029(REN)
PANU101018390(REN)
TGE112634039(REN)
RRO104667395(REN)
RBB108535194(REN)
TFN117075586(REN)
PTEH111522776(REN)
CJC100399036(REN)
SBQ101036357(REN)
CSYR103274411(REN)
MMUR105869290(REN)
LCAT123626885(REN)
OGA100952097(REN)
MMU19701(Ren1) 19702(Ren2)
MCAL110292479(Ren)
MPAH110322198(Ren)
RNO24715(Ren)
MCOC116099326(Ren)
MUN110546748(Ren)
CGE100763117(Ren)
MAUA101842518(Ren)
PLEU114698044(Ren)
MORG121446565(Ren)
AAMP119828011(Ren)
NGI103731872(Ren)
HGL101725618(Ren)
CPOC100724037(Ren)
CCAN109698788(Ren)
DORD105986474(Ren)
DSP122109515(Ren)
NCAR124962370
OCU100358545(REN)
OPI101517787(REN)
TUP102486665(REN)
CFA403838(REN)
CLUD112643248(REN)
VVP112914400(REN)
VLG121501319(REN)
AML100470089(REN)
UMR103657747(REN)
UAH113242509(REN)
UAR123785707(REN)
ELK111151146
LLV125085972
MPUF101694500(REN)
ORO101380830(REN)
EJU114221868(REN)
ZCA113932910(REN)
MLX118013674(REN)
FCA101081695(REN)
PYU121021648(REN)
PBG122475872(REN)
PTG102965512(REN)
PPAD109256860(REN)
AJU106972902(REN)
HHV120228933(REN)
BTA280909(REN)
BOM102267598(REN)
BIU109570766(REN)
BBUB102394688(REN)
CHX102190154(REN)
OAS443310(REN)
ODA120879880(REN)
CCAD122451911(REN)
SSC100524822(REN)
CFR102506297(REN)
CBAI105078433(REN)
CDK105098650(REN)
VPC102527009(REN)
BACU103009645(REN)
LVE103068873(REN)
OOR101284037(REN)
DLE111184622(REN)
PCAD102980173(REN)
PSIU116742821(REN)
ECB100054248(REN)
EPZ103557494(REN)
EAI106822997(REN)
MYB102262750(REN)
MYD102762390(REN)
MMYO118673786(REN)
MNA107538629(REN)
PKL118721667(REN)
HAI109386469(REN)
DRO112314863(REN)
SHON119001671(REN)
AJM119055067(REN)
PDIC114512024(REN)
PHAS123820662(REN)
MMF118637934(REN)
RFQ117015129(REN)
PALE102898369(REN)
PVP105300684(REN)
RAY107508230(REN)
MJV108391626(REN)
TOD119234263(REN)
SARA101549468(REN)
LAV100653930(REN)
TMU101361683
DNM101432688(REN)
MDO100016857 100017009 100017048 100017089 100017171 100618729
GAS123243981 123244828 123245961 123245962 123247900 123247901
SHR100935150(REN)
PCW110219584(REN)
OAA100092330(REN)
GGA431167(REN)
PCOC116237093(REN)
MGP100544109(REN)
CJO107324665(REN)
NMEL110388076(REN)
APLA101800278(REN)
ACYG106041262(REN)
AFUL116498679(REN)
TGU115498536(REN)
LSR110475004(REN)
PMOA120499104(REN)
OTC121345504(REN)
PRUF121355250(REN)
GFR102032412(REN)
FAB101811288(REN)
PHI102103389(REN)
PMAJ107214777(REN)
CCAE111939690(REN)
CCW120411274(REN)
CBRC103625384(REN)
ETL114069117(REN)
ZAB102075270
FPG101916979(REN)
FCH102049731(REN)
CLV102093221(REN)
EGZ104125792(REN)
NNI104013208(REN)
ACUN113488782(REN)
TALA104359087(REN)
PADL103919859(REN)
ACHC115335477(REN)
HALD104320571
CCRI104167002(REN)
CSTI104562143(REN)
EHS104514014(REN)
CMAC104483348(REN)
FGA104074689(REN)
GSTE104256729(REN)
LDI104355007(REN)
MNB103778582(REN)
OHA104328204(REN)
AAM106484864(REN)
AROW112971650(REN)
NPD112959127(REN)
DNE112990286(REN)
ASN102387440(REN)
AMJ102563732(REN)
CPOO109317753(REN)
GGN109295222(REN)
PSS102463928(REN)
CMY102937199(REN)
CPIC101934640(REN)
TST117875812(REN)
CABI116827881(REN)
MRV120404525(REN)
ACS100557560(ren)
PVT110081398(REN)
SUND121928633(REN)
PBI103048990(REN)
PMUR107302993(REN)
TSR106557103(REN)
PGUT117664390(REN)
VKO123031044(REN)
PMUA114599283(REN)
ZVI118088539(REN)
GJA107107084(REN)
STOW125432913(REN)
XLA108709447(ren.S)
XTR100487524(ren)
NPR108804894(REN)
RTEM120927129(REN)
BBUF120993324(REN)
BGAR122932868(REN)
DRE405786(ren)
SRX107727110 107747224
SANH107683898 107702841(ren)
SGH107550929 107570508
CCAR109054870 109067585 109070272
CAUA113070732 113107375
PPRM120485994(ren)
MAMB125279764(ren)
IPU108265134(ren)
PHYP113533495
SMEO124399494(ren)
TFD113656325(ren)
AMEX103036504
EEE113578769(ren)
TRU777957(ren)
TNGGSTEN00033243G001
LCO104927909
NCC104956331(ren)
CGOB115011106(ren)
ELY117258621(ren)
EFO125892099(ren)
PLEP121947084(ren)
SLUC116062097(ren)
ECRA117947826(ren)
PFLV114559029(ren)
GAT120828707(ren)
PPUG119222679(ren)
MSAM119905982(ren)
CUD121517750(ren)
ALAT119022665(ren)
MZE101472021
ONL100691504
OAU116324774(ren)
OLA101168210
OML112159510(ren)
XMA102237116(ren)
XCO114144744(ren)
XHE116719432(ren)
PRET103467540(ren)
PFOR103145051(ctse)
PLAI106940528(ren)
PMEI106907869(ren)
GAF122830051(ren)
CVG107090387
CTUL119774136(ren)
GMU124860834(ren)
NFU107391136(ren)
KMR108231996(ren)
ALIM106522579(ctse)
NWH119416579(ren)
AOCE111576838
MCEP125018351(ren)
CSEM103385502(ctse)
POV109635083
SSEN122777902(ren)
HHIP117764761(ren)
HSP118111106(ren)
LCF108889478
SDU111217305
SLAL111667152
XGL120803999(ren)
HCQ109528441
BPEC110158062
MALB109951129
BSPL114858312(ren)
SASA106566646 106571888
OTW112216579 112222265
OMY110492465 110531962
OGO124021234 124045030
ONE115101624 115132775
SALP111966170 111972574
SNH120058995 120061369
CCLU121537548 121546534
ELS105007023
SFM108940277(ren)
AANG118207472 118210736(ren)
LOC102690320(ren)
PSPA121299963 121304643
ARUT117397667 117433153 117964495 117968795
LCM102363906(REN)
CMK103182446
RTP109929130(ren)
DSV119441438
 » show all
Reference
1  [PMID:16012]
  Authors
Inagami T, Murakami K.
  Title
Pure Renin. Isolation from hog kidney and characterization.
  Journal
J Biol Chem 252:2978-83 (1977)
Reference
2  [PMID:7043197]
  Authors
Slater EE.
  Title
Renin.
  Journal
Methods Enzymol 80 Pt C:427-42 (1981)
DOI:10.1016/s0076-6879(81)80037-7
Reference
3  [PMID:2666611]
  Authors
Inagami T
  Title
Structure and function of renin.
  Journal
J Hypertens Suppl 7:S3-8 (1989)
DOI:10.1097/00004872-198904002-00002
Reference
4  [PMID:2493678]
  Authors
Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN.
  Title
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution.
  Journal
Science 243:1346-51 (1989)
DOI:10.1126/science.2493678
  Sequence
[hsa:5972]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.15
IUBMB Enzyme Nomenclature: 3.4.23.15
ExPASy - ENZYME nomenclature database: 3.4.23.15
BRENDA, the Enzyme Database: 3.4.23.15
CAS: 9015-94-5

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