KEGG ENZYME: 3.4.23.3

ENZYME: 3.4.23.3

Entry

EC 3.4.23.3 Enzyme

Name

gastricsin;
pepsin C;
pig parapepsin II;
parapepsin II

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases

Reaction(IUBMB)

More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin

Comment

Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).

History

EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986

Orthology

K01377

gastricsin

Genes

HSA:

5225(PGC)

PTR:	107975138(PGC) 469410

PPS:	100974556(PGC)

GGO:	101129549(PGC)

PON:	100271706(PGC)

NLE:	100583614(PGC)

MCC:	695713(PGC)

MCF:	102124827(PGC)

CSAB:

103221511(PGC)

CATY:

105591935(PGC)

PANU:

100137209(PGC)

RRO:	104667302(PGC)

RBB:	108533509(PGC)

TFN:	117087201(PGC)

PTEH:

111543032(PGC)

CJC:	100404738(PGC)

SBQ:	101046472(PGC)

MMUR:

105864060 105875872(PGC)

MMU:	109820(Pgc)

MCAL:

110284112(Pgc)

MPAH:

110335889(Pgc)

RNO:	24864(Pgc)

MCOC:

116074734(Pgc)

MUN:	110550245(Pgc)

CGE:	100770180(Pgc)

PLEU:

114705363(Pgc)

NGI:	103725818(Pgc)

HGL:	101713573(Pgc)

CCAN:

109682091(Pgc) 109690302

OCU:	100009323(PGC)

OPI:	101533754(PGC)

TUP:	102468155(PGC) 102471668

CFA:	403552(PGB1) 609052(PGC)

VVP:	112907206 112907886 112914212(PGC)

VLG:	121472163(PGC) 121486385 121487121

AML:	100465306(PGC) 100474233(PGB2)

UMR:	103664167(PGC) 103675035 103675037

UAH:	113261042(PGC)

ORO:	101370826(PGC) 101377876

ELK:	111142948 111142951 111147505

MPUF:

101689476 101693498(PGC) 101693781

EJU:	114204670(PGC) 114208059

MLX:	118000901(PGC) 118018937

FCA:	101100053(PGC) 111556254

PYU:	121026647 121026649 121029436(PGC)

PBG:	122479442 122479635 122489504(PGC)

PTG:	102948554(PGC) 102964203 102965559

PPAD:

109271603(PGC) 109272037 109272192

AJU:	106969657 106974058(PGC)

HHV:	120223472 120223490 120238740(PGC)

BTA:	514502(PGC)

BOM:	102288190(PGC)

BIU:	109577457(PGC)

BBUB:

102407704(PGC)

CHX:	102189914(PGC)

OAS:	101106633(PGC)

ODA:	120870136(PGC)

CCAD:

122429554(PGC)

SSC:	100521201(PGC) 100620249

CFR:	102523783(PGC)

CBAI:

105083768(PGC)

CDK:	105086751(PGC)

BACU:

103010186(PGC)

LVE:	103070634(PGC)

OOR:	101276675(PGC)

DLE:	111178617(PGC)

PCAD:

102984618(PGC)

ECB:	100066460(PGC)

EPZ:	103563497(PGC)

EAI:	106824587(PGC)

MYB:	102255177(PGC) 102261843

MYD:	102755151(PGC) 102772869

MMYO:

118660362(PGC) 118673372

MNA:	107536852(PGC) 107545243

PKL:	118705507(PGC) 118727498

HAI:	109373549 109382920(PGC)

DRO:	112302163(PGC)

SHON:

118993918(PGC)

AJM:	119055617(PGC)

MMF:	118621577(PGC) 118637873

PALE:

102877967(PGC) 102881919

PGIG:

120584944 120596277(PGC)

RAY:	107501928(PGC)

MJV:	108389526 108395077(PGC)

TOD:	119235236 119252449(PGC)

LAV:	100665648(PGC) 100675371

TMU:	101349705 101353827

MDO:	100027327 100027345 100027368 100027389 554184(PGC)

SHR:	100917515 100919336 116423409

PCW:	110204032 110204033 110216792

GGA:	395690(PGC) 428272(GASTL)

PCOC:

116236958 116237053

MGP:	100546064 100546220

CJO:	107324900 107324901

NMEL:

110388247 110388248

APLA:

101792780 101794692

ACYG:

106045837(PGC) 106045861

TGU:	105758893(PGC)

LSR:	110477157(PGC)

SCAN:

103823313(PGC)

PMOA:

120495962(PGC)

OTC:	121348014(PGC)

PRUF:

121354004(PGC)

GFR:	102041764(PGC)

FAB:	101807666(PGC)

PHI:	102107379 102107560

PMAJ:

107214993 107214994

CCW:	104692528 120411261(PGC)

ETL:	114070527 114070528

FPG:	101912673 101912850

FCH:	102048513 106630797

CLV:	102091578(PGC)

EGZ:	104125729 104125730

NNI:	104013154 104013155(PGC)

ACUN:

113488821 113488823

PADL:

103919814(PGC) 103919816

AAM:	106494351 106494352 106494353(PGC)

AROW:

112961416 112961418 112961419

NPD:	112959192(PGC) 112959193 112959194

DNE:	112990287 112990305

ASN:	102368438 102368697 102368950 102380415

AMJ:	102562220 102562457 102564094 106736665(PGC)

CPOO:

109317680 109317781(PGC)

GGN:	109295112 109295383 109295384 109295385(PGC)

PSS:	102443428 102443684 102463493 102463918

CMY:	102941343 102941576 119564418

CPIC:

101944245 101944509 101944783 101945053

TST:	117875842 117875843 117875844 117875845

CABI:

116817833 116818103 116818123 116818131

ACS:	100566938 100567135 100567523

PVT:	110081367 110081374(PGC)

PBI:	103055509 103056934 103066093

PMUR:

107291548 107299949 107299950 107300480

TSR:	106540681(PGC)

PGUT:

117658762

PMUA:

114598354 114598355 114598356 114598357

ZVI:	118088671 118089240 118089241 118089242

GJA:	107107325 107107326 107107327 107107328

XLA:	108704545 108704546 108709103 108709104(pgc.S) 373563(XB964428.S)

XTR:	100489782 496913 548353(pgc) 594991(pgc) 613072

NPR:	108804878 108804879 108804887 108804890 108804897 108804900

IPU:	108264667 108264668 108264669 108264670 108266400 108266401

PHYP:

113524721 113526108 113534331

AMEX:

103027414(pgc) 103031313 103038890

EEE:	113577941 113577942 113577957 113580521(pgc)

LCO:

CGOB:

ELY:

PLEP:

SLUC:

ECRA:

PFLV:

GAT:

PPUG:

MSAM:

AOCE:

POV:	109624424(pgc)

LCF:	108875170(pgc)

SDU:	111228596(pgc)

SLAL:

XGL:

MALB:

SASA:

OTW:

OMY:	110496598 110496606 110496614

SALP:

112068576 112077499 112078742

SNH:	120025049 120025060 120025071

ELS:	105022187 105022190

SFM:	108924268 108936564 108936565 108936566 108936567

PKI:	111842453(pgc) 111858572 111859331

AANG:

118219157

LOC:	102686226 102693407(pgc)

PSPA:

121299561 121299841 121299845 121299847 121300146 121322055 121323511

ARUT:

117396739 117396750 117396758 117407111 117426727 117426791 117432862 117964470

LCM:	102354616(PGC)

RTP:	109913610 109919765

RSAN:

119373383

BMY:	BM_BM3492(Bma-hrg-7)

LOA:	LOAG_08037

OVI:	T265_12844

» show all

Reference

Authors

Ryle, A.P.

Title

The porcine pepsins and pepsinogens.

Journal

Methods Enzymol 19:316-336 (1970)

Reference

Authors

Tang, J.

Title

Gastricsin and pepsin.

Journal

Methods Enzymol 19:406-421 (1970)

Reference

3 [PMID:6795036]

Authors

Foltmann B.

Title

Gastric proteinases--structure, function, evolution and mechanism of action.

Journal

Essays Biochem 17:52-84 (1981)

Reference

4 [PMID:6816595]

Authors

Foltmann B, Jensen AL.

Title

Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.

Journal

Eur J Biochem 128:63-70 (1982)
DOI:10.1111/j.1432-1033.1982.tb06931.x

Sequence

[hsa:5225]

Reference

5 [PMID:6800788]

Authors

Martin P, Trieu-Cuot P, Collin JC, Ribadeau Dumas B.

Title

Purification and characterization of bovine gastricsin.

Journal

Eur J Biochem 122:31-9 (1982)
DOI:10.1111/j.1432-1033.1982.tb05844.x

Reference

6 [PMID:6432332]

Authors

Reid WA, Vongsorasak L, Svasti J, Valler MJ, Kay J.

Title

Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.

Journal

Cell Tissue Res 236:597-600 (1984)
DOI:10.1007/bf00217228

Reference

7 [PMID:3335549]

Authors

Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K.

Title

Primary structure of human pepsinogen C gene.

Journal

J Biol Chem 263:1382-5 (1988)

Sequence

[hsa:5225]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.23.3

IUBMB Enzyme Nomenclature:

3.4.23.3

ExPASy - ENZYME nomenclature database:

3.4.23.3

BRENDA, the Enzyme Database:

3.4.23.3

CAS:

9012-71-9

DBGET integrated database retrieval system