KEGG   ENZYME: 3.4.24.29
Entry
EC 3.4.24.29                Enzyme                                 

Name
aureolysin;
Staphylococcus aureus neutral proteinase;
Staphylococcus aureus neutral protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus
Comment
A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymic activator of plasminogen).
History
EC 3.4.24.29 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.29
Orthology
K01401  aureolysin
Genes
SDO: SD1155_03045
SAU: SA2430(aur)
SAV: SAV2637(aur)
SAW: SAHV_2621(aur)
SAH: SaurJH1_2717
SAJ: SaurJH9_2661
SAM: MW2558(aur)
SAS: SAS2523
SAR: SAR2716(aur)
SAC: SACOL2659(aur)
SAX: USA300HOU_2637(aur)
SAA: SAUSA300_2572(aur)
SAO: SAOUHSC_02971
SAE: NWMN_2536(aur)
SAD: SAAV_2706(aur)
SUU: M013TW_2618(aur)
SUV: SAVC_12065
SUE: SAOV_2686c
SUJ: SAA6159_02533(aur)
SUK: SAA6008_02696(aur)
SUC: ECTR2_2491
SUT: SAT0131_02903
SUQ: HMPREF0772_10550(aur)
SUZ: MS7_2642(aur)
SUD: ST398NM01_2687
SUX: SAEMRSA15_25420(aur)
SUW: SATW20_27750(aur)
SUG: SAPIG2687
SUF: SARLGA251_24090(aur)
SAUA: SAAG_00459
SAUE: RSAU_002480(aur)
SAUN: SAKOR_02638
SAUS: SA40_2393(aur)
SAUU: SA957_2477(aur)
SAUG: SA268_2574(aur)
SAUZ: SAZ172_2756(aur)
SAUT: SAI1T1_2019740(aur)
SAUJ: SAI2T2_1019750(aur)
SAUK: SAI3T3_1019740(aur)
SAUQ: SAI4T8_1019750(aur)
SAUV: SAI7S6_1019740(aur)
SAUW: SAI5S5_1019680(aur)
SAUX: SAI6T6_1019690(aur)
SAUY: SAI8T7_1019720(aur)
SAUF: X998_2620
SAB: SAB2512c(aur)
SUY: SA2981_2576(aur)
SAUB: C248_2705(aur)
SAUM: BN843_26750
SAUC: CA347_2715
SAUR: SABB_04255(aur)
SAUI: AZ30_13795
SAUD: CH52_05820
SAMS: NI36_13265
SUH: SAMSHR1132_24610
SER: SERP2252(sepA)
SEP: SE2219
SEPP: SEB_02220
SEPS: DP17_1151(sepA)
SSP: SSP1542
SSD: SPSINT_2146
SDT: SPSE_0326
SDP: NCTC12225_00398(aur)
SWA: A284_01205
SPAS: STP1_1156
SXY: BE24_03405
SXL: SXYLSMQ121_1581
SXO: SXYL_01658
SHU: SHYC_09855(aur)
SCAP: AYP1020_1844(sepA)
SSCH: LH95_01925
SSCZ: RN70_02240
SAGQ: EP23_00125
SEQO: SE1039_10430
SLZ: B5P37_04350
SCOH: BZ166_12190
SNL: BJD96_08540
SKL: C7J89_09685
SFQ: C7J90_00795
SCAR: DWB96_01280
SCHR: DWB92_10010
SARL: SAP2_16170
SSH: NCTC13712_02592(aur)
SSIM: SAMEA4384339_2444(aur)
SSCU: CEP64_01805
SFF: FOB90_05845
SSTE: SAMEA4384403_0437(sepA_2)
MCL: MCCL_1675
MCAK: MCCS_05170(sepA_2) MCCS_23430(sepA_3)
MACR: BHM04_00285
PSOR: RSJ16_08260
 » show all
Reference
1  [PMID:4632563]
  Authors
Arvidson S.
  Title
Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease.
  Journal
Biochim Biophys Acta 302:149-57 (1973)
DOI:10.1016/0005-2744(73)90017-X
Reference
2  [PMID:823980]
  Authors
Saheb SA.
  Title
[Purification and characterization of an extracellular protease from Staphylococcus aureus inhibited by EDTA]
  Journal
Biochimie 58:793-804 (1976)
DOI:10.1016/S0300-9084(76)80310-0
Reference
3  [PMID:711676]
  Authors
Drapeau GR.
  Title
Role of metalloprotease in activation of the precursor of staphylococcal protease.
  Journal
J Bacteriol 136:607-13 (1978)
DOI:10.1128/JB.136.2.607-613.1978
Reference
4  [PMID:2512988]
  Authors
Potempa J, Porwit-Bobr Z, Travis J.
  Title
Stabilization vs. degradation of Staphylococcus aureus metalloproteinase.
  Journal
Biochim Biophys Acta 993:301-4 (1989)
DOI:10.1016/0304-4165(89)90181-5
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.29
IUBMB Enzyme Nomenclature: 3.4.24.29
ExPASy - ENZYME nomenclature database: 3.4.24.29
BRENDA, the Enzyme Database: 3.4.24.29
CAS: 39335-13-2

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Gene (93)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (92)   
Protein sequence (386)   
   UniProt (28)   
   SWISS-PROT (1)   
   RefSeq(pep) (350)   
   PDBSTR (7)   
DNA sequence (13117)   
   RefSeq(nuc) (12293)   
   GenBank (526)   
   EMBL (298)   
3D Structure (4)   
   PDB (4)   
Protein domain (6)   
   InterPro (6)   
All databases (13606)   

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