KEGG   ENZYME: 3.4.24.17Help
Entry
EC 3.4.24.17                Enzyme                                 

Name
stromelysin 1;
matrix metalloproteinase 3;
proteoglycanase;
collagenase activating protein;
procollagenase activator;
transin;
MMP-3;
neutral proteoglycanase;
stromelysin;
collagen-activating protein
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage where P1', P2' and P3' are hydrophobic residues
Comment
An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family)
History
EC 3.4.24.17 created 1990
Orthology
K01394  matrix metalloproteinase-3 (stromelysin 1, progelatinase)
Genes
HSA: 4314(MMP3)
PTR: 451511(MMP3)
PPS: 100995831(MMP3)
GGO: 101131989(MMP3)
PON: 100461529(MMP3)
NLE: 100583082(MMP3)
MCC: 703762(MMP3)
MCF: 102142651(MMP3)
CSAB: 103248344(MMP3)
RRO: 104674668(MMP3)
RBB: 108514072(MMP3)
CJC: 100396218(MMP3)
SBQ: 101051562(MMP3)
MMU: 17392(Mmp3)
RNO: 171045(Mmp3)
CGE: 100754565
NGI: 103731587(Mmp3)
HGL: 101702569 101716622(Mmp3)
CCAN: 109689285
OCU: 100009111(MMP3)
TUP: 102489067(MMP3)
CFA: 403445(MMP3)
AML: 100478420
ORO: 101368994(MMP3)
FCA: 101081492
PTG: 102970292
AJU: 106976485(MMP3)
BTA: 281309(MMP3)
BOM: 102288330(MMP3) 106701016
BIU: 109569248
PHD: 102338564(MMP3)
CHX: 102170893(MMP3)
OAS: 101118895(MMP3)
SSC: 396769(MMP3)
CFR: 102516794(MMP3)
CDK: 105087168
BACU: 103010042(MMP3)
LVE: 103089307(MMP3)
OOR: 101270746
ECB: 100034195(MMP3)
EPZ: 103552637(MMP3)
EAI: 106843118(MMP3)
MYD: 102770528(MMP3)
RSS: 109439599
PALE: 102886139
LAV: 100660303
TMU: 101341271
MDO: 100011059(MMP3)
SHR: 100934169
OAA: 100077197
GGA: 418981(MMP10) 428086(MMP3)
APLA: 101794349(MMP3) 101798488
FPG: 101924760(MMP3)
FCH: 102050939(MMP3)
CMY: 102940374 102940592(MMP3)
CPIC: 101931780 101932067(MMP3)
IPU: 108276913
AMEX: 103038016
TRU: 101068697(MMPF20L)
LCO: 104930317
CSEM: 103377668
LCF: 108893128
HCQ: 109512887
LCM: 102363127
 » show all
Taxonomy
Reference
1  [PMID:2995374]
  Authors
Chin JR, Murphy G, Werb Z.
  Title
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.
  Journal
J Biol Chem 260:12367-76 (1985)
Reference
2  [PMID:3095317]
  Authors
Okada Y, Nagase H, Harris ED Jr.
  Title
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.
  Journal
J Biol Chem 261:14245-55 (1986)
Reference
3  [PMID:2197998]
  Authors
Docherty AJ, Murphy G.
  Title
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
  Journal
Ann Rheum Dis 49:469-79 (1990)
Reference
4  [PMID:2165861]
  Authors
Emonard H, Grimaud JA.
  Title
Matrix metalloproteinases. A review.
  Journal
Cell Mol Biol 36:131-53 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.17
IUBMB Enzyme Nomenclature: 3.4.24.17
ExPASy - ENZYME nomenclature database: 3.4.24.17
BRENDA, the Enzyme Database: 3.4.24.17
CAS: 79955-99-0

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