KEGG   ENZYME: 3.4.23.3
Entry
EC 3.4.23.3                 Enzyme                                 
Name
gastricsin;
pepsin C;
pig parapepsin II;
parapepsin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin
Comment
Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986
Orthology
K01377  gastricsin
Genes
HSA5225(PGC)
PTR107975138(PGC) 469410
PPS100974556(PGC)
GGO101129549(PGC)
PON100271706(PGC)
NLE100583614(PGC)
MCC695713(PGC)
MCF102124827(PGC)
MTHB126953797
CSAB103221511(PGC)
CATY105591935(PGC)
PANU100137209(PGC)
TGE112623421(PGC)
RRO104667302(PGC)
RBB108533509(PGC)
TFN117087201(PGC)
PTEH111543032(PGC)
CJC100404738(PGC)
SBQ101046472(PGC)
CSYR103264883(PGC) 103271458
MMUR105864060 105875872(PGC)
LCAT123631860(PGC) 123634591
OGA100954923(PGC) 100961595
MMU109820(Pgc)
MCAL110284112(Pgc)
MPAH110335889(Pgc)
RNO24864(Pgc)
MCOC116074734(Pgc)
MUN110550245(Pgc)
CGE100770180(Pgc)
MAUA101831401(Pgc)
PLEU114705363(Pgc)
MORG121451030(Pgc)
MFOT126488949
AAMP119823537(Pgc)
NGI103725818(Pgc)
HGL101713573(Pgc)
CPOC100135598(Pgc)
CCAN109682091(Pgc) 109690302
DORD105987777(Pgc)
DSP122101501(Pgc)
NCAR124988730 124988731 124988979
OCU100009323(PGC)
OPI101533754(PGC)
TUP102468155(PGC) 102471668
CFA403552(PGB1) 609052(PGC)
CLUD112640662 112640663(PGB1) 112641854(PGC) 125755195
VVP112907206 112907886 112914212(PGC)
VLG121472163(PGC) 121486385 121487121
AML100465306(PGC) 100474233(PGB2)
UMR103664167(PGC) 103675035 103675037
UAH113261042(PGC)
UAR123779176(PGC) 123794940 123794941
ELK111142948 111142951 111147505
LLV125098440 125098442 125101959
MPUF101689476 101693498(PGC) 101693781
ORO101370826(PGC) 101377876
EJU114204670(PGC) 114208059
ZCA113927222(PGC)
MLX118000901(PGC) 118018937
NSU110580468(PGB1) 110582128(PGC)
FCA101100053(PGC) 111556254
PYU121026647 121026649 121029436(PGC)
PBG122479442 122479635 122489504(PGC)
LRUF124514459 124516552 124529325
PTG102948554(PGC) 102964203 102965559
PPAD109271603(PGC) 109272037 109272192
AJU106969657 106974058(PGC)
HHV120223472 120223490 120238740(PGC)
BTA514502(PGC)
BOM102288190(PGC)
BIU109577457(PGC)
BBUB102407704(PGC)
CHX102189914(PGC)
OAS101106633(PGC)
ODA120870136(PGC)
CCAD122429554(PGC)
SSC100521201(PGC) 100620249
CFR102523783(PGC)
CBAI105083768(PGC)
CDK105086751(PGC)
VPC102528234(PGC)
BACU103010186(PGC)
LVE103070634(PGC)
OOR101276675(PGC)
DLE111178617(PGC)
PCAD102984618(PGC)
PSIU116761991(PGC)
ECB100066460(PGC)
EPZ103563497(PGC)
EAI106824587(PGC)
MYB102255177(PGC) 102261843
MYD102755151(PGC) 102772869
MMYO118660362(PGC) 118673372
MLF102420032
MNA107536852(PGC) 107545243
PKL118705507(PGC) 118727498
HAI109373549 109382920(PGC)
DRO112302163(PGC)
SHON118993918(PGC)
AJM119055617(PGC)
PDIC114489240(PGB) 114495354(PGC)
PHAS123804647 123821575(PGC)
MMF118621577(PGC) 118637873
RFQ117014974 117020439(PGC)
PALE102877967(PGC) 102881919
PGIG120584944 120596277(PGC)
PVP105288561(PGC)
RAY107501928(PGC)
MJV108389526 108395077(PGC)
TOD119235236 119252449(PGC)
SARA101540464(PGC) 101553208
LAV100665648(PGC) 100675371
TMU101349705 101353827
DNM101412500(PGC) 101429457
MDO100027327 100027345 100027368 100027389 554184(PGC)
GAS123245311(PGC) 123247164 123256217
SHR100917515 100919336 116423409
PCW110204032 110204033 110216792
GGA395690(PGC) 428272(GASTL)
PCOC116236958 116237053
MGP100546064 100546220
CJO107324900 107324901
NMEL110388247 110388248
APLA101792780 101794692
ACYG106045837 106045861
AFUL116498674 116498817
TGU105758893(PGC)
LSR110477157(PGC)
SCAN103823313(PGC)
PMOA120495962(PGC)
OTC121348014(PGC)
PRUF121354004(PGC)
GFR102041764(PGC)
FAB101807666(PGC)
PHI102107379 102107560
PMAJ107214993 107214994
CCW104692528 120411261(PGC)
CBRC103625310 103625369
ETL114070527 114070528
ACHL103808854 103811646(PGC)
FPG101912673 101912850
FCH102048513 106630797
CLV102091578(PGC)
EGZ104125729 104125730
NNI104013154 104013155(PGC)
PLET104619296 104619297
PCRI104029729 104029805(PGC)
ACUN113488821 113488823
TALA104364659 104364660
PADL103919814(PGC) 103919816
AFOR103893624 103893708
ACHC115335172 115335173
HALD104317391(PGC) 104323486
CCRI104158199(PGC) 104161049
CSTI104555981(PGC)
EHS104509363(PGC) 104509365
CMAC104477990 104485872
MUI104546130(PGC) 104546131
FGA104081102 104081103
GSTE104263264 104263265
LDI104343889 104353864(PGC)
MNB103779971
NNT104408214 104408215
DPUB104305349 104305392(PGC)
PGUU104465675 104465676
ACAR104524375 104524376
AVIT104278644 104278645
CVF104289315(PGC) 104289316
AAM106494351 106494352 106494353(PGC)
AROW112961416 112961418 112961419
NPD112959192(PGC) 112959193 112959194
TGT104573317 104573319
DNE112990287 112990305
SCAM104146457 104146458 104146467
ASN102368438 102368697 102368950 102380415
AMJ102562220 102562457 102564094 106736665(PGC)
CPOO109317680 109317781(PGC)
GGN109295112 109295383 109295384 109295385(PGC)
PSS102443428 102443684 102463493 102463918
CMY102941343 102941576 119564418
CPIC101944245 101944509 101944783 101945053
TST117875842 117875843 117875844 117875845
CABI116817833 116818103 116818123 116818131
MRV120404383 120404384 120404490 120404577
ACS100566938 100567135 100567523
PVT110081367 110081374(PGC)
SUND121928825 121929503 121929504 121929505
PBI103055509 103056934 103066093
PMUR107291548 107299949 107299950 107300480
CTIG120306532 120306537 120306542
TSR106540681(PGC)
PGUT117658762
VKO123034113 123034120 123034127 123034134 123034138 123034147
PMUA114598354 114598355 114598356 114598357
ZVI118088671 118089240 118089241 118089242
GJA107107325 107107326 107107327 107107328
STOW125432542 125432543(PGC) 125433372
XLA108704545 108704546 108709103 108709104(pgc.S) 373563(XB964428.S)
XTR100489782 496913 548353(pgc) 594991(pgc) 613072
NPR108804878 108804879 108804887 108804890 108804897 108804900
RTEM120927176 120927177 120927179 120927180 120927181 120927182
BBUF120993348 120993349 120993350 120993351 120993352 120993353 120993728 120993729
BGAR122922647 122922648 122922649 122932317 122932459 122932529
IPU108264667 108264668 108264669 108264670 108266400 108266401 124627001 124628080 124628081 124628082
PHYP113524721 113526108 113534331
SMEO124395392 124395393
TFD113645383 113652781
AMEX103027414(pgc) 103031313 103038890
EEE113577941 113577942 113577957 113580521(pgc)
LCO104940478
CGOB115009416
ELY117262167
EFO125886728
PLEP121949848
SLUC116045622
ECRA117949579
ESP116694704
PFLV114559916
GAT120808852
PPUG119195564
MSAM119893771
ALAT119024692
AOCE111583223 111583917
MCEP125014538
POV109624424(pgc)
HHIP117763167
HSP118109700
LCF108875170
SDU111228596(pgc)
SLAL111671242
XGL120792717
MALB109967483
BSPL114857009
SASA106561235 106561236
STRU115197262 115197264 115197265
OTW112218646 121838767 121840072 121840073
OMY110496598 110496606 110496614
OGO124019375 124035892
ONE115134187 115134188 115134189
SALP112068576 112077499 112078742
SNH120025049 120025060 120025071
CCLU121531982 121531983
ELS105022187 105022190
SFM108924268 108936564 108936565 108936566 108936567
PKI111842453(pgc) 111858572 111859331
AANG118219157
LOC102686226 102693407(pgc)
PSPA121299561 121299841 121299845 121299847 121300146 121322055 121323511
ARUT117396739 117396750 117396758 117407111 117426727 117426791 117432862 117964470
LCM102354616(PGC)
RTP109913610 109919765
RSAN119373383
BMYBM_BM3492(Bma-hrg-7)
LOALOAG_08037
OVIT265_12844
MOREE1B28_002550 E1B28_006882 E1B28_013168
 » show all
Reference
1
  Authors
Ryle, A.P.
  Title
The porcine pepsins and pepsinogens.
  Journal
Methods Enzymol 19:316-336 (1970)
Reference
2
  Authors
Tang, J.
  Title
Gastricsin and pepsin.
  Journal
Methods Enzymol 19:406-421 (1970)
Reference
3  [PMID:6795036]
  Authors
Foltmann B.
  Title
Gastric proteinases--structure, function, evolution and mechanism of action.
  Journal
Essays Biochem 17:52-84 (1981)
Reference
4  [PMID:6816595]
  Authors
Foltmann B, Jensen AL.
  Title
Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.
  Journal
Eur J Biochem 128:63-70 (1982)
DOI:10.1111/j.1432-1033.1982.tb06931.x
  Sequence
[hsa:5225]
Reference
5  [PMID:6800788]
  Authors
Martin P, Trieu-Cuot P, Collin JC, Ribadeau Dumas B.
  Title
Purification and characterization of bovine gastricsin.
  Journal
Eur J Biochem 122:31-9 (1982)
DOI:10.1111/j.1432-1033.1982.tb05844.x
Reference
6  [PMID:6432332]
  Authors
Reid WA, Vongsorasak L, Svasti J, Valler MJ, Kay J.
  Title
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.
  Journal
Cell Tissue Res 236:597-600 (1984)
DOI:10.1007/bf00217228
Reference
7  [PMID:3335549]
  Authors
Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K.
  Title
Primary structure of human pepsinogen C gene.
  Journal
J Biol Chem 263:1382-5 (1988)
  Sequence
[hsa:5225]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.3
IUBMB Enzyme Nomenclature: 3.4.23.3
ExPASy - ENZYME nomenclature database: 3.4.23.3
BRENDA, the Enzyme Database: 3.4.23.3
CAS: 9012-71-9

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