KEGG   ENZYME: 3.4.24.14Help
Entry
EC 3.4.24.14                Enzyme                                 

Name
procollagen N-endopeptidase;
procollagen N-terminal peptidase;
procollagen aminopeptidase;
aminoprocollagen peptidase;
aminoterminal procollagen peptidase;
procollagen aminoterminal protease;
procollagen N-terminal proteinase;
type I/II procollagen N-proteinase;
type III procollagen
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves the N-propeptide of collagen chain alpha1(I) at Pro!Gln and of alpha1(II) and alpha2(I) at Ala!Gln
Comment
Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family)
History
EC 3.4.24.14 created 1984
Orthology
K08618  a disintegrin and metalloproteinase with thrombospondin motifs 2
Genes
HSA: 9509(ADAMTS2)
PTR: 462325(ADAMTS2)
PPS: 100979430(ADAMTS2)
GGO: 101142866(ADAMTS2)
PON: 100447800(ADAMTS2)
NLE: 100589584(ADAMTS2)
MCC: 713532(ADAMTS2)
MCF: 102133312(ADAMTS2)
CSAB: 103245099(ADAMTS2)
RRO: 104676210(ADAMTS2)
RBB: 108539415(ADAMTS2)
CJC: 100395899(ADAMTS2)
SBQ: 101039904(ADAMTS2)
MMU: 216725(Adamts2)
RNO: 287899(Adamts2)
CGE: 100769264(Adamts2)
NGI: 103749380(Adamts2)
HGL: 101711463(Adamts2)
CCAN: 109688447
OCU: 100345799(ADAMTS2)
TUP: 102485420(ADAMTS2)
CFA: 481453(ADAMTS2)
AML: 100470520(ADAMTS2)
UMR: 103680011(ADAMTS2)
ORO: 101380933(ADAMTS2)
FCA: 101096945(ADAMTS2)
PTG: 102955026(ADAMTS2)
AJU: 106970137(ADAMTS2)
BTA: 282401(ADAMTS2)
BOM: 102267134(ADAMTS2)
BIU: 109561344(ADAMTS2)
PHD: 102314938(ADAMTS2)
CHX: 102182397(ADAMTS2)
OAS: 101120574(ADAMTS2)
SSC: 100521434(ADAMTS2)
CFR: 102506510(ADAMTS2)
CDK: 105100636(ADAMTS2)
BACU: 103012078(ADAMTS2)
LVE: 103071192(ADAMTS2)
OOR: 101284632(ADAMTS2) 105748795
ECB: 100630632(ADAMTS2)
EPZ: 103559965(ADAMTS2)
EAI: 106843705(ADAMTS2)
MYB: 102255495(ADAMTS2)
MYD: 102760485(ADAMTS2)
HAI: 109392749(ADAMTS2)
RSS: 109435679 109439450(ADAMTS2)
PALE: 102883520(ADAMTS2)
LAV: 100674486(ADAMTS2)
TMU: 101348900
MDO: 100029340(ADAMTS2)
SHR: 100920081(ADAMTS2)
OAA: 100074059(ADAMTS2)
GGA: 416291(ADAMTS2)
MGP: 100538388(ADAMTS2)
CJO: 107320100(ADAMTS2)
APLA: 101799569
ACYG: 106032808(ADAMTS2)
TGU: 100224296(ADAMTS2)
GFR: 102038616(ADAMTS2)
FAB: 101819965(ADAMTS2)
PHI: 102107776(ADAMTS2)
PMAJ: 107210556(ADAMTS2)
CCAE: 111935404(ADAMTS2)
CCW: 104689702(ADAMTS2)
FPG: 101917429(ADAMTS2)
FCH: 102056156(ADAMTS2)
CLV: 102084652(ADAMTS2)
EGZ: 104128442(ADAMTS2)
AAM: 106493433(ADAMTS2)
ASN: 102383052(ADAMTS2)
AMJ: 102569690(ADAMTS2)
CMY: 102943314(ADAMTS2)
CPIC: 101950216(ADAMTS2)
ACS: 100557740(adamts2)
PVT: 110073478(ADAMTS2)
GJA: 107123236(ADAMTS2)
XLA: 108710899(adamts2.L) 108713291(adamts2.S)
XTR: 100492431(adamts2)
NPR: 108798945
DRE: 571682(adamts2)
NCC: 104949504
LCM: 102351758(ADAMTS2)
CMK: 103186476(adamts2)
PCF: 106784434
ADF: 107356636
 » show all
Taxonomy
Reference
1  [PMID:4204204]
  Authors
Kohn LD, Isersky C, Zupnik J, Lenaers A, Lee G, Lapiere CM.
  Title
Calf tendon procollagen peptidase: its purification and endopeptidase mode of action.
  Journal
Proc Natl Acad Sci U S A 71:40-4 (1974)
DOI:10.1073/pnas.71.1.40
Reference
2  [PMID:2500439]
  Authors
Hojima Y, McKenzie JA, van der Rest M, Prockop DJ.
  Title
Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides.
  Journal
J Biol Chem 264:11336-45 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.14
IUBMB Enzyme Nomenclature: 3.4.24.14
ExPASy - ENZYME nomenclature database: 3.4.24.14
BRENDA, the Enzyme Database: 3.4.24.14
CAS: 68651-94-5

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