KEGG   ENZYME: 3.4.24.6Help
Entry
EC 3.4.24.6                 Enzyme                                 

Name
leucolysin;
Leucostoma neutral proteinase;
Leucostoma peptidase A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of Phe1!Val, His5!Leu, Ala14!Leu, Gly20!Glu, Gly23!Phe and Phe24!Phe bonds in insulin B chain as well as N-blocked dipeptides
Comment
From the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma).
History
EC 3.4.24.6 created 1978
Reference
1  [PMID:5684005]
  Authors
Wagner FW, Spiekerman AM, Prescott JM.
  Title
Leucostoma peptidase A. Isolation and physical properties.
  Journal
J Biol Chem 243:4486-93 (1968)
Reference
2  [PMID:4711816]
  Authors
Spiekerman AM, Fredericks KK, Wagner FW, Prescott JM.
  Title
Leucostoma peptidase A: a metalloprotease from snake venom.
  Journal
Biochim Biophys Acta 293:464-75 (1973)
DOI:10.1016/0005-2744(73)90353-7
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.6
IUBMB Enzyme Nomenclature: 3.4.24.6
ExPASy - ENZYME nomenclature database: 3.4.24.6
BRENDA, the Enzyme Database: 3.4.24.6
CAS: 72561-03-6

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