KEGG   ENZYME: 3.4.24.15Help
Entry
EC 3.4.24.15                Enzyme                                 

Name
thimet oligopeptidase;
Pz-peptidase;
soluble metalloendopeptidase;
endo-oligopeptidase A;
tissue-endopeptidase degrading collagenase-synthetic-substrate
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues
Comment
Thiol compounds activate at low concentrations. Type example of peptidase family M3.
History
EC 3.4.24.15 created 1984 (EC 3.4.22.19 created 1989 and EC 3.4.99.31 created 1978 both incorporated 1992)
Orthology
K01392  thimet oligopeptidase
Genes
HSA: 7064(THOP1)
PTR: 750162(THOP1)
PPS: 100985112(THOP1)
GGO: 101143234(THOP1)
PON: 100455971(THOP1)
NLE: 100583449(THOP1) 105739073
MCC: 721578(THOP1)
MCF: 102117812(THOP1)
CSAB: 103233658(THOP1)
RRO: 104665465(THOP1)
RBB: 108537535(THOP1)
CJC: 100385317(THOP1)
SBQ: 101028985(THOP1)
MMU: 50492(Thop1)
RNO: 64517(Thop1)
CGE: 100764672(Thop1)
NGI: 103737278(Thop1)
HGL: 101714143(Thop1)
CCAN: 109691048(Thop1) 109702423
TUP: 102500342(THOP1)
CFA: 476748(THOP1)
AML: 100471700(THOP1)
UMR: 103681807(THOP1)
ORO: 101362401(THOP1)
FCA: 101083746(THOP1)
PTG: 102964477(THOP1)
AJU: 106982145(THOP1)
BTA: 510889(THOP1)
BOM: 102265369(THOP1)
BIU: 109561783(THOP1)
PHD: 102322671(THOP1) 102335160
CHX: 102178165(THOP1)
OAS: 101119557(THOP1)
SSC: 397442(THOP1)
CFR: 102508107(THOP1)
CDK: 105106052(THOP1)
LVE: 103090843(THOP1)
OOR: 101287363(THOP1)
ECB: 100059667(THOP1)
EPZ: 103540477(THOP1)
EAI: 106834154(THOP1)
MYB: 102262534(THOP1)
MYD: 102774039(THOP1)
HAI: 109390675(THOP1)
RSS: 109454000(THOP1)
PALE: 102886786(THOP1)
TMU: 101346830
MDO: 100020499(THOP1)
SHR: 100924623(THOP1)
OAA: 100076730
GGA: 426398(THOP1)
MGP: 100545913(THOP1)
CJO: 107325439(THOP1)
APLA: 101799830 101804753(THOP1)
ACYG: 106048201(THOP1)
TGU: 100231983(THOP1)
GFR: 102032301(THOP1)
FAB: 101805763(THOP1)
PHI: 102110662(THOP1)
PMAJ: 107215455(THOP1)
CCAE: 111940251(THOP1)
CCW: 104697073(THOP1)
FPG: 101913462(THOP1)
FCH: 102053721(THOP1)
CLV: 102095097(THOP1)
EGZ: 104132299(THOP1)
AAM: 106486695(THOP1)
ASN: 102383675(THOP1)
AMJ: 102558370(THOP1)
PSS: 102457370(THOP1)
CMY: 102940710(THOP1)
CPIC: 101943510(THOP1)
PVT: 110079254(THOP1)
PBI: 103051765(THOP1)
GJA: 107105512(THOP1)
XLA: 108706839(thop1.S) 397806(thop1.L)
XTR: 779863(thop1)
NPR: 108802730
DRE: 436628(thop1)
IPU: 108271294(thop1) 108276763(nln)
AMEX: 103022190(nln) 103038939(thop1)
TRU: 101068340(nln) 101069017(thop1)
LCO: 104935746(thop1) 104937376
MZE: 101464999(thop1) 101467989
OLA: 101157763(thop1) 101172348(nln)
XMA: 102222331(thop1) 111606537
PRET: 103463257(thop1)
NFU: 107374865(nln) 107395897(thop1)
KMR: 108228871(thop1)
CSEM: 103396631(thop1)
SDU: 111231825(thop1) 111239054
HCQ: 109506833(thop1) 109526047
BPEC: 110157536 110167856(thop1)
MALB: 109965204(thop1) 109969773
SASA: 100194867(mepd) 106613599(MEPD)
ELS: 105011365(thop1)
SFM: 108929954(nln) 108935234
LCM: 102357708(THOP1)
CMK: 103181955(thop1)
CIN: 100183579
APLC: 110987267
SKO: 100373471
FCD: 110858459
MYI: 110466585
OBI: 106883272
LAK: 106165041
ADF: 107338969
HMG: 100212290
ATH: AT1G67690
CRB: 17894312
THJ: 104825527
CPAP: 110811640
CIT: 102612794
TCC: 18609680
GRA: 105794549
DZI: 111282553
EGR: 104433638
VRA: 106755630
VAR: 108327003
CCAJ: 109809646
CAM: 101492891
LJA: Lj2g3v1402690.2(Lj2g3v1402690.2)
ADU: 107468942
AIP: 107623713
LANG: 109327233
FVE: 101295009
PPER: 18789331
PMUM: 103321960
PAVI: 110753096
PXB: 103949886
ZJU: 107428397
CSV: 101203244
CMO: 103487749
MCHA: 111004893
CMAX: 111491781
CMOS: 111462816
CPEP: 111805736
RCU: 8278432
JCU: 105644751
HBR: 110640451
POP: 7460043
JRE: 108982025
VVI: 100251085
SLY: 101244701
SPEN: 107030536
SOT: 102581011
CANN: 107878381
NTO: 104101862
INI: 109172014
SIND: 105168364
OEU: 111401948
HAN: 110895102
LSV: 111887622
CCAV: 112524158
DCR: 108197056
BVG: 104897646
SOE: 110793856
NNU: 104591627
OSA: 4325012
DOSA: Os01t0902200-01(Os01g0902200)
OBR: 102721983
BDI: 100821906
ATS: 109754044(LOC109754044)
SBI: 8056125
ZMA: 100280152(si683006e11)
SITA: 101785951
EGU: 105053005
MUS: 103994127
DCT: 110099372
PEQ: 110021067
AOF: 109836686
ATR: 18441855
DFA: DFA_04384
SPAR: SPRG_12685
PSUW: WQ53_10275
ABN: AB57_1834
ABX: ABK1_2095
ABH: M3Q_1989
ABAD: ABD1_15970
ABAZ: P795_9225
ABAU: IX87_18875
ABAA: IX88_09965
ACC: BDGL_000980(thoP1)
CJA: CJA_2059
SDE: Sde_2026
TBN: TBH_C0772
MPT: Mpe_A1779
CFU: CFU_3179
CARE: LT85_1318
OFO: BRW83_0121(prlC_1)
BBAG: E1O_22950
DEU: DBW_3398(prlC)
ADE: Adeh_0397
CCX: COCOR_00293(prlC) COCOR_06341(prlC1)
SCL: sce4462(prlC1)
HOH: Hoch_5061
DPB: BABL1_gene_25(prlC)
ADO: A6F68_02348(prlC)
MTS: MTES_0996
LMOI: VV02_11660
CFI: Celf_0358
NCA: Noca_4613
NDK: I601_3548(prlC)
PSIM: KR76_26405
OBG: Verru16b_00587(prlC)
ACA: ACP_2228
ABAS: ACPOL_1354
SUS: Acid_7278
EMI: Emin_1536
 » show all
Taxonomy
Reference
1  [PMID:3244563]
  Authors
Cicilini MA, Ribeiro MJ, de Oliveira EB, Mortara RA, de Camargo AC.
  Title
Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides.
  Journal
Peptides 9:945-55 (1988)
DOI:10.1016/0196-9781(88)90072-1
Reference
2  [PMID:2803255]
  Authors
Orlowski M, Reznik S, Ayala J, Pierotti AR.
  Title
Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides.
  Journal
Biochem J 261:951-8 (1989)
Reference
3  [PMID:2123097]
  Authors
Barrett AJ, Brown MA.
  Title
Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase.
  Journal
Biochem J 271:701-6 (1990)
Reference
4  [PMID:2261476]
  Authors
Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL.
  Title
Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.
  Journal
Biochemistry 29:10323-9 (1990)
  Sequence
[rno:64517]
Reference
5  [PMID:2185743]
  Authors
Tisljar U, Barrett AJ.
  Title
Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit.
  Journal
Biochem J 267:531-3 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.15
IUBMB Enzyme Nomenclature: 3.4.24.15
ExPASy - ENZYME nomenclature database: 3.4.24.15
BRENDA, the Enzyme Database: 3.4.24.15
CAS: 110639-28-6

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