Entry |
|
Name |
gastricsin;
pepsin C;
pig parapepsin II;
parapepsin II
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
|
Reaction(IUBMB) |
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin
|
Comment |
Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).
|
History |
EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986
|
Orthology |
|
Genes |
» show all
|
Reference |
1 |
Authors |
Ryle, A.P. |
Title |
The porcine pepsins and pepsinogens. |
Journal |
Methods Enzymol 19:316-336 (1970) |
Reference |
2 |
Authors |
Tang, J. |
Title |
Gastricsin and pepsin. |
Journal |
Methods Enzymol 19:406-421 (1970) |
Reference |
|
Authors |
Foltmann B. |
Title |
Gastric proteinases--structure, function, evolution and mechanism of action. |
Journal |
Essays Biochem 17:52-84 (1981) |
Reference |
|
Authors |
Foltmann B, Jensen AL. |
Title |
Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Martin P, Trieu-Cuot P, Collin JC, Ribadeau Dumas B. |
Title |
Purification and characterization of bovine gastricsin. |
Journal |
|
Reference |
|
Authors |
Reid WA, Vongsorasak L, Svasti J, Valler MJ, Kay J. |
Title |
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate. |
Journal |
|
Reference |
|
Authors |
Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K. |
Title |
Primary structure of human pepsinogen C gene. |
Journal |
J Biol Chem 263:1382-5 (1988) |
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 3.4.23.3 |
ExPASy - ENZYME nomenclature database: | 3.4.23.3 |
|