KEGG ENZYME: 3.4.24.29

ENZYME: 3.4.24.29

Entry

EC 3.4.24.29 Enzyme

Name

aureolysin;
Staphylococcus aureus neutral proteinase;
Staphylococcus aureus neutral protease

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus

Comment

A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymic activator of plasminogen).

History

EC 3.4.24.29 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.29

Orthology

K01401

aureolysin

Genes

SAU:	SA2430(aur)

SAV:	SAV2637(aur)

SAW:	SAHV_2621(aur)

SAH:	SaurJH1_2717

SAJ:	SaurJH9_2661

SAM:	MW2558(aur)

SAS:

SAS2523

SAR:	SAR2716(aur)

SAC:	SACOL2659(aur)

SAX:	USA300HOU_2637(aur)

SAA:	SAUSA300_2572(aur)

SAO:	SAOUHSC_02971

SAE:	NWMN_2536(aur)

SAD:	SAAV_2706(aur)

SUU:	M013TW_2618

SUV:	SAVC_12065

SUE:	SAOV_2686c

SUJ:	SAA6159_02533(aur)

SUK:	SAA6008_02696(aur)

SUC:	ECTR2_2491

SUT:	SAT0131_02903

SUQ:	HMPREF0772_10550(aur)

SUZ:	MS7_2642(aur)

SUD:	ST398NM01_2687

SUX:	SAEMRSA15_25420(aur)

SUW:	SATW20_27750(aur)

SUG:

SAPIG2687

SUF:	SARLGA251_24090(aur)

SAUA:

SAAG_00459

SAUE:

RSAU_002480(aur)

SAUN:

SAKOR_02638

SAUS:

SA40_2393(aur)

SAUU:

SA957_2477(aur)

SAUG:

SA268_2574(aur)

SAUZ:

SAZ172_2756(aur)

SAUT:

SAI1T1_2019740(aur)

SAUJ:

SAI2T2_1019750(aur)

SAUK:

SAI3T3_1019740(aur)

SAUQ:

SAI4T8_1019750(aur)

SAUV:

SAI7S6_1019740(aur)

SAUW:

SAI5S5_1019680(aur)

SAUX:

SAI6T6_1019690(aur)

SAUY:

SAI8T7_1019720(aur)

SAUF:

X998_2620

SAB:	SAB2512c(aur)

SUY:	SA2981_2576(aur)

SAUB:

C248_2705(aur)

SAUM:

BN843_26750

SAUC:

CA347_2714 CA347_2715

SAUR:

SABB_04255(aur)

SAUI:

AZ30_13795

SAUD:

CH52_05820

SAMS:

NI36_13265

SUH:	SAMSHR1132_24610

SEP:

SE2219

SER:	SERP2252(sepA)

SEPP:

SEB_02220

SEPS:

DP17_1151(sepA)

SSP:

SSP1542

SSD:	SPSINT_2146

SDT:

SPSE_0326

SWA:	A284_01205

SPAS:

STP1_1156

SXY:	BE24_03405

SXL:	SXYLSMQ121_1581

SXO:	SXYL_01658

SHU:	SHYC_09855(aur)

SCAP:

AYP1020_1844(sepA)

SSCH:

SSCZ:

SAGQ:

SEQO:

SLZ:	B5P37_04350

SCOH:

BZ166_12190

SSCU:

CEP64_01805

SNL:	BJD96_08540

SKL:	C7J89_09685

SFQ:	C7J90_00795

MCL:

MCCL_1675

MCAK:

MCCS_05170(sepA_2) MCCS_23430(sepA_3)

MACR:

BHM04_00285

PSOR:

RSJ16_08260

» show all

Reference

1 [PMID:4632563]

Authors

Arvidson S.

Title

Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease.

Journal

Biochim Biophys Acta 302:149-57 (1973)
DOI:10.1016/0005-2744(73)90017-X

Reference

2 [PMID:823980]

Authors

Saheb SA.

Title

[Purification and characterization of an extracellular protease from Staphylococcus aureus inhibited by EDTA]

Journal

Biochimie 58:793-804 (1976)
DOI:10.1016/S0300-9084(76)80310-0

Reference

3 [PMID:711676]

Authors

Drapeau GR.

Title

Role of metalloprotease in activation of the precursor of staphylococcal protease.

Journal

J Bacteriol 136:607-13 (1978)

Reference

4 [PMID:2512988]

Authors

Potempa J, Porwit-Bobr Z, Travis J.

Title

Stabilization vs. degradation of Staphylococcus aureus metalloproteinase.

Journal

Biochim Biophys Acta 993:301-4 (1989)
DOI:10.1016/0304-4165(89)90181-5

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.29

IUBMB Enzyme Nomenclature:

3.4.24.29

ExPASy - ENZYME nomenclature database:

3.4.24.29

BRENDA, the Enzyme Database:

3.4.24.29

CAS:	39335-13-2

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Gene (86)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (84)   
   EGENES (1)   
Protein sequence (110)   
   UniProt (59)   
   SWISS-PROT (1)   
   RefSeq(pep) (43)   
   PDBSTR (7)   
DNA sequence (3904)   
   RefSeq(nuc) (3634)   
   GenBank (135)   
   EMBL (135)   
3D Structure (4)   
   PDB (4)   
All databases (4104)   

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