KEGG   ENZYME: 3.4.24.12Help
Entry
EC 3.4.24.12                Enzyme                                 

Name
envelysin;
sea-urchin-hatching proteinase;
hatching enzyme;
chorionase;
chorion-digesting proteinase;
chymostrypsin;
sea urchin embryo hatching enzyme
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins of the fertilization envelope and dimethylcasein
Comment
A glycoprotein from various members of the class Echinoidea. Extracellular enzyme requiring Ca2+. In peptidase family M10 (interstitial collagenase family)
History
EC 3.4.24.12 created 1978
Orthology
K19957  envelysin
Genes
SPU: 578408(HE) 752524
Taxonomy
Reference
1  [PMID:1012003]
  Authors
Barrett D, Edwards BF.
  Title
Hatching enzyme of the sea urchin Strongylocentrotus purpuratus.
  Journal
Methods Enzymol 45:354-73 (1976)
DOI:10.1016/S0076-6879(76)45032-2
Reference
2  [PMID:2925668]
  Authors
Lepage T, Gache C.
  Title
Purification and characterization of the sea urchin embryo hatching enzyme.
  Journal
J Biol Chem 264:4787-93 (1989)
Reference
3  [PMID:2167841]
  Authors
Lepage T, Gache C.
  Title
Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo.
  Journal
EMBO J 9:3003-12 (1990)
  Sequence
Reference
4  [PMID:1711895]
  Authors
Nomura K, Tanaka H, Kikkawa Y, Yamaguchi M, Suzuki N.
  Title
The specificity of sea urchin hatching enzyme (envelysin) places it in the mammalian matrix metalloproteinase family.
  Journal
Biochemistry 30:6115-23 (1991)
  Sequence
[spu:752524]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.12
IUBMB Enzyme Nomenclature: 3.4.24.12
ExPASy - ENZYME nomenclature database: 3.4.24.12
BRENDA, the Enzyme Database: 3.4.24.12
CAS: 50812-13-0

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