KEGG   ENZYME: 3.4.24.18Help
Entry
EC 3.4.24.18                Enzyme                                 

Name
meprin A;
endopeptidase-2;
meprin-a;
meprin;
N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase;
PABA-peptide hydrolase;
PPH
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues
Comment
A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts. Differences from neprilysin (EC 3.4.24.11 (astacin family). Formerly included in EC 3.4.24.11
History
EC 3.4.24.18 created 1992
Orthology
K01395  meprin A
Genes
HSA: 4224(MEP1A)
PTR: 462745(MEP1A)
PPS: 100993933(MEP1A)
GGO: 101124221(MEP1A)
PON: 100456833(MEP1A)
NLE: 100602114(MEP1A) 105739117
MCC: 704781(MEP1A)
MCF: 102141031(MEP1A)
CSAB: 103221409(MEP1A)
RRO: 104656801(MEP1A)
RBB: 108512427(MEP1A)
CJC: 100385555(MEP1A)
SBQ: 101050703(MEP1A)
MMU: 17287(Mep1a)
RNO: 25684(Mep1a)
CGE: 100771501(Mep1a)
NGI: 103744884(Mep1a)
HGL: 101716131(Mep1a)
CCAN: 109698380(Mep1a)
OCU: 100348747(MEP1A)
TUP: 102476731(MEP1A)
CFA: 481826(MEP1A)
AML: 100467739(MEP1A)
UMR: 103664139(MEP1A)
ORO: 101380422(MEP1A)
FCA: 101101056(MEP1A)
PTG: 102969174(MEP1A)
AJU: 106973949(MEP1A)
BTA: 513936(MEP1A)
BOM: 102270268(MEP1A)
BIU: 109576819(MEP1A)
PHD: 102318619(MEP1A)
CHX: 102184856(MEP1A)
OAS: 101116774(MEP1A)
SSC: 100154136(MEP1A)
CFR: 102520791(MEP1A)
CDK: 105101209(MEP1A)
BACU: 103017419(MEP1A)
LVE: 103087996(MEP1A)
OOR: 101277573(MEP1A)
ECB: 100068383(MEP1A)
EPZ: 103566247(MEP1A)
EAI: 106828780(MEP1A)
MYB: 102251668(MEP1A)
MYD: 102754774(MEP1A)
HAI: 109396009(MEP1A)
RSS: 109448884(MEP1A)
PALE: 102894555(MEP1A)
LAV: 100657109(MEP1A)
TMU: 101348614
MDO: 100014629(MEP1A)
SHR: 100920569(MEP1A)
OAA: 100080933(MEP1A)
GGA: 422060(MEP1A)
MGP: 100550277(MEP1A)
CJO: 107312462(MEP1A)
APLA: 101798272(MEP1A) 101798463
TGU: 100223713(MEP1A)
GFR: 102034827(MEP1A)
FAB: 101810044(MEP1A)
PHI: 102112290(MEP1A)
PMAJ: 107201583(MEP1A)
CCAE: 111927425(MEP1A)
CCW: 104685391(MEP1A)
FPG: 101917590 101917757(MEP1A)
FCH: 102054284 102054455(MEP1A)
CLV: 102093522(MEP1A)
AAM: 106495190 106495197(MEP1A)
ASN: 102387802 102388049(MEP1A)
AMJ: 102561580(MEP1A) 102561804
PSS: 102462010(MEP1A)
CMY: 102929325(MEP1A)
CPIC: 101931408(MEP1A)
PBI: 103066442
XLA: 100037179(mep1a.L) 447263
XTR: 548484(mep1a)
NPR: 108796542(MEP1A)
DRE: 565535(mep1a.2)
CCAR: 109067933
MZE: 101473763
LCM: 102347949 102363508(MEP1A)
 » show all
Taxonomy
Reference
1  [PMID:7041888]
  Authors
Beynon RJ, Shannon JD, Bond JS.
  Title
Purification and characterization of a metallo-endoproteinase from mouse kidney.
  Journal
Biochem J 199:591-8 (1981)
Reference
2  [PMID:3105525]
  Authors
Butler PE, McKay MJ, Bond JS.
  Title
Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney.
  Journal
Biochem J 241:229-35 (1987)
Reference
3  [PMID:2461706]
  Authors
Stephenson SL, Kenny AJ.
  Title
The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2' and by rat microvillar membranes.
  Journal
Biochem J 255:45-51 (1988)
Reference
4  [PMID:3261961]
  Authors
Sterchi EE, Naim HY, Lentze MJ, Hauri HP, Fransen JA.
  Title
N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: a metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides.
  Journal
Arch Biochem Biophys 265:105-18 (1988)
DOI:10.1016/0003-9861(88)90376-1
Reference
5  [PMID:2690825]
  Authors
Barnes K, Ingram J, Kenny AJ.
  Title
Proteins of the kidney microvillar membrane. Structural and immunochemical properties of rat endopeptidase-2 and its immunohistochemical localization in tissues of rat and mouse.
  Journal
Biochem J 264:335-46 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.18
IUBMB Enzyme Nomenclature: 3.4.24.18
ExPASy - ENZYME nomenclature database: 3.4.24.18
BRENDA, the Enzyme Database: 3.4.24.18
CAS: 148938-24-3

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