Entry |
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Name |
atrolysin C;
Crotalus atrox metalloendopeptidase c;
hemorrhagic toxin c and d
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Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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Reaction(IUBMB) |
Cleavage of His5!Leu, His10!Leu, Ala14!Leu, Tyr16!Leu and Gly23!Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1
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Comment |
A 24 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests type IV collagen, and exists as two forms, c and d. Phosphoramidon inhibits in the 0.1 mM range. In peptidase family M12 (astacin family). Hemorrhagic toxin-2 of C. ruber ruber has the same Mr and specificity and is a homologue [4,6].
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History |
EC 3.4.24.42 created 1992
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Orthology |
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Reference |
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Authors |
Bjarnason JB, Tu AT. |
Title |
Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e. |
Journal |
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Reference |
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Authors |
Fox JW, Campbell R, Beggerly L, Bjarnason JB. |
Title |
Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom. |
Journal |
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Reference |
|
Authors |
Bjarnason JB, Fox JW. |
Title |
Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom. |
Journal |
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Reference |
|
Authors |
Mori N, Nikai T, Sugihara H, Tu AT. |
Title |
Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom. |
Journal |
|
Reference |
|
Authors |
Shannon JD, Baramova EN, Bjarnason JB, Fox JW |
Title |
Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin. |
Journal |
J Biol Chem 264:11575-83 (1989) |
Sequence |
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Reference |
|
Authors |
Takeya H, Onikura A, Nikai T, Sugihara H, Iwanaga S. |
Title |
Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.24.42 |
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