KEGG   ENZYME: 3.4.23.4Help
Entry
EC 3.4.23.4                 Enzyme                                 

Name
chymosin;
rennin (but this should be avoided since it leads to confusion with renin)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105!Met-Ala bond in kappa-chain of casein
Comment
Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family)
History
EC 3.4.23.4 created 1961 as EC 3.4.4.3, transferred 1972 to EC 3.4.23.4, modified 1986
Orthology
K01378  chymosin
Genes
GGO: 101141938
NLE: 100595848
MCC: 100425303
MCF: 102124530
CSAB: 103224246
RRO: 104680341
RBB: 108528004
CJC: 100411198(CYM)
SBQ: 101040593
MMU: 229697(Cym)
RNO: 56825(Cym)
CGE: 100759177
NGI: 103747813
CCAN: 109702561
OCU: 100354542
TUP: 102496533
CFA: 100856000
AML: 100478363
UMR: 103675019
ORO: 101386303
FCA: 101083355
PTG: 102969814
AJU: 106978180
BTA: 529879(CYM)
BOM: 102277564
BIU: 109557034
PHD: 102343511
CHX: 100861166(CYM)
OAS: 443399(CYM)
SSC: 396864(CYM)
CFR: 102515505
CDK: 105085668
BACU: 103001873
LVE: 103074375
OOR: 101282938
MYB: 102241708
MYD: 102769611
HAI: 109371566
RSS: 109446802
PALE: 102896975
LAV: 100669186
TMU: 101354650
MDO: 100030263
SHR: 100932628
OAA: 100077212
GGA: 395926(PGA3)
MGP: 100539842
CJO: 107324766
APLA: 101803733
ACYG: 106048442
TGU: 100225946
GFR: 102031903
PHI: 102113955
PMAJ: 107214827
CCAE: 111939876
CCW: 104692428
FPG: 101920610
FCH: 102052516
EGZ: 104131419
AAM: 106484398
ACS: 100555068
PBI: 103048622
GJA: 107106443
 » show all
Taxonomy
Reference
1  [PMID:5330666]
  Authors
Foltmann B.
  Title
A review on prorennin and rennin.
  Journal
C R Trav Lab Carlsberg 35:143-231 (1966)
Reference
2  [PMID:6283469]
  Authors
Harris TJ, Lowe PA, Lyons A, Thomas PG, Eaton MA, Millican TA, Patel TP, Bose CC, Carey NH, Doel MT.
  Title
Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.
  Journal
Nucleic Acids Res 10:2177-87 (1982)
DOI:10.1093/nar/10.7.2177
  Sequence
[bta:529879]
Reference
3  [PMID:3128264]
  Authors
Visser S, Slangen CJ, van Rooijen PJ.
  Title
Peptide substrates for chymosin (rennin). Interaction sites in kappa-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft.
  Journal
Biochem J 244:553-8 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.4
IUBMB Enzyme Nomenclature: 3.4.23.4
ExPASy - ENZYME nomenclature database: 3.4.23.4
BRENDA, the Enzyme Database: 3.4.23.4
CAS: 9001-98-3

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