KEGG   ENZYME: 3.4.24.36Help
Entry
EC 3.4.24.36                Enzyme                                 

Name
leishmanolysin;
promastigote surface endopeptidase;
glycoprotein gp63;
Leishmania metalloproteinase;
surface acid proteinase;
promastigote surface protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr!Leu-Lys-Lys-
Comment
A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans. Contains consensus sequence for a zinc-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The enzyme can activate its proenzyme by cleavage of the Val100!Val bond. An acid pH optimum is found with certain protein substrates. Type example of peptidase family M8
History
EC 3.4.24.36 created 1992
Orthology
K01404  leishmanolysin
Genes
ATH: AT5G42620
ALY: ARALYDRAFT_494774
CRB: 17875516
CSAT: 104725219 104760706 104771388
EUS: EUTSA_v10022547mg
BRP: 103828018
BNA: 106349526 111198782
BOE: 106342481
THJ: 104806880 104809128
CPAP: 110813552
CIT: 102621178
TCC: 18591336
EGR: 104416623
LJA: Lj5g3v0085120.1(Lj5g3v0085120.1) Lj5g3v0085120.2(Lj5g3v0085120.2) Lj5g3v2297750.1(Lj5g3v2297750.1) Lj5g3v2297750.2(Lj5g3v2297750.2)
ADU: 107495963
AIP: 107605731
FVE: 101308254
PPER: 18791128
PMUM: 103320808
PAVI: 110762610
ZJU: 107420265
CSV: 101217702
CMO: 103487946
MCHA: 111013969
RCU: 8260940
JCU: 105633745
VVI: 100257368
SLY: 101248771
SPEN: 107017811
SOT: 102596537
CANN: 107867059
NSY: 104212740
NTO: 104091581
INI: 109170300
BVG: 104898653
SOE: 110785245
NNU: 104595772
OSA: 4334001
DOSA: Os03t0731500-01(Os03g0731500)
OBR: 102704227
BDI: 100831389
ATS: 109780249
SBI: 8059951
ZMA: 103643963
SITA: 101779712
PDA: 103707501
EGU: 105055836
DCT: 110100801
PEQ: 110031986
AOF: 109822512
ATR: 18445929
DFA: DFA_06007(sigB)
EHI: EHI_042870(111.t00003) EHI_200230(30.t00006)
SPAR: SPRG_12195
 » show all
Taxonomy
Reference
1  [PMID:3346625]
  Authors
Button LL, McMaster WR.
  Title
Molecular cloning of the major surface antigen of leishmania.
  Journal
J Exp Med 167:724-9 (1988)
  Sequence
Reference
2  [PMID:2608099]
  Authors
Bouvier J, Bordier C, Vogel H, Reichelt R, Etges R.
  Title
Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase.
  Journal
Mol Biochem Parasitol 37:235-45 (1989)
DOI:10.1016/0166-6851(89)90155-2
Reference
3  [PMID:2708373]
  Authors
Chaudhuri G, Chaudhuri M, Pan A, Chang KP.
  Title
Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages.
  Journal
J Biol Chem 264:7483-9 (1989)
Reference
4  [PMID:2271643]
  Authors
Bouvier J, Schneider P, Etges R, Bordier C.
  Title
Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania.
  Journal
Biochemistry 29:10113-9 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.36
IUBMB Enzyme Nomenclature: 3.4.24.36
ExPASy - ENZYME nomenclature database: 3.4.24.36
BRENDA, the Enzyme Database: 3.4.24.36
CAS: 161052-06-8

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