KEGG   ENZYME: 3.4.23.48Help
Entry
EC 3.4.23.48                Enzyme                                 

Name
plasminogen activator Pla
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Converts human Glu-plasminogen to plasmin by cleaving the Arg560!Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins
Comment
In peptidase family A26. From the bacterium Yersinia pestis that causes plague.
History
EC 3.4.23.48 created 2003
Orthology
K08566  plasminogen activator
Genes
EMA: C1192_04795
ENT: Ent638_1900
ENC: ECL_02114
EEC: EcWSU1_02066(pla)
ENL: A3UG_10560
ECLG: EC036_20370
ELG: BH714_06585
ESA: ESA_pESA3p05434
CSZ: CSSP291_20538
CUI: AFK65_20100
KPE: KPK_A0239(ompT)
KOX: KOX_19050
KOE: A225_2692
YPE: YPPCP1.07(pla)
YPH: YPC_4887(pla)
YPM: YP_pPCP08(pla)
YPZ: YPZ3_pPCP0007(pla)
YPD: YPD4_pPCP0007(pla)
YPX: YPD8_pPCP0007(pla)
YPW: CH59_4484(pla)
YPJ: CH55_4381(pla)
YPV: BZ15_4409(pla)
YPL: CH46_4426(pla)
SERF: L085_07440
PEC: W5S_1274
EPY: EpC_pEp360230(plaA)
EPR: EPYR_03992(ompT)
ERJ: EJP617_A170(plaA)
EGE: EM595_2975(pla)
PVA: Pvag_pPag30480(pgtE)
XDO: XDD1_1985(pla)
LLG: 44548918_00683(pla)
PLG: NCTC10937_01775(pla)
OAH: DR92_1102
 » show all
Taxonomy
Reference
1  [PMID:11401715]
  Authors
Kukkonen M, Lahteenmaki K, Suomalainen M, Kalkkinen N, Emody L, Lang H, Korhonen TK.
  Title
Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of Yersinia pestis.
  Journal
Mol Microbiol 40:1097-111 (2001)
DOI:10.1046/j.1365-2958.2001.02451.x
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.48
IUBMB Enzyme Nomenclature: 3.4.23.48
ExPASy - ENZYME nomenclature database: 3.4.23.48
BRENDA, the Enzyme Database: 3.4.23.48
CAS: 101028-08-4

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