Entry
Name
thimet oligopeptidase;
Pz-peptidase;
soluble metalloendopeptidase;
endo-oligopeptidase A;
tissue-endopeptidase degrading collagenase-synthetic-substrate
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5-15 residues
Comment
Thiol compounds activate at low concentrations. Type example of peptidase family M3.
History
EC 3.4.24.15 created 1984 (EC 3.4.22.19 created 1989 and EC 3.4.99.31 created 1978 both incorporated 1992)
Orthology
Genes
CCAN : 109691048(Thop1) 109702423
BMUS : 118892444(THOP1) 118892597
PSIU : 116751758(THOP1) 116761195
XLA : 108706839(thop1.S) 397806(thop1.L)
SRX : 107726548 107730481 107751012
CAUA : 113054995 113069380
CGIB : 127968090 128022613
MASI : 127426443 127427641
MSAM : 119888385 119888386
LCF : 108882357(thop1) 108892667
SASA : 100194867(mepd) 106613599(MEPD)
STRU : 115151639 115158073
OGO : 123997264(thop1) 123997863
SALP : 111952854 111975950
CCLU : 121533688 121576477(thop1)
ARUT : 117401455 117966344
CPLA : 122557939 122565420
LPIC : 129271765 129271768
BCOO : 119080155 119080156
RSAN : 119405166 119405167
CSCU : 111634737 111637553 111642625
SMM : Smp_029470 Smp_029500
SHX : MS3_00004895(THOP1_1) MS3_00004897(THOP1_2)
CSAT : 104704713 104750568 104787784
BNA : 106353963 106410390 106436805 106454291
LJA : Lj2g3v1402690.2(Lj2g3v1402690.2)
MSYL : 126597794 126608737
PSOM : 113298209 113302654
DOSA : Os01t0902200-01(Os01g0902200)
TAES : 123062821 123071663 123080010
PVIR : 120676599 120708956
SMO : SELMODRAFT_113618 SELMODRAFT_164651
» show all
Taxonomy
Reference
Authors
Cicilini MA, Ribeiro MJ, de Oliveira EB, Mortara RA, de Camargo AC.
Title
Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides.
Journal
Reference
Authors
Orlowski M, Reznik S, Ayala J, Pierotti AR.
Title
Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides.
Journal
Reference
Authors
Barrett AJ, Brown MA.
Title
Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase.
Journal
Reference
Authors
Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL
Title
Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.
Journal
Sequence
Reference
Authors
Tisljar U, Barrett AJ.
Title
Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.15