KEGG   ENZYME: 3.4.24.23Help
Entry
EC 3.4.24.23                Enzyme                                 

Name
matrilysin;
matrin;
uterine metalloendopeptidase;
matrix metalloproteinase 7;
putative (or punctuated) metalloproteinase-1;
matrix metalloproteinase pump 1;
MMP 7;
PUMP-1 proteinase;
PUMP;
metalloproteinase pump-1;
putative metalloproteinase;
MMP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Ala14!Leu and Tyr16!Leu in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha2(I) > alpha1(I)
Comment
Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll
History
EC 3.4.24.23 created 1992
Orthology
K01397  matrix metalloproteinase-7 (matrilysin, uterine)
Genes
HSA: 4316(MMP7)
PTR: 451509(MMP7)
PPS: 100969359(MMP7)
GGO: 101129238(MMP7) 109025397
PON: 100458458(MMP7)
NLE: 100581294(MMP7)
MCC: 703072(MMP7)
MCF: 102139796(MMP7)
CSAB: 103248342(MMP7)
RRO: 104674660(MMP7)
RBB: 108514063(MMP7)
CJC: 100394775(MMP7)
SBQ: 101053487(MMP7)
MMU: 17393(Mmp7)
RNO: 25335(Mmp7)
CGE: 100760540(Mmp7)
NGI: 103731642(Mmp7)
HGL: 101718114(Mmp7)
CCAN: 109689246(Mmp7)
OCU: 100357971(MMP7)
TUP: 102492968(MMP7)
CFA: 489432(MMP7)
AML: 100480431(MMP7)
UMR: 103662460(MMP7)
ORO: 101373992(MMP7)
FCA: 727698(MMP7)
PTG: 102971750(MMP7)
AJU: 106976492(MMP7)
BTA: 286794(MMP7)
BOM: 102286488(MMP7)
BIU: 109569205(MMP7)
PHD: 102340229(MMP7)
CHX: 102173210(MMP7)
OAS: 100192317(MMP7)
SSC: 397411(MMP7)
CFR: 102514476(MMP7)
CDK: 105087173(MMP7)
BACU: 103008313(MMP7)
LVE: 103091433(MMP7)
OOR: 101277151(MMP7)
ECB: 100068985(MMP7)
EPZ: 103552631(MMP7)
EAI: 106843114(MMP7)
MYB: 102242272(MMP7)
MYD: 102771393(MMP7)
RSS: 109435093(MMP7)
PALE: 102884900(MMP7)
LAV: 100655566(MMP7)
TMU: 101346853
MDO: 100012296(MMP7)
SHR: 100933647(MMP7)
OAA: 100079035(MMP7)
GGA: 418983(MMP7)
MGP: 100543554(MMP7)
CJO: 107308406
APLA: 101793749(MMP7)
ACYG: 106034123(MMP7)
TGU: 100231056(MMP7)
FAB: 101821768(MMP7)
PHI: 102109334(MMP7)
PMAJ: 107206059(MMP7)
CCAE: 111923545(MMP7)
CCW: 104690112(MMP7)
FPG: 101913643(MMP10)
FCH: 102052975
CLV: 102097689(MMP7)
EGZ: 104128913(MMP7)
AAM: 106495507
ASN: 102388711(MMP7)
AMJ: 102564382(MMP7)
CMY: 102941027
CPIC: 101948697(MMP7)
ACS: 100553635(mmp7) 100553835
PVT: 110089076
VAR: 108318821
CMAX: 111485012
CPEP: 111780721
CCAV: 112515730
 » show all
Taxonomy
Reference
1  [PMID:2844164]
  Authors
Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R.
  Title
The collagenase gene family in humans consists of at least four members.
  Journal
Biochem J 253:187-92 (1988)
  Sequence
[hsa:4319]
Reference
2  [PMID:3182822]
  Authors
Woessner JF Jr, Taplin CJ.
  Title
Purification and properties of a small latent matrix metalloproteinase of the rat uterus.
  Journal
J Biol Chem 263:16918-25 (1988)
Reference
3  [PMID:2550050]
  Authors
Quantin B, Murphy G, Breathnach R.
  Title
Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members.
  Journal
Biochemistry 28:5327-34 (1989)
  Sequence
[hsa:4316]
Reference
4  [PMID:2253219]
  Authors
Miyazaki K, Hattori Y, Umenishi F, Yasumitsu H, Umeda M.
  Title
Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.
  Journal
Cancer Res 50:7758-64 (1990)
  Sequence
[hsa:4316]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.23
IUBMB Enzyme Nomenclature: 3.4.24.23
ExPASy - ENZYME nomenclature database: 3.4.24.23
BRENDA, the Enzyme Database: 3.4.24.23
CAS: 141256-52-2

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