KEGG   ENZYME: 3.4.23.15Help
Entry
EC 3.4.23.15                Enzyme                                 

Name
renin;
angiotensin-forming enzyme;
angiotensinogenase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Leu! bond in angiotensinogen to generate angiotensin I
Comment
Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.15 created 1961 as EC 3.4.4.15, transferred 1972 to EC 3.4.99.19, transferred 1981 to EC 3.4.23.15
Orthology
K01380  renin
Genes
HSA: 5972(REN)
PTR: 469651(REN)
PPS: 100984353(REN)
GGO: 101130437(REN)
PON: 100435070(REN)
NLE: 100592810(REN)
MCC: 574299(REN)
MCF: 102122446(REN)
CSAB: 103230256(REN)
RRO: 104667395(REN)
RBB: 108535194(REN)
CJC: 100399036(REN)
SBQ: 101036357(REN)
MMU: 19701(Ren1) 19702(Ren2)
RNO: 24715(Ren)
CGE: 100763117(Ren)
NGI: 103731872(Ren)
HGL: 101725618(Ren)
CCAN: 109698788(Ren)
OCU: 100358545(REN)
TUP: 102486665(REN)
CFA: 403838(REN)
AML: 100470089(REN)
UMR: 103657747(REN)
ORO: 101380830(REN)
FCA: 101081695(REN)
PTG: 102965512(REN)
AJU: 106972902(REN)
BTA: 280909(REN)
BOM: 102267598(REN)
BIU: 109570766(REN)
PHD: 102320122(REN)
CHX: 102190154(REN)
OAS: 443310(REN)
SSC: 100524822(REN)
CFR: 102506297(REN)
CDK: 105098650(REN)
BACU: 103009645(REN)
LVE: 103068873(REN)
OOR: 101284037(REN)
ECB: 100054248(REN)
EPZ: 103557494(REN)
EAI: 106822997(REN)
MYB: 102262750(REN)
MYD: 102762390(REN)
HAI: 109386469(REN)
RSS: 109434463(REN)
PALE: 102898369(REN)
LAV: 100653930(REN)
TMU: 101361683
MDO: 100017048
SHR: 100935150(REN)
OAA: 100092330(CTSE)
GGA: 431167(REN)
MGP: 100544109(REN)
CJO: 107324665(REN)
APLA: 101800278(REN)
ACYG: 106041262(REN)
GFR: 102032412(REN)
FAB: 101811288(REN)
PHI: 102103389(REN)
PMAJ: 107214777(REN)
CCAE: 111939690(REN)
FPG: 101916979(REN)
FCH: 102049731(REN)
CLV: 102093221(REN)
EGZ: 104125792(REN)
AAM: 106484864(REN)
ASN: 102387440(REN)
AMJ: 102563732(REN)
PSS: 102463928(REN)
CMY: 102937199(REN)
CPIC: 101934640(REN)
ACS: 100557560(ren)
PVT: 110081398(REN)
PBI: 103048990(REN)
GJA: 107107084(REN)
XLA: 108709447(ren.S)
XTR: 100487524(ren)
NPR: 108804894(REN)
DRE: 405786(ren)
SANH: 107683898 107702841(ren)
IPU: 108265134(ren)
AMEX: 103036504
TRU: 777957(ren)
LCO: 104927909(ren)
NCC: 104956331(ren)
MZE: 101472021
OLA: 101168210
XMA: 102237116(ren)
PRET: 103467540(ren)
NFU: 107391136(ren)
KMR: 108231996(ren)
CSEM: 103385502(ctse)
LCF: 108889478
SDU: 111217305
HCQ: 109528441
BPEC: 110158062
MALB: 109951129
ELS: 105007023
SFM: 108940277(ren)
LCM: 102363906(REN)
CMK: 103182446(ren)
 » show all
Taxonomy
Reference
1  [PMID:16012]
  Authors
Inagami T, Murakami K.
  Title
Pure Renin. Isolation from hog kidney and characterization.
  Journal
J Biol Chem 252:2978-83 (1977)
Reference
2  [PMID:7043197]
  Authors
Slater EE.
  Title
Renin.
  Journal
Methods Enzymol 80 Pt C:427-42 (1981)
Reference
3  [PMID:2666611]
  Authors
Inagami T
  Title
Structure and function of renin.
  Journal
J Hypertens Suppl 7:S3-8 (1989)
Reference
4  [PMID:2493678]
  Authors
Sielecki AR, Hayakawa K, Fujinaga M, Murphy ME, Fraser M, Muir AK, Carilli CT, Lewicki JA, Baxter JD, James MN.
  Title
Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution.
  Journal
Science 243:1346-51 (1989)
DOI:10.1126/science.2493678
  Sequence
[hsa:5972]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.15
IUBMB Enzyme Nomenclature: 3.4.23.15
ExPASy - ENZYME nomenclature database: 3.4.23.15
BRENDA, the Enzyme Database: 3.4.23.15
CAS: 9015-94-5

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