Entry |
|
Name |
aureolysin;
Staphylococcus aureus neutral proteinase;
Staphylococcus aureus neutral protease
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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Reaction(IUBMB) |
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus
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Comment |
A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymic activator of plasminogen).
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History |
EC 3.4.24.29 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.29
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Arvidson S. |
Title |
Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease. |
Journal |
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Reference |
|
Authors |
Saheb SA. |
Title |
[Purification and characterization of an extracellular protease from Staphylococcus aureus inhibited by EDTA] |
Journal |
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Reference |
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Authors |
Drapeau GR. |
Title |
Role of metalloprotease in activation of the precursor of staphylococcal protease. |
Journal |
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Reference |
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Authors |
Potempa J, Porwit-Bobr Z, Travis J. |
Title |
Stabilization vs. degradation of Staphylococcus aureus metalloproteinase. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.24.29 |
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