KEGG   ENZYME: 3.4.24.48Help
Entry
EC 3.4.24.48                Enzyme                                 

Name
ruberlysin;
Crotalus ruber metalloendopeptidase II;
hemorrhagic toxin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of His10!Leu, Ala14!Leu, Tyr16!Leu and Gly23!Phe bonds in the B chain of insulin; His!Pro, Pro!Phe, and Trp!Ser of angiotensin I; and Gly!Phe of Met enkephalin
Comment
A 25 kDa hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen. In peptidase family M12 (astacin family)
History
EC 3.4.24.48 created 1992
Reference
1  [PMID:2949699]
  Authors
Mori N, Nikai T, Sugihara H, Tu AT.
  Title
Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom.
  Journal
Arch Biochem Biophys 253:108-21 (1987)
DOI:10.1016/0003-9861(87)90643-6
Reference
2  [PMID:2081731]
  Authors
Takeya H, Onikura A, Nikai T, Sugihara H, Iwanaga S.
  Title
Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber.
  Journal
J Biochem (Tokyo) 108:711-9 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.48
IUBMB Enzyme Nomenclature: 3.4.24.48
ExPASy - ENZYME nomenclature database: 3.4.24.48
BRENDA, the Enzyme Database: 3.4.24.48
CAS: 846020-01-7

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