KEGG   ENZYME: 3.4.23.3Help
Entry
EC 3.4.23.3                 Enzyme                                 

Name
gastricsin;
pepsin C;
pig parapepsin II;
parapepsin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin
Comment
Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986
Orthology
K01377  gastricsin
Genes
HSA: 5225(PGC)
PTR: 107975138(PGC) 469410
PPS: 100974556(PGC)
GGO: 101127433 101129549(PGC)
PON: 100271706(PGC)
NLE: 100583614(PGC)
MCC: 695713(PGC)
MCF: 102124827(PGC)
CSAB: 103221511(PGC)
RRO: 104667302(PGC)
RBB: 108533509(PGC)
CJC: 100404738(PGC)
SBQ: 101046472(PGC)
MMU: 109820(Pgc)
RNO: 24864(Pgc)
CGE: 100770180(Pgc)
NGI: 103725818(Pgc)
HGL: 101713573(Pgc)
CCAN: 109682091(Pgc) 109690302
OCU: 100009323(PGC)
TUP: 102468155(PGC) 102471668
CFA: 403552(PGB) 611675
AML: 100474233 100474492
UMR: 103664167(PGC) 103675035 103675037
ORO: 101370826(PGC) 101377876
FCA: 101100053(PGC) 111556254
PTG: 102948554(PGC) 102964203 102965559
AJU: 106969657 106974058(PGC)
BTA: 514502(PGC)
BOM: 102288190(PGC)
BIU: 109577457(PGC)
PHD: 102341255(PGC)
CHX: 102189914(PGC)
OAS: 101106633(PGC)
SSC: 100521201(PGC) 100620249
CFR: 102523783(PGC)
CDK: 105086751(PGC)
BACU: 103010186(PGC)
LVE: 103070634(PGC)
OOR: 101276675(PGC)
ECB: 100066460(PGC)
EPZ: 103563497(PGC)
EAI: 106824587(PGC) 106828552
MYB: 102255177(PGC) 102261843
MYD: 102755151(PGC) 102772869
HAI: 109373549 109382920(PGC)
RSS: 109446812 109450719(PGC)
PALE: 102877967(PGC) 102881919
LAV: 100665648(PGC) 100675371
TMU: 101342055 101349705 101353827
MDO: 100027327 100027389 554184(PGC)
SHR: 100917515 100919336
GGA: 395690(PGC) 428272(GASTL)
MGP: 100546064 100546220
CJO: 107324900 107324901
APLA: 101792780 101794692
ACYG: 106045837(PGC) 106045861
GFR: 102041764(PGC)
FAB: 101807666(PGC)
PHI: 102107379 102107560
PMAJ: 107214993 107214994
CCAE: 111939668(PGC)
CCW: 104692528(PGC)
FPG: 101912673 101912850
FCH: 102048513 106630797
CLV: 102091578(PGC)
EGZ: 104125729 104125730
AAM: 106494351 106494352 106494353(PGC)
ASN: 102368438 102368697 102368950 102380415
AMJ: 102562220 102562457 102564094 106736665(PGC)
PSS: 102443428 102443684 102463493 102463918
CMY: 102930064(Gastricsin) 102941343(Gastricsin) 102941576(Gastricsin)
CPIC: 101944245 101944509 101944783 101945053
ACS: 100566938 100567135 100567523 107982804
PVT: 110081367 110081374(PGC)
PBI: 103055509 103056934 103066093 103066901
GJA: 107107325 107107326 107107327 107107328
XLA: 108704545 108704546 108709103 108709104 373563(LOC496913.S)
XTR: 100489782 496913 548353(pgc) 594991(pgc) 613072
NPR: 108804878 108804879 108804887 108804890 108804897 108804900
IPU: 108264667 108264668 108264669 108264670 108266400 108266401
AMEX: 103027414(pgc) 103031313 103038890
LCO: 104940478
LCF: 108875170(pgc)
SDU: 111228596(pgc)
MALB: 109967483
SASA: 106561235 106561236
OTW: 112218646
ELS: 105022187 105022190
SFM: 108924268 108936564 108936565 108936566 108936567
LCM: 102354616(PGC)
BMY: Bm1_34740
LOA: LOAG_08037
 » show all
Taxonomy
Reference
1
  Authors
Ryle, A.P.
  Title
The porcine pepsins and pepsinogens.
  Journal
Methods Enzymol 19:316-336 (1970)
Reference
2
  Authors
Tang, J.
  Title
Gastricsin and pepsin.
  Journal
Methods Enzymol 19:406-421 (1970)
Reference
3  [PMID:6795036]
  Authors
Foltmann B.
  Title
Gastric proteinases--structure, function, evolution and mechanism of action.
  Journal
Essays Biochem 17:52-84 (1981)
Reference
4  [PMID:6816595]
  Authors
Foltmann B, Jensen AL.
  Title
Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.
  Journal
Eur J Biochem 128:63-70 (1982)
DOI:10.1111/j.1432-1033.1982.tb06931.x
  Sequence
[hsa:5225]
Reference
5  [PMID:6800788]
  Authors
Martin P, Trieu-Cuot P, Collin JC, Ribadeau Dumas B.
  Title
Purification and characterization of bovine gastricsin.
  Journal
Eur J Biochem 122:31-9 (1982)
DOI:10.1111/j.1432-1033.1982.tb05844.x
Reference
6  [PMID:6432332]
  Authors
Reid WA, Vongsorasak L, Svasti J, Valler MJ, Kay J.
  Title
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.
  Journal
Cell Tissue Res 236:597-600 (1984)
Reference
7  [PMID:3335549]
  Authors
Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K.
  Title
Primary structure of human pepsinogen C gene.
  Journal
J Biol Chem 263:1382-5 (1988)
  Sequence
[hsa:5225]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.3
IUBMB Enzyme Nomenclature: 3.4.23.3
ExPASy - ENZYME nomenclature database: 3.4.23.3
BRENDA, the Enzyme Database: 3.4.23.3
CAS: 9012-71-9

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