KEGG   ENZYME: 3.4.23.52Help
Entry
EC 3.4.23.52                Enzyme                                 

Name
preflagellin peptidase;
FlaK
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves the signal peptide of 3 to 12 amino acids from the N-terminal of preflagellin, usually at Arg-Gly! or Lys-Gly!, to release flagellin.
Comment
An aspartic peptidase from Archaea but not bacteria. In peptidase family A24 (type IV prepilin peptidase family).
History
EC 3.4.23.52 created 2011
Orthology
K07991  archaeal preflagellin peptidase FlaK
Genes
CDRK: B9W14_16060
MJA: MJ_0835.2 MJ_0902 MJ_1282.1
MFE: Mefer_0085 Mefer_0927 Mefer_1204
MVU: Metvu_0103 Metvu_0136 Metvu_0507
MFS: MFS40622_0342 MFS40622_1256 MFS40622_1326
MIF: Metin_0787 Metin_1346
MJH: JH146_1005 JH146_1067
MIG: Metig_0976
MMP: MMP0232 MMP0555(flaK)
MMQ: MmarC5_1052 MmarC5_1441
MTH: MTH_421
METC: MTCT_0362
METE: tca_00387
MST: Msp_0452
MSI: Msm_0146
MRU: mru_1234
MEB: Abm4_0821
MMIL: sm9_0904
MEYE: TL18_05760
MOL: YLM1_0666
METH: MBMB1_1175
MFC: BRM9_1380
MCUB: MCBB_1078
MFV: Mfer_0424
AFU: AF_0936
FPL: Ferp_0061
GAC: GACE_1897
GAH: GAH_00760
MEAR: Mpt1_c00800(flaK)
MARC: AR505_0164
ABI: Aboo_1309
PHO: PH0446(PH0446)
PAB: PAB1309
PFU: PF0471
PFI: PFC_01470
PYN: PNA2_1078
PYS: Py04_0633
TKO: TK0053
TON: TON_1174
TGA: TGAM_0998(pilD)
TSI: TSIB_1091
THE: GQS_09705
THA: TAM4_883
THM: CL1_1529
TLT: OCC_07586
THS: TES1_1258
TNU: BD01_1137
TEU: TEU_11575
PPAC: PAP_04570
MBAR: MSBR2_1968
MBAK: MSBR3_1940
MMA: MM_1678
MMAC: MSMAC_1441
MTHE: MSTHC_1229
MTHR: MSTHT_2055
MBU: Mbur_0062
MMET: MCMEM_0643
MMH: Mmah_1223
MPY: Mpsy_1395
MHU: Mhun_2921
MLA: Mlab_0122
MEMA: MMAB1_0328(flaK)
MPI: Mpet_1817
MBN: Mboo_1915
MPL: Mpal_0687
MPD: MCP_1254
MEZ: Mtc_1760
RCI: RCIX2250
HAL: VNG_2285C
HSL: OE_4201R(pibD)
HHB: Hhub_3593(pibD)
HALH: HTSR_0082
HHSR: HSR6_0081
HSU: HLASF_0126(flaK)
HSF: HLASA_0126(flaK)
HMA: rrnAC2525
HHI: HAH_2955
NPH: NP_1276A(pibD)
NMO: Nmlp_1230(pibD)
HUT: Huta_1780
HTI: HTIA_1331
HMU: Hmuk_0855
HWA: HQ_1021A(pibD)
HWC: Hqrw_1023(pibD)
HVO: HVO_2993(pibD)
HME: HFX_2987(pppA)
HLA: Hlac_2136
HTU: Htur_0098
NMG: Nmag_1752(pibD)
NAT: NJ7G_0536
SALI: L593_08685
SMR: Smar_0975
IHO: Igni_1405
IIS: EYM_05410
DKA: DKAM_1214
TAG: Tagg_0764
IAG: Igag_1461
HBU: Hbut_0969
STO: STK_22580(pibD)
SSO: SSO0131
SOL: Ssol_1106
SSOA: SULA_1143
SSOL: SULB_1144
SSOF: SULC_1142
SAI: Saci_0139
SID: M164_2002
SII: LD85_2259
SIH: SiH_1940
SIR: SiRe_1868
SIC: SiL_1848
MSE: Msed_2090
MCN: Mcup_0199
AHO: Ahos_0481
PAI: PAE1599
PIS: Pisl_1644
PCL: Pcal_0607
PAS: Pars_2129
PYR: P186_2874
POG: Pogu_2758
TNE: Tneu_0668
CMA: Cmaq_1769
TUZ: TUZN_0649
TTN: TTX_0979
VDI: Vdis_0551
VMO: VMUT_1226
TPE: Tpen_0879
NIN: NADRNF5_1191(flaK)
NGA: Ngar_c06790(flaK1) Ngar_c08050(flaK2) Ngar_c19450(flaK3)
NVN: NVIE_009600(flaK1) NVIE_010080(flaK2)
NEV: NTE_02368
NDV: NDEV_0978 NDEV_1020(flaK)
MARH: Mia14_0570
KCR: Kcr_0394
 » show all
Taxonomy
Reference
1  [PMID:11934494]
  Authors
Bardy SL, Jarrell KF
  Title
FlaK of the archaeon Methanococcus maripaludis possesses preflagellin peptidase activity.
  Journal
FEMS Microbiol Lett 208:53-9 (2002)
DOI:10.1111/j.1574-6968.2002.tb11060.x
  Sequence
[mmp:MMP0555]
Reference
2  [PMID:19717585]
  Authors
Ng SY, VanDyke DJ, Chaban B, Wu J, Nosaka Y, Aizawa S, Jarrell KF
  Title
Different minimal signal peptide lengths recognized by the archaeal prepilin-like peptidases FlaK and PibD.
  Journal
J Bacteriol 191:6732-40 (2009)
DOI:10.1128/JB.00673-09
Reference
3  [PMID:21765428]
  Authors
Hu J, Xue Y, Lee S, Ha Y
  Title
The crystal structure of GXGD membrane protease FlaK.
  Journal
Nature 475:528-31 (2011)
DOI:10.1038/nature10218
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.52
IUBMB Enzyme Nomenclature: 3.4.23.52
ExPASy - ENZYME nomenclature database: 3.4.23.52
BRENDA, the Enzyme Database: 3.4.23.52

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