KEGG   ENZYME: 3.4.23.47Help
Entry
EC 3.4.23.47                Enzyme                                 

Name
HIV-2 retropepsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase for which the P1 residue is preferably hydrophobic
Comment
In peptidase family A2. Responsible for the post-translational processing of the human immunodeficiency virus polyprotein.
History
EC 3.4.23.47 created 2003
Orthology
K22599  HIV protease
Reference
1  [PMID:2015912]
  Authors
Tozser J, Blaha I, Copeland TD, Wondrak EM, Oroszlan S.
  Title
Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins.
  Journal
FEBS Lett 281:77-80 (1991)
DOI:10.1016/0014-5793(91)80362-7
Reference
2  [PMID:7929352]
  Authors
Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC.
  Title
Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
  Journal
J Biol Chem 269:26344-8 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.47
IUBMB Enzyme Nomenclature: 3.4.23.47
ExPASy - ENZYME nomenclature database: 3.4.23.47
BRENDA, the Enzyme Database: 3.4.23.47
CAS: 144114-21-6

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