KEGG   ENZYME: 3.4.23.41Help
Entry
EC 3.4.23.41                Enzyme                                 

Name
yapsin 1;
yeast aspartic protease 3;
Yap3 gene product (Saccharomyces cerevisiae)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions
Comment
In peptidase family A1 of pepsin, and weakly inhibited by pepstatin. Can partially substitute for kexin in a deficient strain of yeast. The homologous product of the Mkc7 gene (Saccharomyces cerevisiae) has similar catalytic activity and has been termed yapsin 2 [2]
History
EC 3.4.23.41 created 2000
Orthology
K06009  yapsin 1/2
Genes
SCE: YDR144C(MKC7) YLR120C(YPS1)
AGO: AGOS_AGL192W
ERC: Ecym_4251
KLA: KLLA0_E04049g
KMX: KLMA_20534(YPS1)
LTH: KLTH0G12386g
VPO: Kpol_543p61
ZRO: ZYRO0E02266g ZYRO0F10230g ZYRO0F10252g ZYRO0F10274g ZYRO0F10296g ZYRO0F10318g ZYRO0G02904g
CGR: CAGL0M04191g
NCS: NCAS_0B03560(NCAS0B03560) NCAS_0C03300(NCAS0C03300)
NDI: NDAI_0G02620(NDAI0G02620) NDAI_0J01030(NDAI0J01030)
TPF: TPHA_0A01580(TPHA0A01580)
TBL: TBLA_0H01290(TBLA0H01290)
TDL: TDEL_0F04450(TDEL0F04450)
KAF: KAFR_0B05710(KAFR0B05710) KAFR_0E03940(KAFR0E03940) KAFR_0H02300(KAFR0H02300)
CAUR: QG37_08133
SLB: AWJ20_1769(YPS1)
 » show all
Taxonomy
Reference
1  [PMID:8626758]
  Authors
Cawley NX, Chen HC, Beinfeld MC, Loh YP.
  Title
Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3.
  Journal
J Biol Chem 271:4168-76 (1996)
DOI:10.1074/jbc.271.8.4168
Reference
2
  Authors
Fuller, R.S.
  Title
Yapsin 2.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 908-909.
Reference
3  [PMID:9485427]
  Authors
Olsen V, Guruprasad K, Cawley NX, Chen HC, Blundell TL, Loh YP.
  Title
Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling.
  Journal
Biochemistry 37:2768-77 (1998)
DOI:10.1021/bi9724826
  Sequence
[sce:YLR120C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.41
IUBMB Enzyme Nomenclature: 3.4.23.41
ExPASy - ENZYME nomenclature database: 3.4.23.41
BRENDA, the Enzyme Database: 3.4.23.41
CAS: 205132-58-7

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