KEGG   ENZYME: 3.4.23.3
Entry
EC 3.4.23.3                 Enzyme                                 

Name
gastricsin;
pepsin C;
pig parapepsin II;
parapepsin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin
Comment
Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986
Orthology
K01377  gastricsin
Genes
HSA: 5225(PGC)
PTR: 107975138(PGC) 469410
PPS: 100974556(PGC)
GGO: 101129549(PGC)
PON: 100271706(PGC)
NLE: 100583614(PGC)
MCC: 695713(PGC)
MCF: 102124827(PGC)
CSAB: 103221511(PGC)
CATY: 105591935(PGC)
PANU: 100137209(PGC)
RRO: 104667302(PGC)
RBB: 108533509(PGC)
TFN: 117087201(PGC)
PTEH: 111543032(PGC)
CJC: 100404738(PGC)
SBQ: 101046472(PGC)
MMUR: 105864060 105875872(PGC)
MMU: 109820(Pgc)
MCAL: 110284112(Pgc)
MPAH: 110335889(Pgc)
RNO: 24864(Pgc)
MCOC: 116074734(Pgc)
MUN: 110550245(Pgc)
CGE: 100770180(Pgc)
PLEU: 114705363(Pgc)
NGI: 103725818(Pgc)
HGL: 101713573(Pgc)
CCAN: 109682091(Pgc) 109690302
OCU: 100009323(PGC)
OPI: 101533754(PGC)
TUP: 102468155(PGC) 102471668
CFA: 403552(PGB1) 609052(PGC)
AML: 100465306(PGC) 100474233(PGB2)
UAH: 113261042(PGC)
ORO: 101370826(PGC) 101377876
EJU: 114204670(PGC) 114208059
MLX: 118000901(PGC) 118018937
FCA: 101100053(PGC) 111556254
AJU: 106969657 106974058(PGC)
BTA: 514502(PGC)
BOM: 102288190(PGC)
BIU: 109577457(PGC)
BBUB: 102407704(PGC)
CHX: 102189914(PGC)
OAS: 101106633(PGC)
ODA: 120870136(PGC)
CCAD: 122429554(PGC)
SSC: 100521201(PGC) 100620249
CFR: 102523783(PGC)
CBAI: 105083768(PGC)
CDK: 105086751(PGC)
BACU: 103010186(PGC)
LVE: 103070634(PGC)
OOR: 101276675(PGC)
DLE: 111178617(PGC)
PCAD: 102984618(PGC)
ECB: 100066460(PGC)
EPZ: 103563497(PGC)
EAI: 106824587(PGC)
MYB: 102255177(PGC) 102261843
MYD: 102755151(PGC) 102772869
MMYO: 118660362(PGC) 118673372
MNA: 107536852(PGC) 107545243
PKL: 118705507(PGC) 118727498
HAI: 109373549 109382920(PGC)
DRO: 112302163(PGC)
SHON: 118993918(PGC)
AJM: 119055617(PGC)
MMF: 118621577(PGC) 118637873
PALE: 102877967(PGC) 102881919
PGIG: 120584944 120596277(PGC)
RAY: 107501928(PGC)
MJV: 108389526 108395077(PGC)
TOD: 119235236 119252449(PGC)
LAV: 100665648(PGC) 100675371
GGA: 395690(PGC) 428272(GASTL)
ACYG: 106045837(PGC) 106045861
TGU: 105758893(PGC)
LSR: 110477157(PGC)
SCAN: 103823313(PGC)
PMOA: 120495962(PGC)
OTC: 121348014(PGC)
PRUF: 121354004(PGC)
GFR: 102041764(PGC)
FAB: 101807666(PGC)
CCW: 104692528 120411261(PGC)
CLV: 102091578(PGC)
NNI: 104013154 104013155(PGC)
PADL: 103919814(PGC) 103919816
CPOO: 109317680 109317781(PGC)
PVT: 110081367 110081374(PGC)
TSR: 106540681(PGC)
PGUT: 117658762
XLA: 108704545 108704546 108709103 108709104(pgc.S) 373563(XB964428.S)
LCO: 104940478
CGOB: 115009416
ELY: 117262167
PLEP: 121949848
SLUC: 116045622
ECRA: 117949579
PFLV: 114559916
GAT: 120808852
PPUG: 119195564
MSAM: 119893771
POV: 109624424(pgc)
LCF: 108875170(pgc)
SDU: 111228596(pgc)
SLAL: 111671242
XGL: 120792717
MALB: 109967483
OTW: 112218646
AANG: 118219157
LOC: 102686226 102693407(pgc)
LCM: 102354616(PGC)
RSAN: 119373383
BMY: BM_BM3492(Bma-hrg-7)
 » show all
Reference
1
  Authors
Ryle, A.P.
  Title
The porcine pepsins and pepsinogens.
  Journal
Methods Enzymol 19:316-336 (1970)
Reference
2
  Authors
Tang, J.
  Title
Gastricsin and pepsin.
  Journal
Methods Enzymol 19:406-421 (1970)
Reference
3  [PMID:6795036]
  Authors
Foltmann B.
  Title
Gastric proteinases--structure, function, evolution and mechanism of action.
  Journal
Essays Biochem 17:52-84 (1981)
Reference
4  [PMID:6816595]
  Authors
Foltmann B, Jensen AL.
  Title
Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.
  Journal
Eur J Biochem 128:63-70 (1982)
DOI:10.1111/j.1432-1033.1982.tb06931.x
  Sequence
[hsa:5225]
Reference
5  [PMID:6800788]
  Authors
Martin P, Trieu-Cuot P, Collin JC, Ribadeau Dumas B.
  Title
Purification and characterization of bovine gastricsin.
  Journal
Eur J Biochem 122:31-9 (1982)
DOI:10.1111/j.1432-1033.1982.tb05844.x
Reference
6  [PMID:6432332]
  Authors
Reid WA, Vongsorasak L, Svasti J, Valler MJ, Kay J.
  Title
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.
  Journal
Cell Tissue Res 236:597-600 (1984)
DOI:10.1007/bf00217228
Reference
7  [PMID:3335549]
  Authors
Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K.
  Title
Primary structure of human pepsinogen C gene.
  Journal
J Biol Chem 263:1382-5 (1988)
  Sequence
[hsa:5225]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.3
IUBMB Enzyme Nomenclature: 3.4.23.3
ExPASy - ENZYME nomenclature database: 3.4.23.3
BRENDA, the Enzyme Database: 3.4.23.3
CAS: 9012-71-9

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